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World-2DPAGE Repository
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SWISS-2DPAGE
World-2DPAGE Portal
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Searching in 'World-2DPAGE Repository [0004]' for entry
matching:
MK01_RAT
World-2DPAGE Repository
(0004):
MK01_RAT
MK01_RAT
General information about the entry
View entry in simple text format
Entry name
MK01_RAT
Primary accession number
P63086
integrated into World-2DPAGE Repository (0004) on
October 13, 2008 (release 1)
2D Annotations were last modified on
May 18, 2011 (version 2)
General Annotations were last modified on
December 22, 2011 (version 2)
Name and origin of the protein
Description
RecName: Full=Mitogen-activated protein kinase 1; Short=MAP kinase 1; Short=MAPK 1; EC=2.7.11.24; AltName: Full=ERT1; AltName: Full=Extracellular signal-regulated kinase 2; Short=ERK-2; AltName: Full=MAP kinase isoform p42; Short=p42-MAPK; AltName: Full=Mitogen-activated protein kinase 2; Short=MAP kinase 2; Short=MAPK 2;.
Gene name
Name=Mapk1
Synonyms=Erk2, Mapk, Prkm1
Annotated species
Rattus norvegicus (Rat) [TaxID:
10116
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
References
[1]
MAPPING ON GEL
PubMed=19343716; DOI=
10.1002/pmic.200800664
; [
NCBI
,
EBI
,
Israel
,
Japan
]
Maurya D.K., Sundaram C.S., Bhargava P.
''Proteome profile of the mature rat olfactory bulb''
Proteomics 9(1):2593-2599 (2009)
2D PAGE maps for identified proteins
How to interpret a protein
OB21DSUB
{2-DE gel for Olfactory bulb proteome}
Rattus norvegicus (Rat)
Tissue: Olfactory bulb
map experimental info
OB21DSUB
MAP LOCATIONS:
SPOT 450
:
pI=6.40; Mw=43000
[identification data]
MAPPING (identification):
SPOT
450
:
Peptide mass fingerprinting
[
1
];
Tandem mass spectrometry
[
1
].
Copyright
Data from Dr. Purnima Bhargava, Centre for Cellular and Molecular Biology, India
Cross-references
UniProtKB/Swiss-Prot
P63086; MK01_RAT.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
2011_12
Entry name
MK01_RAT
Primary accession number
P63086
Secondary accession number(s)
P27703
Sequence was last modified on
January 23, 2007 (version 3)
Annotations were last modified on
December 14, 2011 (version 96)
Name and origin of the protein
Description
RecName: Full=Mitogen-activated protein kinase 1; Short=MAP kinase 1; Short=MAPK 1; EC=2.7.11.24; AltName: Full=ERT1; AltName: Full=Extracellular signal-regulated kinase 2; Short=ERK-2; AltName: Full=MAP kinase isoform p42; Short=p42-MAPK; AltName: Full=Mitogen-activated protein kinase 2; Short=MAP kinase 2; Short=MAPK 2;
Gene name
Name=Mapk1
Synonyms=Erk2, Mapk, Prkm1
Encoded on
Name=Mapk1; Synonyms=Erk2, Mapk, Prkm1
Keywords
3D-structure
;
Acetylation
;
ATP-binding
;
Cell cycle
;
Complete proteome
;
Cytoplasm
;
Cytoskeleton
;
Direct protein sequencing
;
Kinase
;
Nucleotide-binding
;
Nucleus
;
Phosphoprotein
;
Reference proteome
;
Serine/threonine-protein kinase
;
Transferase
.
Copyright
Copyrighted by the UniProt Consortium, see
https://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
M64300; AAA41124.1
; -; mRNA
IPI
IPI00199688; -
; .
PIR
A40033; A40033
; .
RefSeq
NP_446294.1; NM_053842.1
; .
UniGene
Rn.34914; -
; .
PDB
1ERK; X-ray
; 2.30 A; A=1-358
PDB
1GOL; X-ray
; 2.80 A; A=1-358
PDB
2ERK; X-ray
; 2.40 A; A=1-358
PDB
2FYS; X-ray
; 2.50 A; A/B=2-357
PDB
2GPH; X-ray
; 1.90 A; A=2-357
PDB
2Z7L; X-ray
; 2.41 A; A=1-358
PDB
3C9W; X-ray
; 2.50 A; A/B=2-358
PDB
3ERK; X-ray
; 2.10 A; A=1-358
PDB
3O71; X-ray
; 1.95 A; A=1-358
PDB
3QYW; X-ray
; 1.50 A; A=1-358
PDB
3QYZ; X-ray
; 1.46 A; A=1-358
PDB
3R63; X-ray
; 1.70 A; A=1-358
PDB
4ERK; X-ray
; 2.20 A; A=1-358
PDBsum
1ERK; -
; .
PDBsum
1GOL; -
; .
PDBsum
2ERK; -
; .
PDBsum
2FYS; -
; .
PDBsum
2GPH; -
; .
PDBsum
2Z7L; -
; .
PDBsum
3C9W; -
; .
PDBsum
3ERK; -
; .
PDBsum
3O71; -
; .
PDBsum
3QYW; -
; .
PDBsum
3QYZ; -
; .
PDBsum
3R63; -
; .
PDBsum
4ERK; -
; .
ProteinModelPortal
P63086; -
; .
SMR
P63086; 6-355
; .
DIP
DIP-29117N; -
; .
IntAct
P63086; 2
; .
MINT
MINT-100037; -
; .
STRING
P63086; -
; .
PhosphoSite
P63086; -
; .
World-2DPAGE
0004:P63086; -
; .
PRIDE
P63086; -
; .
GeneID
116590; -
; .
KEGG
rno:116590; -
; .
CTD
5594; -
; .
RGD
70500; Mapk1
; .
eggNOG
roNOG04134; -
; .
GeneTree
ENSGT00550000074298; -
; .
HOVERGEN
HBG014652; -
; .
InParanoid
P63086; -
; .
OrthoDB
EOG45HRXM; -
; .
PhylomeDB
P63086; -
; .
BRENDA
2.7.11.24; 5301
; .
Reactome
REACT_109781; Immune System
; .
Reactome
REACT_111984; Signal Transduction
; .
Reactome
REACT_112697; Developmental Biology
; .
NextBio
619269; -
; .
ArrayExpress
P63086; -
; .
Genevestigator
P63086; -
; .
GermOnline
ENSRNOG00000001849; Rattus norvegicus
; .
GO
GO:0033267; C:axon part
; IDA:RGD; .
GO
GO:0005829; C:cytosol
; IDA:RGD; .
GO
GO:0032839; C:dendrite cytoplasm
; IDA:RGD; .
GO
GO:0005626; C:insoluble fraction
; IDA:RGD; .
GO
GO:0005815; C:microtubule organizing center
; IEA:UniProtKB-SubCell; .
GO
GO:0005654; C:nucleoplasm
; IDA:UniProtKB; .
GO
GO:0043204; C:perikaryon
; IDA:RGD; .
GO
GO:0043234; C:protein complex
; IDA:RGD; .
GO
GO:0005625; C:soluble fraction
; IDA:RGD; .
GO
GO:0005524; F:ATP binding
; IDA:RGD; .
GO
GO:0004707; F:MAP kinase activity
; IDA:UniProtKB; .
GO
GO:0031435; F:mitogen-activated protein kinase kinase kinase binding
; IPI:RGD; .
GO
GO:0008134; F:transcription factor binding
; IPI:RGD; .
GO
GO:0007049; P:cell cycle
; IEA:UniProtKB-KW; .
GO
GO:0000189; P:MAPK import into nucleus
; IDA:RGD; .
GO
GO:0030335; P:positive regulation of cell migration
; IEP:RGD; .
GO
GO:0008284; P:positive regulation of cell proliferation
; IEP:RGD; .
GO
GO:0045893; P:positive regulation of transcription
; DNA-dependent; IEP:RGD
GO
GO:0045727; P:positive regulation of translation
; IMP:RGD; .
GO
GO:0043627; P:response to estrogen stimulus
; IDA:RGD; .
GO
GO:0009636; P:response to toxin
; IDA:RGD; .
GO
GO:0019233; P:sensory perception of pain
; IMP:UniProtKB; .
InterPro
IPR008349; Erk_1_2_MAPK
; .
InterPro
IPR011009; Kinase-like_dom
; .
InterPro
IPR003527; MAP_kinase_CS
; .
InterPro
IPR000719; Prot_kinase_cat_dom
; .
InterPro
IPR017441; Protein_kinase_ATP_BS
; .
InterPro
IPR017442; Se/Thr_kinase-like_dom
; .
InterPro
IPR008271; Ser/Thr_kinase_AS
; .
InterPro
IPR002290; Ser/Thr_kinase_dom
; .
KO
K04371; -
; .
Pfam
PF00069; Pkinase
; 1; .
PRINTS
PR01770; ERK1ERK2MAPK
; .
SMART
SM00220; S_TKc
; 1; .
SUPFAM
SSF56112; Kinase_like
; 1; .
PROSITE
PS01351; MAPK
; 1; .
PROSITE
PS00107; PROTEIN_KINASE_ATP
; 1; .
PROSITE
PS50011; PROTEIN_KINASE_DOM
; 1; .
PROSITE
PS00108; PROTEIN_KINASE_ST
; 1; .
World-2DPAGE Repository (search AC)
Database constructed and maintained by
SIB
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
Expasy web server