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Searching in 'World-2DPAGE Repository [0004]' for entry matching: MK01_RAT




World-2DPAGE Repository (0004):  MK01_RAT

MK01_RAT


General information about the entry
View entry in simple text format
Entry nameMK01_RAT
Primary accession numberP63086
integrated into World-2DPAGE Repository (0004) on October 13, 2008 (release 1)
2D Annotations were last modified onMay 18, 2011 (version 2)
General Annotations were last modified on December 22, 2011 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Mitogen-activated protein kinase 1; Short=MAP kinase 1; Short=MAPK 1; EC=2.7.11.24; AltName: Full=ERT1; AltName: Full=Extracellular signal-regulated kinase 2; Short=ERK-2; AltName: Full=MAP kinase isoform p42; Short=p42-MAPK; AltName: Full=Mitogen-activated protein kinase 2; Short=MAP kinase 2; Short=MAPK 2;.
Gene nameName=Mapk1
Synonyms=Erk2, Mapk, Prkm1
Annotated speciesRattus norvegicus (Rat) [TaxID: 10116]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
References
[1]   MAPPING ON GEL
PubMed=19343716; DOI=10.1002/pmic.200800664; [NCBI, EBI, Israel, Japan]
Maurya D.K., Sundaram C.S., Bhargava P.
''Proteome profile of the mature rat olfactory bulb''
Proteomics 9(1):2593-2599 (2009)
2D PAGE maps for identified proteins
How to interpret a protein

OB21DSUB {2-DE gel for Olfactory bulb proteome}
Rattus norvegicus (Rat)
Tissue: Olfactory bulb
OB21DSUB
  map experimental info 		 
OB21DSUB

MAP LOCATIONS:
pI=6.40; Mw=43000  [identification data]

MAPPING (identification):
SPOT 450: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Copyright
Data from Dr. Purnima Bhargava, Centre for Cellular and Molecular Biology, India
Cross-references
UniProtKB/Swiss-ProtP63086; MK01_RAT.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_12
Entry nameMK01_RAT
Primary accession numberP63086
Secondary accession number(s) P27703
Sequence was last modified on January 23, 2007 (version 3)
Annotations were last modified on December 14, 2011 (version 96)
Name and origin of the protein
DescriptionRecName: Full=Mitogen-activated protein kinase 1; Short=MAP kinase 1; Short=MAPK 1; EC=2.7.11.24; AltName: Full=ERT1; AltName: Full=Extracellular signal-regulated kinase 2; Short=ERK-2; AltName: Full=MAP kinase isoform p42; Short=p42-MAPK; AltName: Full=Mitogen-activated protein kinase 2; Short=MAP kinase 2; Short=MAPK 2;
Gene nameName=Mapk1
Synonyms=Erk2, Mapk, Prkm1
Encoded onName=Mapk1; Synonyms=Erk2, Mapk, Prkm1
Keywords3D-structure; Acetylation; ATP-binding; Cell cycle; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM64300; AAA41124.1; -; mRNA
IPIIPI00199688; -; .
PIRA40033; A40033; .
RefSeqNP_446294.1; NM_053842.1; .
UniGeneRn.34914; -; .
PDB1ERK; X-ray; 2.30 A; A=1-358
PDB1GOL; X-ray; 2.80 A; A=1-358
PDB2ERK; X-ray; 2.40 A; A=1-358
PDB2FYS; X-ray; 2.50 A; A/B=2-357
PDB2GPH; X-ray; 1.90 A; A=2-357
PDB2Z7L; X-ray; 2.41 A; A=1-358
PDB3C9W; X-ray; 2.50 A; A/B=2-358
PDB3ERK; X-ray; 2.10 A; A=1-358
PDB3O71; X-ray; 1.95 A; A=1-358
PDB3QYW; X-ray; 1.50 A; A=1-358
PDB3QYZ; X-ray; 1.46 A; A=1-358
PDB3R63; X-ray; 1.70 A; A=1-358
PDB4ERK; X-ray; 2.20 A; A=1-358
PDBsum1ERK; -; .
PDBsum1GOL; -; .
PDBsum2ERK; -; .
PDBsum2FYS; -; .
PDBsum2GPH; -; .
PDBsum2Z7L; -; .
PDBsum3C9W; -; .
PDBsum3ERK; -; .
PDBsum3O71; -; .
PDBsum3QYW; -; .
PDBsum3QYZ; -; .
PDBsum3R63; -; .
PDBsum4ERK; -; .
ProteinModelPortalP63086; -; .
SMRP63086; 6-355; .
DIPDIP-29117N; -; .
IntActP63086; 2; .
MINTMINT-100037; -; .
STRINGP63086; -; .
PhosphoSiteP63086; -; .
World-2DPAGE0004:P63086; -; .
PRIDEP63086; -; .
GeneID116590; -; .
KEGGrno:116590; -; .
CTD5594; -; .
RGD70500; Mapk1; .
eggNOGroNOG04134; -; .
GeneTreeENSGT00550000074298; -; .
HOVERGENHBG014652; -; .
InParanoidP63086; -; .
OrthoDBEOG45HRXM; -; .
PhylomeDBP63086; -; .
BRENDA2.7.11.24; 5301; .
ReactomeREACT_109781; Immune System; .
ReactomeREACT_111984; Signal Transduction; .
ReactomeREACT_112697; Developmental Biology; .
NextBio619269; -; .
ArrayExpressP63086; -; .
GenevestigatorP63086; -; .
GermOnlineENSRNOG00000001849; Rattus norvegicus; .
GOGO:0033267; C:axon part; IDA:RGD; .
GOGO:0005829; C:cytosol; IDA:RGD; .
GOGO:0032839; C:dendrite cytoplasm; IDA:RGD; .
GOGO:0005626; C:insoluble fraction; IDA:RGD; .
GOGO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell; .
GOGO:0005654; C:nucleoplasm; IDA:UniProtKB; .
GOGO:0043204; C:perikaryon; IDA:RGD; .
GOGO:0043234; C:protein complex; IDA:RGD; .
GOGO:0005625; C:soluble fraction; IDA:RGD; .
GOGO:0005524; F:ATP binding; IDA:RGD; .
GOGO:0004707; F:MAP kinase activity; IDA:UniProtKB; .
GOGO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IPI:RGD; .
GOGO:0008134; F:transcription factor binding; IPI:RGD; .
GOGO:0007049; P:cell cycle; IEA:UniProtKB-KW; .
GOGO:0000189; P:MAPK import into nucleus; IDA:RGD; .
GOGO:0030335; P:positive regulation of cell migration; IEP:RGD; .
GOGO:0008284; P:positive regulation of cell proliferation; IEP:RGD; .
GOGO:0045893; P:positive regulation of transcription; DNA-dependent; IEP:RGD
GOGO:0045727; P:positive regulation of translation; IMP:RGD; .
GOGO:0043627; P:response to estrogen stimulus; IDA:RGD; .
GOGO:0009636; P:response to toxin; IDA:RGD; .
GOGO:0019233; P:sensory perception of pain; IMP:UniProtKB; .
InterProIPR008349; Erk_1_2_MAPK; .
InterProIPR011009; Kinase-like_dom; .
InterProIPR003527; MAP_kinase_CS; .
InterProIPR000719; Prot_kinase_cat_dom; .
InterProIPR017441; Protein_kinase_ATP_BS; .
InterProIPR017442; Se/Thr_kinase-like_dom; .
InterProIPR008271; Ser/Thr_kinase_AS; .
InterProIPR002290; Ser/Thr_kinase_dom; .
KOK04371; -; .
PfamPF00069; Pkinase; 1; .
PRINTSPR01770; ERK1ERK2MAPK; .
SMARTSM00220; S_TKc; 1; .
SUPFAMSSF56112; Kinase_like; 1; .
PROSITEPS01351; MAPK; 1; .
PROSITEPS00107; PROTEIN_KINASE_ATP; 1; .
PROSITEPS50011; PROTEIN_KINASE_DOM; 1; .
PROSITEPS00108; PROTEIN_KINASE_ST; 1; .


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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server