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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0019]' for entry matching: MP2K1_RAT World-2DPAGE Repository (0019):  MP2K1_RAT MP2K1_RAT General information about the entry View entry in simple text format Entry name MP2K1_RAT Primary accession number Q01986 integrated into World-2DPAGE Repository (0019) on  December 9, 2009 (release 1) 2D Annotations were last modified on May 30, 2011 (version 2) General Annotations were last modified on  January 13, 2012 (version 2) Name and origin of the protein Description RecName: Full=Dual specificity mitogen-activated protein kinase kinase 1; Short=MAP kinase kinase 1; Short=MAPKK 1; EC=2.7.12.2; AltName: Full=ERK activator kinase 1; AltName: Full=MAPK/ERK kinase 1; Short=MEK 1;. Gene name Name=Map2k1 Synonyms=Mek1, Prkmk1 Annotated species Rattus norvegicus (Rat) [TaxID: 10116] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus. References [1]   2D-PAGE GEL CHARACTERIZATION DOI=10.1111/j.1471-4159.2010.06719.x; VanGuilder H.D., Yan H., Farley J.A., Sonntag W.E., Freeman W.M. ''Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome'' J of Neurochemistry 113(6):1577-1588 (2010) 2D PAGE maps for identified proteins How to interpret a protein HIPP_SYNAP {Rat hippocampal synaptoproteome} Rattus norvegicus (Rat) Tissue: Hippocampus   map experimental info   HIPP_SYNAP MAP LOCATIONS: SPOT 540: pI=6.18; Mw=43779   [identification data] SPOT 541: pI=6.18; Mw=43779   [identification data] SPOT 543: pI=6.18; Mw=43779   [identification data] SPOT 1177: pI=6.18; Mw=43779   [identification data] IDENTIFICATION: SPOT 540: Peptides number=4. SeqCov=9.4%. MOWSE score=1.95E+2 [1] SPOT 541: Peptides number=2. SeqCov=6.4%. MOWSE score=1.95E+2 [1]; SPOT 543: Peptides number=3. SeqCov=9.4%. MOWSE score=7.89E+1 [1]; SPOT 1177: Peptides number=4. SeqCov=6.4%. MOWSE score=4.62E+2 [1]. MAPPING (identification): SPOT 540: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]; SPOT 541: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]; SPOT 543: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]; SPOT 1177: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Willard Freeman, Penn State College of Medicine, USA Cross-references UniProtKB/Swiss-Prot Q01986; MP2K1_RAT. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_12 Entry name MP2K1_RAT Primary accession number Q01986 Secondary accession number(s) Q5EBD5 Sequence was last modified on  January 23, 2007 (version 2) Annotations were last modified on  December 14, 2011 (version 109) Name and origin of the protein Description RecName: Full=Dual specificity mitogen-activated protein kinase kinase 1; Short=MAP kinase kinase 1; Short=MAPKK 1; EC=2.7.12.2; AltName: Full=ERK activator kinase 1; AltName: Full=MAPK/ERK kinase 1; Short=MEK 1; Gene name Name=Map2k1 Synonyms=Mek1, Prkmk1 Encoded on Name=Map2k1; Synonyms=Mek1, Prkmk1 Keywords ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL Z16415; CAA78905.1; -; mRNA EMBL D13341; BAA02603.1; -; mRNA EMBL D14591; BAA03441.1; -; mRNA EMBL X62313; CAA44192.1; -; mRNA EMBL BC089772; AAH89772.1; -; mRNA IPI IPI00231247; -; . PIR JN0840; JN0840; . RefSeq NP_113831.1; NM_031643.4; . UniGene Rn.5850; -; . ProteinModelPortal Q01986; -; . SMR Q01986; 62-382; . STRING Q01986; -; . PhosphoSite Q01986; -; . Ensembl ENSRNOT00000013933; ENSRNOP00000013933; ENSRNOG00000010176; . GeneID 170851; -; . KEGG rno:170851; -; . UCSC NM_031643; rat; . CTD 5604; -; . RGD 70495; Map2k1; . eggNOG roNOG05418; -; . GeneTree ENSGT00570000078767; -; . HOVERGEN HBG108518; -; . InParanoid Q01986; -; . OMA DIAGWVC; -; . OrthoDB EOG4SF965; -; . PhylomeDB Q01986; -; . BRENDA 2.7.12.2; 5301; . Reactome REACT_109781; Immune System; . Reactome REACT_111984; Signal Transduction; . Reactome REACT_112697; Developmental Biology; . NextBio 621291; -; . ArrayExpress Q01986; -; . Genevestigator Q01986; -; . GermOnline ENSRNOG00000010176; Rattus norvegicus; . GO GO:0033267; C:axon part; IDA:RGD; . GO GO:0005938; C:cell cortex; IDA:RGD; . GO GO:0005829; C:cytosol; IDA:RGD; . GO GO:0032839; C:dendrite cytoplasm; IDA:RGD; . GO GO:0005794; C:Golgi apparatus; IDA:RGD; . GO GO:0043204; C:perikaryon; IDA:RGD; . GO GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD; . GO GO:0005886; C:plasma membrane; IDA:RGD; . GO GO:0005625; C:soluble fraction; IDA:RGD; . GO GO:0005524; F:ATP binding; IDA:RGD; . GO GO:0004708; F:MAP kinase kinase activity; IDA:RGD; . GO GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IDA:RGD; . GO GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW; . GO GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW; . GO GO:0017016; F:Ras GTPase binding; IPI:RGD; . GO GO:0000187; P:activation of MAPK activity; IDA:RGD; . GO GO:0008283; P:cell proliferation; IDA:RGD; . GO GO:0048313; P:Golgi inheritance; IMP:RGD; . GO GO:0032402; P:melanosome transport; IDA:RGD; . GO GO:0007067; P:mitosis; IDA:RGD; . GO GO:0034111; P:negative regulation of homotypic cell-cell adhesion; IMP:RGD; . GO GO:0048812; P:neuron projection morphogenesis; IMP:RGD; . GO GO:0030335; P:positive regulation of cell migration; IMP:RGD; . GO GO:0032320; P:positive regulation of Ras GTPase activity; IMP:RGD; . GO GO:0046579; P:positive regulation of Ras protein signal transduction; IMP:MGI; . GO GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IMP:RGD; . GO GO:0003056; P:regulation of vascular smooth muscle contraction; IMP:RGD; . GO GO:0048678; P:response to axon injury; IMP:RGD; . GO GO:0051384; P:response to glucocorticoid stimulus; IDA:RGD; . GO GO:0006979; P:response to oxidative stress; IDA:RGD; . GO GO:0047496; P:vesicle transport along microtubule; IDA:RGD; . InterPro IPR011009; Kinase-like_dom; . InterPro IPR000719; Prot_kinase_cat_dom; . InterPro IPR017441; Protein_kinase_ATP_BS; . InterPro IPR017442; Se/Thr_kinase-like_dom; . InterPro IPR008271; Ser/Thr_kinase_AS; . InterPro IPR002290; Ser/Thr_kinase_dom; . KO K04368; -; . Pfam PF00069; Pkinase; 1; . SMART SM00220; S_TKc; 1; . SUPFAM SSF56112; Kinase_like; 1; . PROSITE PS00107; PROTEIN_KINASE_ATP; 1; . PROSITE PS50011; PROTEIN_KINASE_DOM; 1; . PROSITE PS00108; PROTEIN_KINASE_ST; 1; . World-2DPAGE Repository (search AC)