resource logo

World-2DPAGE Repository

Attention: World-2DPAGE is no longer maintained.
It will be discontinued on 31-May-2024.

Swiss-2DPAGE data (text records and image files) will continue to be available from

World-2DPAGE Repository no longer accepts submissions.

World-2DPAGE Repository 
Search by  [accession number] *
[description, ID or gene] 
[author names] 
[spot ID / serial number] 
[identification methods] 
[pI / Mw range] 
[combined fields] 

Maps  [experimental info] 
[protein list] 
[graphical interface]


use 'Ctrl' to select several

Select Remote Interfaces
[All Interfaces]
World-2DPAGE Portal

Exclude local DBs
has only effect if a remote
interface is selected
Searching in 'World-2DPAGE Repository [0030]' for entry matching: NEC1_RAT

World-2DPAGE Repository (0030):  NEC1_RAT


General information about the entry
View entry in simple text format
Entry nameNEC1_RAT
Primary accession numberP28840
integrated into World-2DPAGE Repository (0030) on November 9, 2010 (release 1)
2D Annotations were last modified onJune 21, 2011 (version 2)
General Annotations were last modified on November 23, 2011 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Neuroendocrine convertase 1; Short=NEC 1; EC=; AltName: Full=Prohormone convertase 1; AltName: Full=Proprotein convertase 1; Short=PC1; Flags: Precursor;.
Gene nameName=Pcsk1
Synonyms=Bdp, Nec-1, Nec1
Annotated speciesRattus norvegicus (Rat) [TaxID: 10116]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
D'Hertog W., Maris M., Thorrez L., Waelkens E., Overbergh L., Mathieu C.
''Two-dimensional gel proteome reference map of INS-1E cells''
Proteomics 11(7):1365-1369 (2011)
2D PAGE maps for identified proteins
How to interpret a protein

RAT_INS1E_4-7 {INS-1E cell line, a model rat cell line for pancreatic beta cells, PH4-7}
Rattus norvegicus (Rat)
  map experimental info

pI=5.28; Mw=75563  [identification data]

IDENTIFICATION: SPOT 638: Mascot protein score=72. Number of peptides=4 [1].
MAPPING (identification):
SPOT 638: Tandem mass spectrometry [1].

Data from Dr. Wannes D'Hertog, Catholic University Leuven, Belgium
UniProtKB/Swiss-ProtP28840; NEC1_RAT.
World-2DPAGE RepositoryP28840; NEC1_RAT.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_11
Entry nameNEC1_RAT
Primary accession numberP28840
Sequence was last modified on December 1, 1992 (version 1)
Annotations were last modified on November 16, 2011 (version 103)
Name and origin of the protein
DescriptionRecName: Full=Neuroendocrine convertase 1; Short=NEC 1; EC=; AltName: Full=Prohormone convertase 1; AltName: Full=Proprotein convertase 1; Short=PC1; Flags: Precursor;
Gene nameName=Pcsk1
Synonyms=Bdp, Nec-1, Nec1
Encoded onName=Pcsk1; Synonyms=Bdp, Nec-1, Nec1
KeywordsCalcium; Cleavage on pair of basic residues; Complete proteome; Cytoplasmic vesicle; Disulfide bond; Glycoprotein; Hydrolase; Protease; Reference proteome; Serine protease; Signal; Zymogen.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLM76705; AAA40945.1; -; mRNA
EMBLM83745; AAA41476.1; -; mRNA
IPIIPI00204862; -; .
PIRA41556; KXRTC1; .
RefSeqNP_058787.1; NM_017091.2; .
UniGeneRn.11384; -; .
ProteinModelPortalP28840; -; .
SMRP28840; 31-103; 122-597; .
STRINGP28840; -; .
MEROPSS08.072; -; .
PRIDEP28840; -; .
EnsemblENSRNOT00000015185; ENSRNOP00000015185; ENSRNOG00000011107; .
GeneID25204; -; .
KEGGrno:25204; -; .
UCSCM83745; rat; .
CTD5122; -; .
RGD3272; Pcsk1; .
eggNOGmaNOG04587; -; .
GeneTreeENSGT00600000084064; -; .
HOVERGENHBG008705; -; .
InParanoidP28840; -; .
OrthoDBEOG4K3KVR; -; .
PhylomeDBP28840; -; .
NextBio605733; -; .
ArrayExpressP28840; -; .
GenevestigatorP28840; -; .
GermOnlineENSRNOG00000011107; Rattus norvegicus; .
GOGO:0043679; C:axon terminus; IDA:RGD; .
GOGO:0030425; C:dendrite; IDA:RGD; .
GOGO:0005615; C:extracellular space; IDA:RGD; .
GOGO:0043025; C:neuronal cell body; IDA:RGD; .
GOGO:0048471; C:perinuclear region of cytoplasm; IDA:RGD; .
GOGO:0005791; C:rough endoplasmic reticulum; IDA:RGD; .
GOGO:0030141; C:stored secretory granule; IDA:RGD; .
GOGO:0005802; C:trans-Golgi network; IDA:RGD; .
GOGO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell; .
GOGO:0051087; F:chaperone binding; IPI:RGD; .
GOGO:0043559; F:insulin binding; IPI:RGD; .
GOGO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome; .
GOGO:0009790; P:embryo development; IEP:RGD; .
GOGO:0022008; P:neurogenesis; IEP:RGD; .
GOGO:0031016; P:pancreas development; IEP:RGD; .
GOGO:0016486; P:peptide hormone processing; IDA:RGD; .
GOGO:0021983; P:pituitary gland development; IEP:RGD; .
GOGO:0050714; P:positive regulation of protein secretion; IDA:RGD; .
GOGO:0016540; P:protein autoprocessing; IMP:RGD; .
GOGO:0006508; P:proteolysis; IMP:RGD; .
GOGO:0048678; P:response to axon injury; IEP:RGD; .
GOGO:0051592; P:response to calcium ion; IEP:RGD; .
GOGO:0010157; P:response to chlorate; IEP:RGD; .
GOGO:0042493; P:response to drug; IEP:RGD; .
GOGO:0070542; P:response to fatty acid; IEP:RGD; .
GOGO:0051384; P:response to glucocorticoid stimulus; IEP:RGD; .
GOGO:0009749; P:response to glucose stimulus; IEP:RGD; .
GOGO:0070555; P:response to interleukin-1; IEP:RGD; .
GOGO:0032496; P:response to lipopolysaccharide; IEP:RGD; .
GOGO:0043278; P:response to morphine; IEP:RGD; .
GOGO:0031667; P:response to nutrient levels; IEP:RGD; .
GOGO:0043434; P:response to peptide hormone stimulus; IEP:RGD; .
InterProIPR008979; Galactose-bd-like; .
InterProIPR000209; Peptidase_S8/S53; .
InterProIPR023827; Peptidase_S8_Asp-AS; .
InterProIPR022398; Peptidase_S8_His-AS; .
InterProIPR023828; Peptidase_S8_Ser-AS; .
InterProIPR015500; Peptidase_S8_subtilisin-rel; .
InterProIPR022005; Proho_convert; .
InterProIPR009020; Prot_inh_propept; .
InterProIPR002884; PrprotnconvertsP; .
Gene3DG3DSA:; Pept_S8_S53; 1; .
KOK01359; -; .
PANTHERPTHR10795; SubtilSerProt; 1; .
PfamPF01483; P_proprotein; 1; .
PfamPF00082; Peptidase_S8; 1; .
PfamPF12177; Proho_convert; 1; .
SUPFAMSSF49785; Gal_bind_like; 1; .
SUPFAMSSF52743; Pept_S8_S53; 1; .
SUPFAMSSF54897; Prot_inh_propept; 1; .

World-2DPAGE Repository image

World-2DPAGE Repository (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server