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Searching in 'World-2DPAGE Repository [0030]' for entry matching: P00787

World-2DPAGE Repository (0030):  P00787


General information about the entry
View entry in simple text format
Entry nameCATB_RAT
Primary accession numberP00787
integrated into World-2DPAGE Repository (0030) on November 9, 2010 (release 1)
2D Annotations were last modified onJune 21, 2011 (version 2)
General Annotations were last modified on November 23, 2011 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Cathepsin B; EC=; AltName: Full=Cathepsin B1; AltName: Full=RSG-2; Contains: RecName: Full=Cathepsin B light chain; Contains: RecName: Full=Cathepsin B heavy chain; Flags: Precursor;.
Gene nameName=Ctsb
Annotated speciesRattus norvegicus (Rat) [TaxID: 10116]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
D'Hertog W., Maris M., Thorrez L., Waelkens E., Overbergh L., Mathieu C.
''Two-dimensional gel proteome reference map of INS-1E cells''
Proteomics 11(7):1365-1369 (2011)
2D PAGE maps for identified proteins
How to interpret a protein

RAT_INS1E_4-7 {INS-1E cell line, a model rat cell line for pancreatic beta cells, PH4-7}
Rattus norvegicus (Rat)
  map experimental info

pI=5.07; Mw=29660  [identification data]

IDENTIFICATION: SPOT 2062: Mascot protein score=302. Number of peptides=6 [1].
MAPPING (identification):
SPOT 2062: Tandem mass spectrometry [1].

Data from Dr. Wannes D'Hertog, Catholic University Leuven, Belgium
UniProtKB/Swiss-ProtP00787; CATB_RAT.
World-2DPAGE RepositoryP00787; CATB_RAT.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_11
Entry nameCATB_RAT
Primary accession numberP00787
Sequence was last modified on October 1, 1996 (version 2)
Annotations were last modified on October 19, 2011 (version 120)
Name and origin of the protein
DescriptionRecName: Full=Cathepsin B; EC=; AltName: Full=Cathepsin B1; AltName: Full=RSG-2; Contains: RecName: Full=Cathepsin B light chain; Contains: RecName: Full=Cathepsin B heavy chain; Flags: Precursor;
Gene nameName=Ctsb
Encoded onName=Ctsb
Keywords3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Protease; Reference proteome; Signal; Thiol protease; Zymogen.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLX82396; CAA57792.1; -; mRNA
EMBLM11305; AAA40993.1; -; mRNA
IPIIPI00212811; -; .
PIRS51041; KHRTB; .
UniGeneRn.100909; -; .
PDB1CPJ; X-ray; 2.20 A; A/B=74-333
PDB1CTE; X-ray; 2.10 A; A/B=80-333
PDB1MIR; X-ray; 2.80 A; A/B=18-339
PDB1THE; X-ray; 1.90 A; A/B=74-333
PDBsum1CPJ; -; .
PDBsum1CTE; -; .
PDBsum1MIR; -; .
PDBsum1THE; -; .
ProteinModelPortalP00787; -; .
SMRP00787; 27-339; .
STRINGP00787; -; .
MEROPSC01.060; -; .
PRIDEP00787; -; .
UCSCNM_022597; rat; .
RGD621509; Ctsb; .
eggNOGroNOG08540; -; .
HOVERGENHBG003480; -; .
InParanoidP00787; -; .
OrthoDBEOG4K6G4C; -; .
BRENDA3.4.22.1; 5301; .
ArrayExpressP00787; -; .
GenevestigatorP00787; -; .
GermOnlineENSRNOG00000010331; Rattus norvegicus; .
GOGO:0016324; C:apical plasma membrane; IDA:RGD; .
GOGO:0009897; C:external side of plasma membrane; IDA:RGD; .
GOGO:0005615; C:extracellular space; IDA:RGD; .
GOGO:0005764; C:lysosome; IDA:RGD; .
GOGO:0042470; C:melanosome; IEA:UniProtKB-SubCell; .
GOGO:0005739; C:mitochondrion; IDA:RGD; .
GOGO:0042383; C:sarcolemma; IDA:RGD; .
GOGO:0005625; C:soluble fraction; IDA:RGD; .
GOGO:0004197; F:cysteine-type endopeptidase activity; IDA:RGD; .
GOGO:0030984; F:kininogen binding; IPI:RGD; .
GOGO:0042277; F:peptide binding; IDA:RGD; .
GOGO:0006914; P:autophagy; IEP:RGD; .
GOGO:0060548; P:negative regulation of cell death; IMP:RGD; .
GOGO:0006508; P:proteolysis; IDA:RGD; .
GOGO:0050790; P:regulation of catalytic activity; IEA:InterPro; .
GOGO:0014075; P:response to amine stimulus; IEP:RGD; .
GOGO:0045471; P:response to ethanol; IEP:RGD; .
GOGO:0009749; P:response to glucose stimulus; IEP:RGD; .
GOGO:0070670; P:response to interleukin-4; IEP:RGD; .
GOGO:0009612; P:response to mechanical stimulus; IEP:RGD; .
GOGO:0014070; P:response to organic cyclic compound; IEP:RGD; .
GOGO:0043434; P:response to peptide hormone stimulus; IEP:RGD; .
GOGO:0009611; P:response to wounding; IEP:RGD; .
GOGO:0007519; P:skeletal muscle tissue development; IEP:RGD; .
InterProIPR000169; Pept_cys_AS; .
InterProIPR013128; Peptidase_C1A; .
InterProIPR000668; Peptidase_C1A_C; .
InterProIPR015643; Peptidase_C1A_cathepsin-B; .
InterProIPR012599; Propeptide_C1A; .
PANTHERPTHR12411:SF16; CathepsinB_like; 1; .
PANTHERPTHR12411; Peptidase_C1A; 1; .
PfamPF00112; Peptidase_C1; 1; .
PfamPF08127; Propeptide_C1; 1; .
SMARTSM00645; Pept_C1; 1; .

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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server