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Searching in 'World-2DPAGE Repository [0027]' for entry matching: P01029

World-2DPAGE Repository (0027):  P01029


General information about the entry
View entry in simple text format
Entry nameCO4B_MOUSE
Primary accession numberP01029
integrated into World-2DPAGE Repository (0027) on September 30, 2010 (release 1)
2D Annotations were last modified onJune 21, 2011 (version 2)
General Annotations were last modified on November 23, 2011 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Complement C4-B; Contains: RecName: Full=Complement C4 beta chain; Contains: RecName: Full=Complement C4 alpha chain; Contains: RecName: Full=C4a anaphylatoxin; Contains: RecName: Full=Complement C4 gamma chain; Flags: Precursor;.
Gene nameName=C4b
Annotated speciesMus musculus (Mouse) [TaxID: 10090]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus.
Blutke A., Block C., Berendt F., Herbach N., Kemter E., Amann K., Frolich T., Arnold G.J., Wanke R.
''Differential glomerular proteome analysis of two murine nephropathy models at onset of albuminuria''
Proteomics - Clinical Applications 5(6):375-381 (2011)
2D PAGE maps for identified proteins
How to interpret a protein

GIPRDN_4-7 {glomerular protein lysates of a GIPRdn-tg animal}
Mus musculus (Mouse)
  map experimental info

pI=6.44; Mw=22000  [identification data]

SPOT 35: Avg ratio GIPRdn-tg vs. control=2.2 (p-value=0.0053) [1].

IDENTIFICATION: SPOT 35: SeqCov=8%. Mascot protein score=82 [1].
MAPPING (identification):
SPOT 35: Peptide mass fingerprinting [1].

Data from Dr. Andreas Blutke, Institute of Veterinary Pathology, University Munich, Germany
UniProtKB/Swiss-ProtP01029; CO4B_MOUSE.
World-2DPAGE RepositoryP01029; CO4B_MOUSE.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_11
Entry nameCO4B_MOUSE
Primary accession numberP01029
Secondary accession number(s) E9QKK7 O70346 Q31201 Q3TYY1 Q3TZC9 Q61372 Q61859 Q62353 Q6NWV8
Sequence was last modified on July 27, 2011 (version 3)
Annotations were last modified on November 16, 2011 (version 126)
Name and origin of the protein
DescriptionRecName: Full=Complement C4-B; Contains: RecName: Full=Complement C4 beta chain; Contains: RecName: Full=Complement C4 alpha chain; Contains: RecName: Full=C4a anaphylatoxin; Contains: RecName: Full=Complement C4 gamma chain; Flags: Precursor;
Gene nameName=C4b
Encoded onName=C4b; Synonyms=C4
KeywordsCleavage on pair of basic residues; Complement pathway; Complete proteome; Disulfide bond; Glycoprotein; Immunity; Inflammatory response; Innate immunity; Reference proteome; Secreted; Signal; Sulfation; Thioester bond.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLM11789; AAA39557.1; -; Genomic_DNA
EMBLM11729; AAA39506.1; -; mRNA
EMBLM17440; AAA39561.1; -; Genomic_DNA
EMBLAK157954; BAE34280.1; -; mRNA
EMBLAK158256; BAE34429.1; -; mRNA
EMBLAF049850; AAC05279.1; -; Genomic_DNA
EMBLBC067394; AAH67394.1; -; mRNA
EMBLBC067409; AAH67409.1; -; mRNA
EMBLM12968; AAA39558.1; -; Genomic_DNA
EMBLM12969; AAA39559.1; -; Genomic_DNA
EMBLM14225; AAA39563.1; -; Genomic_DNA
EMBLX05314; CAA28936.1; -; mRNA
EMBLM12970; AAA39555.1; -; mRNA
EMBLM12972; AAA39556.1; -; mRNA
EMBLM23186; AAA40487.1; -; Genomic_DNA
EMBLX55493; CAA39112.1; -; Genomic_DNA
EMBLX55495; CAA39114.1; -; Genomic_DNA
EMBLK02798; AAC42021.1; -; mRNA
EMBLK02799; AAC42022.1; -; mRNA
EMBLK00019; AAA39554.1; -; mRNA
IPIIPI00131091; -; .
PIRA24558; A24558; .
PIRA29176; A29176; .
RefSeqNP_033910.2; NM_009780.2; .
RefSeqXP_978162.1; XM_973068.2; .
UniGeneMm.439678; -; .
UniGeneMm.477109; -; .
ProteinModelPortalP01029; -; .
SMRP01029; 992-1317; .
STRINGP01029; -; .
MEROPSI39.951; -; .
PhosphoSiteP01029; -; .
PRIDEP01029; -; .
EnsemblENSMUST00000069507; ENSMUSP00000069418; ENSMUSG00000073418; .
GeneID12268; -; .
GeneID675521; -; .
KEGGmmu:12268; -; .
KEGGmmu:675521; -; .
CTD721; -; .
MGIMGI:88228; C4b; .
eggNOGroNOG10450; -; .
HOVERGENHBG107123; -; .
InParanoidP01029; -; .
OrthoDBEOG4JM7NW; -; .
NextBio280722; -; .
BgeeP01029; -; .
CleanExMM_C4B; -; .
GenevestigatorP01029; -; .
GermOnlineENSMUSG00000073418; Mus musculus; .
GOGO:0005615; C:extracellular space; IEA:InterPro; .
GOGO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro; .
GOGO:0006958; P:complement activation; classical pathway; IEA:UniProtKB-KW
GOGO:0006954; P:inflammatory response; IEA:UniProtKB-KW; .
GOGO:0045087; P:innate immune response; IEA:UniProtKB-KW; .
InterProIPR009048; A-macroglobulin_rcpt-bd; .
InterProIPR011626; A2M_comp; .
InterProIPR002890; A2M_N; .
InterProIPR011625; A2M_N_2; .
InterProIPR000020; Anaphylatoxin/fibulin; .
InterProIPR018081; Anaphylatoxin_; .
InterProIPR001840; Anaphylatoxn; .
InterProIPR001599; Macroglobln_a2; .
InterProIPR019742; MacrogloblnA2_CS; .
InterProIPR019565; MacrogloblnA2_thiol-ester-bond; .
InterProIPR001134; Netrin_domain; .
InterProIPR018933; Netrin_module_non-TIMP; .
InterProIPR008930; Terpenoid_cyclase/PrenylTrfase; .
InterProIPR008993; TIMP-like_OB-fold; .
Gene3DG3DSA:; A-macroglobulin_rcpt-bd; 1; .
Gene3DG3DSA:; Anaphylatoxin; 1; .
KOK03989; -; .
PfamPF00207; A2M; 1; .
PfamPF07678; A2M_comp; 1; .
PfamPF01835; A2M_N; 1; .
PfamPF07703; A2M_N_2; 1; .
PfamPF07677; A2M_recep; 1; .
PfamPF01821; ANATO; 1; .
PfamPF01759; NTR; 1; .
PfamPF10569; Thiol-ester_cl; 1; .
SMARTSM00104; ANATO; 1; .
SMARTSM00643; C345C; 1; .
SUPFAMSSF49410; AM_receptor_bind; 1; .
SUPFAMSSF47686; Anaphylatoxin; 1; .
SUPFAMSSF48239; Terp_cyc_toroid; 1; .
SUPFAMSSF50242; TIMP_like; 1; .
PROSITEPS50189; NTR; 1; .

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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server