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Searching in 'World-2DPAGE Repository [0022]' for entry matching: P04639

World-2DPAGE Repository (0022):  P04639


General information about the entry
View entry in simple text format
Entry nameAPOA1_RAT
Primary accession numberP04639
integrated into World-2DPAGE Repository (0022) on May 7, 2010 (release 1)
2D Annotations were last modified onJune 22, 2011 (version 2)
General Annotations were last modified on November 24, 2011 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Apolipoprotein A-I; Short=Apo-AI; Short=ApoA-I; AltName: Full=Apolipoprotein A1; Flags: Precursor;.
Gene nameName=Apoa1
Annotated speciesRattus [TaxID: 10114]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae.
Burniston J.G., Kenyani J., Wastling J.M., Burant C.F., Qi N.R., Koch L.G., Britton S.L.
''Proteomic analysis reveals perturbed energy metabolism and elevated oxidative stress in hearts of rats with inborn low aerobic capacity''
Proteomics 11(16):3369-3379 (2011)
2D PAGE maps for identified proteins
How to interpret a protein

Tissue: Heart
  map experimental info

pI=5.52; Mw=30100  [identification data]

IDENTIFICATION: SPOT 443: SeqCov=29.7%. Peptides MS=9/20. Mascot PMF Score=55 [1].
PEPTIDE EVIDENCE: SPOT 443: 162-VVAEEFR-168 (34): 131-WNEEVEAYR-139 (75): 64-QLNLNLLDNWDTLGSTVGR-82 (15) [1].
MAPPING (identification):
SPOT 443: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Data from Dr. Jatin Burniston, Liverpool John Moores University, UK
UniProtKB/Swiss-ProtP04639; APOA1_RAT.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_11
Entry nameAPOA1_RAT
Primary accession numberP04639
Secondary accession number(s) O08877 O09054 Q5EBB2
Sequence was last modified on May 1, 2007 (version 2)
Annotations were last modified on November 16, 2011 (version 87)
Name and origin of the protein
DescriptionRecName: Full=Apolipoprotein A-I; Short=Apo-AI; Short=ApoA-I; AltName: Full=Apolipoprotein A1; Flags: Precursor;
Gene nameName=Apoa1
Encoded onName=Apoa1
KeywordsCholesterol metabolism; Complete proteome; Direct protein sequencing; HDL; Lipid metabolism; Lipid transport; Phosphoprotein; Reference proteome; Repeat; Secreted; Signal; Steroid metabolism; Transport.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLM00001; AAA40749.1; -; mRNA
EMBLX00558; CAA25224.1; -; mRNA
EMBLJ02597; AAA40745.1; -; Genomic_DNA
EMBLU79576; AAB58428.1; -; Genomic_DNA
EMBLU79577; AAB58429.1; -; Genomic_DNA
EMBLU79578; AAB58430.1; -; Genomic_DNA
EMBLBC089820; AAH89820.1; -; mRNA
IPIIPI00197703; -; .
PIRA24700; A24700; .
RefSeqNP_036870.1; NM_012738.1; .
UniGeneRn.10308; -; .
ProteinModelPortalP04639; -; .
SMRP04639; 25-258; .
DIPDIP-29911N; -; .
IntActP04639; 1; .
PRIDEP04639; -; .
GeneID25081; -; .
KEGGrno:25081; -; .
CTD335; -; .
RGD2130; Apoa1; .
HOVERGENHBG105708; -; .
NextBio605334; -; .
GenevestigatorP04639; -; .
GOGO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW; .
GOGO:0005634; C:nucleus; IDA:RGD; .
GOGO:0017127; F:cholesterol transporter activity; IDA:RGD; .
GOGO:0055102; F:lipase inhibitor activity; IDA:RGD; .
GOGO:0008289; F:lipid binding; IEA:InterPro; .
GOGO:0005548; F:phospholipid transporter activity; IDA:RGD; .
GOGO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW; .
GOGO:0042157; P:lipoprotein metabolic process; IEA:InterPro; .
GOGO:0060192; P:negative regulation of lipase activity; IDA:RGD; .
GOGO:0031100; P:organ regeneration; IDA:RGD; .
GOGO:0014012; P:peripheral nervous system axon regeneration; IEP:RGD; .
GOGO:0042493; P:response to drug; IEP:RGD; .
GOGO:0043627; P:response to estrogen stimulus; IEP:RGD; .
GOGO:0007584; P:response to nutrient; IEP:RGD; .
InterProIPR013326; ApoA/E_ApoLp; .
InterProIPR000074; ApoA1_A4_E; .
Gene3DG3DSA:; ApoA/E_ApoLp; 1; .
KOK08757; -; .
PfamPF01442; Apolipoprotein; 1; .

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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server