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Searching in 'World-2DPAGE Repository [0019]' for entry matching: P04785




World-2DPAGE Repository (0019):  P04785


P04785


General information about the entry
View entry in simple text format
Entry namePDIA1_RAT
Primary accession numberP04785
integrated into World-2DPAGE Repository (0019) on December 9, 2009 (release 1)
2D Annotations were last modified onMay 30, 2011 (version 2)
General Annotations were last modified on January 13, 2012 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Protein disulfide-isomerase; Short=PDI; EC=5.3.4.1; AltName: Full=Cellular thyroid hormone-binding protein; AltName: Full=Prolyl 4-hydroxylase subunit beta; Flags: Precursor;.
Gene nameName=P4hb
Synonyms=Pdia1
Annotated speciesRattus norvegicus (Rat) [TaxID: 10116]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
References
[1]   2D-PAGE GEL CHARACTERIZATION
DOI=10.1111/j.1471-4159.2010.06719.x;
VanGuilder H.D., Yan H., Farley J.A., Sonntag W.E., Freeman W.M.
''Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome''
J of Neurochemistry 113(6):1577-1588 (2010)
2D PAGE maps for identified proteins
How to interpret a protein

HIPP_SYNAP {Rat hippocampal synaptoproteome}
Rattus norvegicus (Rat)
Tissue: Hippocampus
HIPP_SYNAP
  map experimental info
 
HIPP_SYNAP

MAP LOCATIONS:
pI=4.82; Mw=56951  [identification data]

IDENTIFICATION: SPOT 1009: Peptides number=36. SeqCov=66%. MOWSE score=4.96E+22 [1].
MAPPING (identification):
SPOT 1009: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Copyright
Data from Dr. Willard Freeman, Penn State College of Medicine, USA
Cross-references
UniProtKB/Swiss-ProtP04785; PDIA1_RAT.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_12
Entry namePDIA1_RAT
Primary accession numberP04785
Secondary accession number(s) P13700
Sequence was last modified on October 1, 1989 (version 2)
Annotations were last modified on November 16, 2011 (version 125)
Name and origin of the protein
DescriptionRecName: Full=Protein disulfide-isomerase; Short=PDI; EC=5.3.4.1; AltName: Full=Cellular thyroid hormone-binding protein; AltName: Full=Prolyl 4-hydroxylase subunit beta; Flags: Precursor;
Gene nameName=P4hb
Synonyms=Pdia1
Encoded onName=P4hb; Synonyms=Pdia1
KeywordsCell membrane; Chaperone; Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Isomerase; Membrane; Redox-active center; Reference proteome; Repeat; Signal.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM21018; AAA40620.1; -; mRNA
EMBLBC061857; AAH61857.1; -; mRNA
EMBLX02918; CAA26675.1; -; mRNA
EMBLM21476; AAA40619.1; -; mRNA
IPIIPI00198887; -; .
PIRA24595; ISRTSS; .
PIRS68028; S68028; .
RefSeqNP_037130.1; NM_012998.1; .
UniGeneRn.4234; -; .
ProteinModelPortalP04785; -; .
SMRP04785; 20-359; 370-473; .
IntActP04785; 1; .
STRINGP04785; -; .
PhosphoSiteP04785; -; .
PRIDEP04785; -; .
EnsemblENSRNOT00000054958; ENSRNOP00000051841; ENSRNOG00000036689; .
GeneID25506; -; .
KEGGrno:25506; -; .
UCSCNM_012998; rat; .
CTD5034; -; .
RGD3244; P4hb; .
eggNOGroNOG08939; -; .
GeneTreeENSGT00590000082936; -; .
HOVERGENHBG005920; -; .
InParanoidP04785; -; .
OMALMSQDLP; -; .
OrthoDBEOG4JWVDB; -; .
PhylomeDBP04785; -; .
NextBio606925; -; .
GenevestigatorP04785; -; .
GermOnlineENSRNOG00000036689; Rattus norvegicus; .
GOGO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell; .
GOGO:0042470; C:melanosome; IEA:UniProtKB-SubCell; .
GOGO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell; .
GOGO:0009055; F:electron carrier activity; IEA:InterPro; .
GOGO:0003756; F:protein disulfide isomerase activity; IMP:RGD; .
GOGO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro; .
GOGO:0046982; F:protein heterodimerization activity; IPI:RGD; .
GOGO:0045454; P:cell redox homeostasis; IEA:InterPro; .
GOGO:0006662; P:glycerol ether metabolic process; IEA:InterPro; .
InterProIPR005788; Disulphide_isomerase; .
InterProIPR005792; Prot_disulphide_isomerase; .
InterProIPR005746; Thioredoxin; .
InterProIPR012336; Thioredoxin-like_fold; .
InterProIPR017937; Thioredoxin_CS; .
InterProIPR013766; Thioredoxin_domain; .
Gene3DG3DSA:3.40.30.10; Thioredoxin_fold; 3; .
KOK09580; -; .
PfamPF00085; Thioredoxin; 2; .
PRINTSPR00421; THIOREDOXIN; .
SUPFAMSSF52833; Thiordxn-like_fd; 4; .
TIGRFAMsTIGR01130; ER_PDI_fam; 1; .
TIGRFAMsTIGR01126; Pdi_dom; 2; .
PROSITEPS00014; ER_TARGET; 1; .
PROSITEPS00194; THIOREDOXIN_1; 2; .
PROSITEPS51352; THIOREDOXIN_2; 2; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server