World-2DPAGE Repository
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World-2DPAGE Repository
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World-2DPAGE Portal
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Searching in 'World-2DPAGE Repository [0019]' for entry
matching:
P04785
World-2DPAGE Repository
(0019):
P04785
P04785
General information about the entry
View entry in simple text format
Entry name
PDIA1_RAT
Primary accession number
P04785
integrated into World-2DPAGE Repository (0019) on
December 9, 2009 (release 1)
2D Annotations were last modified on
May 30, 2011 (version 2)
General Annotations were last modified on
January 13, 2012 (version 2)
Name and origin of the protein
Description
RecName: Full=Protein disulfide-isomerase; Short=PDI; EC=5.3.4.1; AltName: Full=Cellular thyroid hormone-binding protein; AltName: Full=Prolyl 4-hydroxylase subunit beta; Flags: Precursor;.
Gene name
Name=P4hb
Synonyms=Pdia1
Annotated species
Rattus norvegicus (Rat) [TaxID:
10116
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
References
[1]
2D-PAGE GEL CHARACTERIZATION
DOI=
10.1111/j.1471-4159.2010.06719.x
;
VanGuilder H.D., Yan H., Farley J.A., Sonntag W.E., Freeman W.M.
''Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome''
J of Neurochemistry 113(6):1577-1588 (2010)
2D PAGE maps for identified proteins
How to interpret a protein
HIPP_SYNAP
{Rat hippocampal synaptoproteome}
Rattus norvegicus (Rat)
Tissue: Hippocampus
map experimental info
HIPP_SYNAP
MAP LOCATIONS:
SPOT 1009
:
pI=4.82; Mw=56951
[identification data]
IDENTIFICATION:
SPOT 1009: Peptides number=36. SeqCov=66%. MOWSE score=4.96E+22 [
1
].
MAPPING (identification):
SPOT
1009
:
Peptide mass fingerprinting
[
1
];
Tandem mass spectrometry
[
1
].
Copyright
Data from Dr. Willard Freeman, Penn State College of Medicine, USA
Cross-references
UniProtKB/Swiss-Prot
P04785; PDIA1_RAT.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
2011_12
Entry name
PDIA1_RAT
Primary accession number
P04785
Secondary accession number(s)
P13700
Sequence was last modified on
October 1, 1989 (version 2)
Annotations were last modified on
November 16, 2011 (version 125)
Name and origin of the protein
Description
RecName: Full=Protein disulfide-isomerase; Short=PDI; EC=5.3.4.1; AltName: Full=Cellular thyroid hormone-binding protein; AltName: Full=Prolyl 4-hydroxylase subunit beta; Flags: Precursor;
Gene name
Name=P4hb
Synonyms=Pdia1
Encoded on
Name=P4hb; Synonyms=Pdia1
Keywords
Cell membrane
;
Chaperone
;
Complete proteome
;
Direct protein sequencing
;
Disulfide bond
;
Endoplasmic reticulum
;
Isomerase
;
Membrane
;
Redox-active center
;
Reference proteome
;
Repeat
;
Signal
.
Copyright
Copyrighted by the UniProt Consortium, see
https://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
M21018; AAA40620.1
; -; mRNA
EMBL
BC061857; AAH61857.1
; -; mRNA
EMBL
X02918; CAA26675.1
; -; mRNA
EMBL
M21476; AAA40619.1
; -; mRNA
IPI
IPI00198887; -
; .
PIR
A24595; ISRTSS
; .
PIR
S68028; S68028
; .
RefSeq
NP_037130.1; NM_012998.1
; .
UniGene
Rn.4234; -
; .
ProteinModelPortal
P04785; -
; .
SMR
P04785; 20-359
; 370-473; .
IntAct
P04785; 1
; .
STRING
P04785; -
; .
PhosphoSite
P04785; -
; .
PRIDE
P04785; -
; .
Ensembl
ENSRNOT00000054958; ENSRNOP00000051841
; ENSRNOG00000036689; .
GeneID
25506; -
; .
KEGG
rno:25506; -
; .
UCSC
NM_012998; rat
; .
CTD
5034; -
; .
RGD
3244; P4hb
; .
eggNOG
roNOG08939; -
; .
GeneTree
ENSGT00590000082936; -
; .
HOVERGEN
HBG005920; -
; .
InParanoid
P04785; -
; .
OMA
LMSQDLP; -
; .
OrthoDB
EOG4JWVDB; -
; .
PhylomeDB
P04785; -
; .
NextBio
606925; -
; .
Genevestigator
P04785; -
; .
GermOnline
ENSRNOG00000036689; Rattus norvegicus
; .
GO
GO:0005788; C:endoplasmic reticulum lumen
; IEA:UniProtKB-SubCell; .
GO
GO:0042470; C:melanosome
; IEA:UniProtKB-SubCell; .
GO
GO:0005886; C:plasma membrane
; IEA:UniProtKB-SubCell; .
GO
GO:0009055; F:electron carrier activity
; IEA:InterPro; .
GO
GO:0003756; F:protein disulfide isomerase activity
; IMP:RGD; .
GO
GO:0015035; F:protein disulfide oxidoreductase activity
; IEA:InterPro; .
GO
GO:0046982; F:protein heterodimerization activity
; IPI:RGD; .
GO
GO:0045454; P:cell redox homeostasis
; IEA:InterPro; .
GO
GO:0006662; P:glycerol ether metabolic process
; IEA:InterPro; .
InterPro
IPR005788; Disulphide_isomerase
; .
InterPro
IPR005792; Prot_disulphide_isomerase
; .
InterPro
IPR005746; Thioredoxin
; .
InterPro
IPR012336; Thioredoxin-like_fold
; .
InterPro
IPR017937; Thioredoxin_CS
; .
InterPro
IPR013766; Thioredoxin_domain
; .
Gene3D
G3DSA:3.40.30.10; Thioredoxin_fold
; 3; .
KO
K09580; -
; .
Pfam
PF00085; Thioredoxin
; 2; .
PRINTS
PR00421; THIOREDOXIN
; .
SUPFAM
SSF52833; Thiordxn-like_fd
; 4; .
TIGRFAMs
TIGR01130; ER_PDI_fam
; 1; .
TIGRFAMs
TIGR01126; Pdi_dom
; 2; .
PROSITE
PS00014; ER_TARGET
; 1; .
PROSITE
PS00194; THIOREDOXIN_1
; 2; .
PROSITE
PS51352; THIOREDOXIN_2
; 2; .
World-2DPAGE Repository (search AC)
Database constructed and maintained by
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, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
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