World-2DPAGE Repository

RecName: Full=Protein disulfide-isomerase; Short=PDI; EC=5.3.4.1; AltName: Full=Cellular thyroid hormone-binding protein; AltName: Full=Prolyl 4-hydroxylase subunit beta; Flags: Precursor;.

Gene name

Name=P4hb
Synonyms=Pdia1

Annotated species

Rattus norvegicus (Rat) [TaxID: 10116]

Taxonomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.

References

[1]	2D-PAGE GEL CHARACTERIZATION DOI=10.1111/j.1471-4159.2010.06719.x; VanGuilder H.D., Yan H., Farley J.A., Sonntag W.E., Freeman W.M. ''Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome'' J of Neurochemistry 113(6):1577-1588 (2010)

2D PAGE maps for identified proteins

How to interpret a protein

HIPP_SYNAP {Rat hippocampal synaptoproteome}
Rattus norvegicus (Rat)
Tissue: Hippocampus

map experimental info

HIPP_SYNAP

MAP LOCATIONS:

SPOT 1009:

pI=4.82; Mw=56951

[identification data]

IDENTIFICATION: SPOT 1009: Peptides number=36. SeqCov=66%. MOWSE score=4.96E+22 [1].
MAPPING (identification):

SPOT 1009: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Copyright

Data from Dr. Willard Freeman, Penn State College of Medicine, USA

Cross-references

UniProtKB/Swiss-Prot

P04785; PDIA1_RAT.

2D PAGE maps for identified proteins
How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_12
Entry name	PDIA1_RAT
Primary accession number	P04785
Secondary accession number(s)	P13700
Sequence was last modified on	October 1, 1989 (version 2)
Annotations were last modified on	November 16, 2011 (version 125)
Name and origin of the protein
Description	RecName: Full=Protein disulfide-isomerase; Short=PDI; EC=5.3.4.1; AltName: Full=Cellular thyroid hormone-binding protein; AltName: Full=Prolyl 4-hydroxylase subunit beta; Flags: Precursor;
Gene name	Name=P4hb Synonyms=Pdia1
Encoded on	Name=P4hb; Synonyms=Pdia1
Keywords	Cell membrane; Chaperone; Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Isomerase; Membrane; Redox-active center; Reference proteome; Repeat; Signal.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL	M21018; AAA40620.1; -; mRNA
EMBL	BC061857; AAH61857.1; -; mRNA
EMBL	X02918; CAA26675.1; -; mRNA
EMBL	M21476; AAA40619.1; -; mRNA
IPI	IPI00198887; -; .
PIR	A24595; ISRTSS; .
PIR	S68028; S68028; .
RefSeq	NP_037130.1; NM_012998.1; .
UniGene	Rn.4234; -; .
ProteinModelPortal	P04785; -; .
SMR	P04785; 20-359; 370-473; .
IntAct	P04785; 1; .
STRING	P04785; -; .
PhosphoSite	P04785; -; .
PRIDE	P04785; -; .
Ensembl	ENSRNOT00000054958; ENSRNOP00000051841; ENSRNOG00000036689; .
GeneID	25506; -; .
KEGG	rno:25506; -; .
UCSC	NM_012998; rat; .
CTD	5034; -; .
RGD	3244; P4hb; .
eggNOG	roNOG08939; -; .
GeneTree	ENSGT00590000082936; -; .
HOVERGEN	HBG005920; -; .
InParanoid	P04785; -; .
OMA	LMSQDLP; -; .
OrthoDB	EOG4JWVDB; -; .
PhylomeDB	P04785; -; .
NextBio	606925; -; .
Genevestigator	P04785; -; .
GermOnline	ENSRNOG00000036689; Rattus norvegicus; .
GO	GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell; .
GO	GO:0042470; C:melanosome; IEA:UniProtKB-SubCell; .
GO	GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell; .
GO	GO:0009055; F:electron carrier activity; IEA:InterPro; .
GO	GO:0003756; F:protein disulfide isomerase activity; IMP:RGD; .
GO	GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro; .
GO	GO:0046982; F:protein heterodimerization activity; IPI:RGD; .
GO	GO:0045454; P:cell redox homeostasis; IEA:InterPro; .
GO	GO:0006662; P:glycerol ether metabolic process; IEA:InterPro; .
InterPro	IPR005788; Disulphide_isomerase; .
InterPro	IPR005792; Prot_disulphide_isomerase; .
InterPro	IPR005746; Thioredoxin; .
InterPro	IPR012336; Thioredoxin-like_fold; .
InterPro	IPR017937; Thioredoxin_CS; .
InterPro	IPR013766; Thioredoxin_domain; .
Gene3D	G3DSA:3.40.30.10; Thioredoxin_fold; 3; .
KO	K09580; -; .
Pfam	PF00085; Thioredoxin; 2; .
PRINTS	PR00421; THIOREDOXIN; .
SUPFAM	SSF52833; Thiordxn-like_fd; 4; .
TIGRFAMs	TIGR01130; ER_PDI_fam; 1; .
TIGRFAMs	TIGR01126; Pdi_dom; 2; .
PROSITE	PS00014; ER_TARGET; 1; .
PROSITE	PS00194; THIOREDOXIN_1; 2; .
PROSITE	PS51352; THIOREDOXIN_2; 2; .

World-2DPAGE Repository (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

0001
0002
0003
0004
0005
0006
0007
0008
0009
0010
0011
0012
0014
0017
0018
0019
0020
0021
0022
0023
0024
0026
0027
0029
0030
0031
0032
0034
0035
0036
0037
0038
0039
0040
0042
0043
0044
0046
0047
0050
0051
0053
0054
0056
0059
0061
0062
0063
0066
0068
0069
0076
0077
0080
0084
0085
0088