World-2DPAGE Repository

RecName: Full=Aldehyde dehydrogenase, mitochondrial; EC=1.2.1.3; AltName: Full=ALDH class 2; AltName: Full=ALDH-E2; AltName: Full=ALDH1; Flags: Precursor;.

Gene name

Name=Aldh2

Annotated species

Rattus norvegicus (Rat) [TaxID: 10116]

Taxonomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.

References

[1]	2D-PAGE GEL CHARACTERIZATION DOI=10.1002/pmic.200900680; Maurya D.K., Sundaram C.S., Bhargava P. ''Proteome profile of whole cerebellum of the mature rat'' Proteomics 10(23):4311-4319 (2010)

2D PAGE maps for identified proteins

How to interpret a protein

RAT_CEREBELLUM_21D {Proteome of 21 days old rat cerebellum}
Rattus norvegicus (Rat)
Tissue: Cerebellum

map experimental info

RAT_CEREBELLUM_21D

MAP LOCATIONS:

SPOT 3365:

pI=6.74; Mw=58000

[identification data]

IDENTIFICATION: SPOT 3365: SeqCov=23%. MascotPMF=70 [1].
MAPPING (identification):

SPOT 3365: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Copyright

Data from Dr. Purnima Bhargava, Centre for Cellular and Molecular Biology, India

Cross-references

PRIDE

10017.

UniProtKB/Swiss-Prot

P11884; ALDH2_RAT.

2D PAGE maps for identified proteins
How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_11
Entry name	ALDH2_RAT
Primary accession number	P11884
Secondary accession number(s)	Q6Q288 Q6Q289 Q6Q290 Q8K3V8 Q91ZD7
Sequence was last modified on	October 1, 1989 (version 1)
Annotations were last modified on	November 16, 2011 (version 115)
Name and origin of the protein
Description	RecName: Full=Aldehyde dehydrogenase, mitochondrial; EC=1.2.1.3; AltName: Full=ALDH class 2; AltName: Full=ALDH-E2; AltName: Full=ALDH1; Flags: Precursor;
Gene name	Name=Aldh2
Encoded on	Name=Aldh2
Keywords	3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Mitochondrion; NAD; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL	X14977; CAA33101.1; -; mRNA
EMBL	BC062081; AAH62081.1; -; mRNA
EMBL	M19030; AAA40719.1; -; mRNA
EMBL	AY566467; AAS75813.1; -; mRNA
EMBL	AY566468; AAS75814.1; -; mRNA
EMBL	AY566469; AAS75815.1; -; mRNA
EMBL	AF529165; AAM94394.2; -; mRNA
EMBL	AY034137; AAK57732.1; -; Genomic_DNA
IPI	IPI00197770; -; .
PIR	S03564; S03564; .
RefSeq	NP_115792.1; NM_032416.1; .
UniGene	Rn.101781; -; .
PDB	1OM2; NMR; -; B=12-20
PDB	2V1S; X-ray; 2.05 A; H/I/J/K/L/M/N=12-20
PDB	2V1T; X-ray; 1.92 A; C/D=12-22
PDB	3AWR; X-ray; 2.00 A; C/D=12-20
PDB	3AX2; X-ray; 1.90 A; B/D/F/H=12-20
PDB	3AX3; X-ray; 2.10 A; B/D/F/H=14-20
PDB	3AX5; X-ray; 2.20 A; B/D=14-20
PDBsum	1OM2; -; .
PDBsum	2V1S; -; .
PDBsum	2V1T; -; .
PDBsum	3AWR; -; .
PDBsum	3AX2; -; .
PDBsum	3AX3; -; .
PDBsum	3AX5; -; .
ProteinModelPortal	P11884; -; .
SMR	P11884; 26-519; .
IntAct	P11884; 2; .
STRING	P11884; -; .
PhosphoSite	P11884; -; .
World-2DPAGE	0004:P11884; -; .
PRIDE	P11884; -; .
GeneID	29539; -; .
KEGG	rno:29539; -; .
CTD	217; -; .
RGD	69219; Aldh2; .
eggNOG	maNOG06439; -; .
HOVERGEN	HBG000097; -; .
InParanoid	P11884; -; .
OrthoDB	EOG41ZF9P; -; .
PhylomeDB	P11884; -; .
NextBio	609531; -; .
ArrayExpress	P11884; -; .
Genevestigator	P11884; -; .
GermOnline	ENSRNOG00000001344; Rattus norvegicus; .
GO	GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell; .
GO	GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IDA:RGD; .
GO	GO:0042802; F:identical protein binding; IDA:RGD; .
GO	GO:0071398; P:cellular response to fatty acid; IEP:RGD; .
GO	GO:0032870; P:cellular response to hormone stimulus; IEP:RGD; .
GO	GO:0001889; P:liver development; IEP:RGD; .
GO	GO:0055093; P:response to hyperoxia; IEP:RGD; .
GO	GO:0032496; P:response to lipopolysaccharide; IEP:RGD; .
GO	GO:0035094; P:response to nicotine; IEP:RGD; .
GO	GO:0032570; P:response to progesterone stimulus; IEP:RGD; .
GO	GO:0033574; P:response to testosterone stimulus; IEP:RGD; .
InterPro	IPR016161; Ald_DH/histidinol_DH; .
InterPro	IPR016163; Ald_DH_C; .
InterPro	IPR016160; Ald_DH_CS; .
InterPro	IPR016162; Ald_DH_N; .
InterPro	IPR015590; Aldehyde_DH_dom; .
Gene3D	G3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1; .
Gene3D	G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1; .
KO	K00128; -; .
Pfam	PF00171; Aldedh; 1; .
SUPFAM	SSF53720; Aldehyde_DH/Histidinol_DH; 1; .
PROSITE	PS00070; ALDEHYDE_DEHYDR_CYS; 1; .
PROSITE	PS00687; ALDEHYDE_DEHYDR_GLU; 1; .

World-2DPAGE Repository (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server

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