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Searching in 'World-2DPAGE Repository [0022]' for entry matching: P11884




World-2DPAGE Repository (0022):  P11884

P11884


General information about the entry
View entry in simple text format
Entry nameALDH2_RAT
Primary accession numberP11884
integrated into World-2DPAGE Repository (0022) on May 7, 2010 (release 1)
2D Annotations were last modified onJune 22, 2011 (version 2)
General Annotations were last modified on November 24, 2011 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Aldehyde dehydrogenase, mitochondrial; EC=1.2.1.3; AltName: Full=ALDH class 2; AltName: Full=ALDH-E2; AltName: Full=ALDH1; Flags: Precursor;.
Gene nameName=Aldh2
Annotated speciesRattus [TaxID: 10114]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae.
References
[1]   2D-PAGE GEL CHARACTERIZATION
DOI=10.1002/pmic.201000593;
Burniston J.G., Kenyani J., Wastling J.M., Burant C.F., Qi N.R., Koch L.G., Britton S.L.
''Proteomic analysis reveals perturbed energy metabolism and elevated oxidative stress in hearts of rats with inborn low aerobic capacity''
Proteomics 11(16):3369-3379 (2011)
2D PAGE maps for identified proteins
How to interpret a protein

HCR_LCR_HEART {HCR LCR Cardiac Map}
Rattus
Tissue: Heart
HCR_LCR_HEART
  map experimental info 		 
HCR_LCR_HEART

MAP LOCATIONS:
pI=6.63; Mw=56966  [identification data]
pI=6.63; Mw=56966  [identification data]
pI=6.63; Mw=56966  [identification data]

IDENTIFICATION: SPOT 124: SeqCov=21.4%. Peptides MS=9/20. Mascot PMF Score=69 [1]
SPOT 244: SeqCov=27.7%. Peptides MS=14/20. Mascot PMF Score=126 [1]; SPOT 599: SeqCov=14.5%. Peptides MS=8/20. Mascot PMF Score=46 [1].
PEPTIDE EVIDENCE: SPOT 124: 397-GYFIQPTVFGDVK-409 (34) / 162-TIPIDGDFFSYTR-174 (88) / 327-TFVQEDVYDEFVER-340 (87) [1]
SPOT 599: 162-TIPIDGDFFSYTR-174 (98) / 327-TFVQEDVYDEFVER-340 (91) [1].
MAPPING (identification):
SPOT 124: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1];
SPOT 244: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1];
SPOT 599: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Copyright
Data from Dr. Jatin Burniston, Liverpool John Moores University, UK
Cross-references
UniProtKB/Swiss-ProtP11884; ALDH2_RAT.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_11
Entry nameALDH2_RAT
Primary accession numberP11884
Secondary accession number(s) Q6Q288 Q6Q289 Q6Q290 Q8K3V8 Q91ZD7
Sequence was last modified on October 1, 1989 (version 1)
Annotations were last modified on November 16, 2011 (version 115)
Name and origin of the protein
DescriptionRecName: Full=Aldehyde dehydrogenase, mitochondrial; EC=1.2.1.3; AltName: Full=ALDH class 2; AltName: Full=ALDH-E2; AltName: Full=ALDH1; Flags: Precursor;
Gene nameName=Aldh2
Encoded onName=Aldh2
Keywords3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Mitochondrion; NAD; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX14977; CAA33101.1; -; mRNA
EMBLBC062081; AAH62081.1; -; mRNA
EMBLM19030; AAA40719.1; -; mRNA
EMBLAY566467; AAS75813.1; -; mRNA
EMBLAY566468; AAS75814.1; -; mRNA
EMBLAY566469; AAS75815.1; -; mRNA
EMBLAF529165; AAM94394.2; -; mRNA
EMBLAY034137; AAK57732.1; -; Genomic_DNA
IPIIPI00197770; -; .
PIRS03564; S03564; .
RefSeqNP_115792.1; NM_032416.1; .
UniGeneRn.101781; -; .
PDB1OM2; NMR; -; B=12-20
PDB2V1S; X-ray; 2.05 A; H/I/J/K/L/M/N=12-20
PDB2V1T; X-ray; 1.92 A; C/D=12-22
PDB3AWR; X-ray; 2.00 A; C/D=12-20
PDB3AX2; X-ray; 1.90 A; B/D/F/H=12-20
PDB3AX3; X-ray; 2.10 A; B/D/F/H=14-20
PDB3AX5; X-ray; 2.20 A; B/D=14-20
PDBsum1OM2; -; .
PDBsum2V1S; -; .
PDBsum2V1T; -; .
PDBsum3AWR; -; .
PDBsum3AX2; -; .
PDBsum3AX3; -; .
PDBsum3AX5; -; .
ProteinModelPortalP11884; -; .
SMRP11884; 26-519; .
IntActP11884; 2; .
STRINGP11884; -; .
PhosphoSiteP11884; -; .
World-2DPAGE0004:P11884; -; .
PRIDEP11884; -; .
GeneID29539; -; .
KEGGrno:29539; -; .
CTD217; -; .
RGD69219; Aldh2; .
eggNOGmaNOG06439; -; .
HOVERGENHBG000097; -; .
InParanoidP11884; -; .
OrthoDBEOG41ZF9P; -; .
PhylomeDBP11884; -; .
NextBio609531; -; .
ArrayExpressP11884; -; .
GenevestigatorP11884; -; .
GermOnlineENSRNOG00000001344; Rattus norvegicus; .
GOGO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell; .
GOGO:0004029; F:aldehyde dehydrogenase (NAD) activity; IDA:RGD; .
GOGO:0042802; F:identical protein binding; IDA:RGD; .
GOGO:0071398; P:cellular response to fatty acid; IEP:RGD; .
GOGO:0032870; P:cellular response to hormone stimulus; IEP:RGD; .
GOGO:0001889; P:liver development; IEP:RGD; .
GOGO:0055093; P:response to hyperoxia; IEP:RGD; .
GOGO:0032496; P:response to lipopolysaccharide; IEP:RGD; .
GOGO:0035094; P:response to nicotine; IEP:RGD; .
GOGO:0032570; P:response to progesterone stimulus; IEP:RGD; .
GOGO:0033574; P:response to testosterone stimulus; IEP:RGD; .
InterProIPR016161; Ald_DH/histidinol_DH; .
InterProIPR016163; Ald_DH_C; .
InterProIPR016160; Ald_DH_CS; .
InterProIPR016162; Ald_DH_N; .
InterProIPR015590; Aldehyde_DH_dom; .
Gene3DG3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1; .
Gene3DG3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1; .
KOK00128; -; .
PfamPF00171; Aldedh; 1; .
SUPFAMSSF53720; Aldehyde_DH/Histidinol_DH; 1; .
PROSITEPS00070; ALDEHYDE_DEHYDR_CYS; 1; .
PROSITEPS00687; ALDEHYDE_DEHYDR_GLU; 1; .


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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server