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Searching in 'World-2DPAGE Repository [0022]' for entry matching: P17475

World-2DPAGE Repository (0022):  P17475


General information about the entry
View entry in simple text format
Entry nameA1AT_RAT
Primary accession numberP17475
integrated into World-2DPAGE Repository (0022) on May 7, 2010 (release 1)
2D Annotations were last modified onJune 22, 2011 (version 2)
General Annotations were last modified on November 24, 2011 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Alpha-1-antiproteinase; AltName: Full=Alpha-1-antitrypsin; AltName: Full=Alpha-1-proteinase inhibitor; AltName: Full=Serpin A1; Flags: Precursor;.
Gene nameName=Serpina1
Annotated speciesRattus [TaxID: 10114]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae.
Burniston J.G., Kenyani J., Wastling J.M., Burant C.F., Qi N.R., Koch L.G., Britton S.L.
''Proteomic analysis reveals perturbed energy metabolism and elevated oxidative stress in hearts of rats with inborn low aerobic capacity''
Proteomics 11(16):3369-3379 (2011)
2D PAGE maps for identified proteins
How to interpret a protein

Tissue: Heart
  map experimental info

pI=5.70; Mw=46278  [identification data]

IDENTIFICATION: SPOT 108: SeqCov=19.5%. Peptides MS=9/20. Mascot PMF Score=76 [1].
PEPTIDE EVIDENCE: SPOT 108: 319-TLLSSLGITR-328 (43) / 214-RPFNPEHTR-222 (32) / 44-ISSNLADFAFSLYR-57 (53) [1].
MAPPING (identification):
SPOT 108: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Data from Dr. Jatin Burniston, Liverpool John Moores University, UK
UniProtKB/Swiss-ProtP17475; A1AT_RAT.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_11
Entry nameA1AT_RAT
Primary accession numberP17475
Secondary accession number(s) Q6AYZ5
Sequence was last modified on February 1, 1991 (version 2)
Annotations were last modified on November 16, 2011 (version 99)
Name and origin of the protein
DescriptionRecName: Full=Alpha-1-antiproteinase; AltName: Full=Alpha-1-antitrypsin; AltName: Full=Alpha-1-proteinase inhibitor; AltName: Full=Serpin A1; Flags: Precursor;
Gene nameName=Serpina1
Encoded onName=Serpina1
KeywordsAcute phase; Complete proteome; Direct protein sequencing; Glycoprotein; Protease inhibitor; Reference proteome; Secreted; Serine protease inhibitor; Signal.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLD00675; BAA00579.1; -; mRNA
EMBLBC078824; AAH78824.1; -; mRNA
EMBLM32247; AAA40788.1; -; mRNA
EMBLX16273; CAA34349.1; -; mRNA
IPIIPI00324019; -; .
PIRA33892; ITRT; .
RefSeqNP_071964.2; NM_022519.2; .
UniGeneRn.1419; -; .
ProteinModelPortalP17475; -; .
SMRP17475; 39-411; .
STRINGP17475; -; .
MEROPSI04.001; -; .
PhosphoSiteP17475; -; .
PRIDEP17475; -; .
EnsemblENSRNOT00000012577; ENSRNOP00000012577; ENSRNOG00000032669; .
GeneID24648; -; .
KEGGrno:24648; -; .
UCSCNM_022519; rat; .
CTD5265; -; .
RGD3326; Serpina1; .
eggNOGroNOG13393; -; .
GeneTreeENSGT00560000076583; -; .
HOVERGENHBG005957; -; .
InParanoidP17475; -; .
OrthoDBEOG4FR0S4; -; .
NextBio603964; -; .
ArrayExpressP17475; -; .
GenevestigatorP17475; -; .
GermOnlineENSRNOG00000032669; Rattus norvegicus; .
GOGO:0005615; C:extracellular space; IDA:RGD; .
GOGO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:RefGenome; .
GOGO:0006953; P:acute-phase response; IEA:UniProtKB-KW; .
GOGO:0030162; P:regulation of proteolysis; IBA:RefGenome; .
GOGO:0046687; P:response to chromate; IDA:RGD; .
GOGO:0034097; P:response to cytokine stimulus; IEP:RGD; .
GOGO:0032355; P:response to estradiol stimulus; IEP:RGD; .
GOGO:0001666; P:response to hypoxia; IEP:RGD; .
GOGO:0010288; P:response to lead ion; IDA:RGD; .
GOGO:0032496; P:response to lipopolysaccharide; IEP:RGD; .
GOGO:0033986; P:response to methanol; IDA:RGD; .
GOGO:0014070; P:response to organic cyclic compound; IEP:RGD; .
GOGO:0034014; P:response to triglyceride; IEP:RGD; .
InterProIPR000215; Protease_inhib_I4_serpin; .
InterProIPR023795; Protease_inhib_I4_serpin_CS; .
InterProIPR023796; Sepin_dom; .
KOK03984; -; .
PANTHERPTHR11461; Prot_inh_serpin; 1; .
PfamPF00079; Serpin; 1; .
SMARTSM00093; SERPIN; 1; .
SUPFAMSSF56574; Prot_inh_serpin; 1; .

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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server