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Searching in 'World-2DPAGE Repository [0027]' for entry matching: P26040

World-2DPAGE Repository (0027):  P26040


General information about the entry
View entry in simple text format
Entry nameEZRI_MOUSE
Primary accession numberP26040
integrated into World-2DPAGE Repository (0027) on September 30, 2010 (release 1)
2D Annotations were last modified onJune 21, 2011 (version 2)
General Annotations were last modified on November 23, 2011 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Ezrin; AltName: Full=Cytovillin; AltName: Full=Villin-2; AltName: Full=p81;.
Gene nameName=Ezr
Annotated speciesMus musculus (Mouse) [TaxID: 10090]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus.
Blutke A., Block C., Berendt F., Herbach N., Kemter E., Amann K., Frolich T., Arnold G.J., Wanke R.
''Differential glomerular proteome analysis of two murine nephropathy models at onset of albuminuria''
Proteomics - Clinical Applications 5(6):375-381 (2011)
2D PAGE maps for identified proteins
How to interpret a protein

GH_4-7 {glomerular protein lysates of a GH-tg animal}
Mus musculus (Mouse)
  map experimental info

pI=6.10; Mw=76000  [identification data]
pI=6.20; Mw=76000  [identification data]

SPOT 4: Avg ratio GH-tg vs. control=-1.59 (p-value=0.0093) [1];
SPOT 5: Avg ratio GH-tg vs. control=-1.59 (p-value=0.0031) [1].

IDENTIFICATION: SPOT 4: SeqCov=39%. Mascot protein score=408 [1]
SPOT 5: SeqCov=57%. Mascot protein score=716 [1].
MAPPING (identification):
SPOT 4: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1];
SPOT 5: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Data from Dr. Andreas Blutke, Institute of Veterinary Pathology, University Munich, Germany
UniProtKB/Swiss-ProtP26040; EZRI_MOUSE.
World-2DPAGE RepositoryP26040; EZRI_MOUSE.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_11
Entry nameEZRI_MOUSE
Primary accession numberP26040
Secondary accession number(s) Q80ZT8 Q9DCI1
Sequence was last modified on January 23, 2007 (version 3)
Annotations were last modified on November 16, 2011 (version 110)
Name and origin of the protein
DescriptionRecName: Full=Ezrin; AltName: Full=Cytovillin; AltName: Full=Villin-2; AltName: Full=p81;
Gene nameName=Ezr
Encoded onName=Ezr; Synonyms=Vil2
KeywordsAcetylation; Cell membrane; Cell projection; Cell shape; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Phosphoprotein; Reference proteome.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLX60671; CAA43086.1; -; mRNA
EMBLAK002766; BAB22341.1; -; mRNA
EMBLBC048181; AAH48181.2; -; mRNA
IPIIPI00330862; -; .
PIRB41129; B41129; .
RefSeqNP_033536.2; NM_009510.2; .
UniGeneMm.277812; -; .
ProteinModelPortalP26040; -; .
SMRP26040; 1-586; .
IntActP26040; 3; .
MINTMINT-1708640; -; .
STRINGP26040; -; .
TCDB8.A.25.1.1; ezrin/radixin/moesin (Ezrin) family; .
PhosphoSiteP26040; -; .
PRIDEP26040; -; .
EnsemblENSMUST00000064234; ENSMUSP00000063734; ENSMUSG00000052397; .
GeneID22350; -; .
KEGGmmu:22350; -; .
CTD7430; -; .
MGIMGI:98931; Ezr; .
eggNOGroNOG13879; -; .
HOGENOMHBG446392; -; .
HOVERGENHBG002185; -; .
InParanoidP26040; -; .
OrthoDBEOG4C5CJJ; -; .
PhylomeDBP26040; -; .
NextBio457682; -; .
ArrayExpressP26040; -; .
BgeeP26040; -; .
CleanExMM_EZR; -; .
GenevestigatorP26040; -; .
GermOnlineENSMUSG00000052397; Mus musculus; .
GOGO:0005884; C:actin filament; ISS:UniProtKB; .
GOGO:0016324; C:apical plasma membrane; IDA:MGI; .
GOGO:0005938; C:cell cortex; IEA:UniProtKB-SubCell; .
GOGO:0019898; C:extrinsic to membrane; ISS:UniProtKB; .
GOGO:0005932; C:microtubule basal body; IDA:MGI; .
GOGO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell; .
GOGO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell; .
GOGO:0001931; C:uropod; IDA:MGI; .
GOGO:0051015; F:actin filament binding; ISS:UniProtKB; .
GOGO:0050839; F:cell adhesion molecule binding; ISS:BHF-UCL; .
GOGO:0051017; P:actin filament bundle assembly; ISS:UniProtKB; .
GOGO:0035088; P:establishment or maintenance of apical/basal cell polarity; IMP:MGI; .
GOGO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW; .
InterProIPR019749; Band_41_domain; .
InterProIPR019750; Band_41_fam; .
InterProIPR011174; ERM; .
InterProIPR011259; ERM_C; .
InterProIPR000798; Ez/rad/moesin; .
InterProIPR014352; FERM/acyl-CoA-bd_prot_3-hlx; .
InterProIPR019748; FERM_central; .
InterProIPR019747; FERM_CS; .
InterProIPR000299; FERM_domain; .
InterProIPR018979; FERM_N; .
InterProIPR018980; FERM_PH-like_C; .
InterProIPR008954; Moesin; .
InterProIPR011993; PH_type; .
Gene3DG3DSA:; ACBP; 1; .
Gene3DG3DSA:; PH_type; 1; .
KOK08007; -; .
PfamPF00769; ERM; 1; .
PfamPF09380; FERM_C; 1; .
PfamPF00373; FERM_M; 1; .
PfamPF09379; FERM_N; 1; .
PIRSFPIRSF002305; ERM; 1; .
PRINTSPR00935; BAND41; .
SMARTSM00295; B41; 1; .
SUPFAMSSF47031; FERM_3-hlx; 1; .
SUPFAMSSF48678; Moesin; 1; .
PROSITEPS00660; FERM_1; 1; .
PROSITEPS00661; FERM_2; 1; .
PROSITEPS50057; FERM_3; 1; .

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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server