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Searching in 'World-2DPAGE Repository [0030]' for entry matching: P35426

World-2DPAGE Repository (0030):  P35426


General information about the entry
View entry in simple text format
Entry nameCDK4_RAT
Primary accession numberP35426
integrated into World-2DPAGE Repository (0030) on November 9, 2010 (release 1)
2D Annotations were last modified onJune 21, 2011 (version 2)
General Annotations were last modified on November 23, 2011 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Cyclin-dependent kinase 4; EC=; AltName: Full=Cell division protein kinase 4; AltName: Full=PSK-J3;.
Gene nameName=Cdk4
Annotated speciesRattus norvegicus (Rat) [TaxID: 10116]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
D'Hertog W., Maris M., Thorrez L., Waelkens E., Overbergh L., Mathieu C.
''Two-dimensional gel proteome reference map of INS-1E cells''
Proteomics 11(7):1365-1369 (2011)
2D PAGE maps for identified proteins
How to interpret a protein

RAT_INS1E_4-7 {INS-1E cell line, a model rat cell line for pancreatic beta cells, PH4-7}
Rattus norvegicus (Rat)
  map experimental info

pI=6.33; Mw=35454  [identification data]

IDENTIFICATION: SPOT 1850: Mascot protein score=157. Number of peptides=7 [1].
MAPPING (identification):
SPOT 1850: Tandem mass spectrometry [1].

Data from Dr. Wannes D'Hertog, Catholic University Leuven, Belgium
UniProtKB/Swiss-ProtP35426; CDK4_RAT.
World-2DPAGE RepositoryP35426; CDK4_RAT.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_11
Entry nameCDK4_RAT
Primary accession numberP35426
Sequence was last modified on June 1, 1994 (version 1)
Annotations were last modified on November 16, 2011 (version 98)
Name and origin of the protein
DescriptionRecName: Full=Cyclin-dependent kinase 4; EC=; AltName: Full=Cell division protein kinase 4; AltName: Full=PSK-J3;
Gene nameName=Cdk4
Encoded onName=Cdk4
KeywordsAcetylation; ATP-binding; Cell cycle; Cell division; Complete proteome; Cytoplasm; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome; Serine/threonine-protein kinase; Transferase.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLL11007; AAA40903.1; -; mRNA
EMBLBC070956; AAH70956.1; -; mRNA
IPIIPI00198608; -; .
PIRJN0460; JN0460; .
RefSeqNP_446045.1; NM_053593.2; .
UniGeneRn.6115; -; .
ProteinModelPortalP35426; -; .
SMRP35426; 2-299; .
STRINGP35426; -; .
PRIDEP35426; -; .
GeneID94201; -; .
KEGGrno:94201; -; .
CTD1019; -; .
RGD621120; Cdk4; .
eggNOGmaNOG14658; -; .
GeneTreeENSGT00600000084298; -; .
HOVERGENHBG014652; -; .
InParanoidP35426; -; .
OrthoDBEOG4NGGN6; -; .
PhylomeDBP35426; -; .
BRENDA2.7.11.22; 5301; .
NextBio617871; -; .
ArrayExpressP35426; -; .
GenevestigatorP35426; -; .
GermOnlineENSRNOG00000025602; Rattus norvegicus; .
GOGO:0016020; C:membrane; IEA:UniProtKB-SubCell; .
GOGO:0048471; C:perinuclear region of cytoplasm; IDA:RGD; .
GOGO:0005524; F:ATP binding; IEA:UniProtKB-KW; .
GOGO:0030332; F:cyclin binding; IPI:RGD; .
GOGO:0004693; F:cyclin-dependent protein kinase activity; IDA:RGD; .
GOGO:0051301; P:cell division; IEA:UniProtKB-KW; .
GOGO:0007623; P:circadian rhythm; IEP:RGD; .
GOGO:0031100; P:organ regeneration; IEP:RGD; .
GOGO:0043065; P:positive regulation of apoptosis; IMP:RGD; .
GOGO:0045787; P:positive regulation of cell cycle; TAS:RGD; .
GOGO:0008284; P:positive regulation of cell proliferation; IMP:RGD; .
GOGO:0045793; P:positive regulation of cell size; IMP:RGD; .
GOGO:0045727; P:positive regulation of translation; IMP:RGD; .
GOGO:0055093; P:response to hyperoxia; IEP:RGD; .
GOGO:0010288; P:response to lead ion; IMP:RGD; .
GOGO:0033574; P:response to testosterone stimulus; IDA:RGD; .
GOGO:0009636; P:response to toxin; IEP:RGD; .
InterProIPR011009; Kinase-like_dom; .
InterProIPR000719; Prot_kinase_cat_dom; .
InterProIPR017441; Protein_kinase_ATP_BS; .
InterProIPR017442; Se/Thr_kinase-like_dom; .
InterProIPR008271; Ser/Thr_kinase_AS; .
InterProIPR002290; Ser/Thr_kinase_dom; .
KOK02089; -; .
PfamPF00069; Pkinase; 1; .
SMARTSM00220; S_TKc; 1; .
SUPFAMSSF56112; Kinase_like; 1; .

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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server