World-2DPAGE Repository
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World-2DPAGE Repository
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SWISS-2DPAGE
World-2DPAGE Portal
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Searching in 'World-2DPAGE Repository [0004]' for entry
matching:
P50554
World-2DPAGE Repository
(0004):
P50554
P50554
General information about the entry
View entry in simple text format
Entry name
GABT_RAT
Primary accession number
P50554
integrated into World-2DPAGE Repository (0004) on
October 13, 2008 (release 1)
2D Annotations were last modified on
May 18, 2011 (version 2)
General Annotations were last modified on
December 22, 2011 (version 2)
Name and origin of the protein
Description
RecName: Full=4-aminobutyrate aminotransferase, mitochondrial; EC=2.6.1.19; AltName: Full=(S)-3-amino-2-methylpropionate transaminase; EC=2.6.1.22; AltName: Full=GABA aminotransferase; Short=GABA-AT; AltName: Full=Gamma-amino-N-butyrate transaminase; Short=GABA transaminase; Short=GABA-T; AltName: Full=L-AIBAT; Contains: RecName: Full=4-aminobutyrate aminotransferase, brain isoform; Contains: RecName: Full=4-aminobutyrate aminotransferase, liver isoform; Flags: Precursor;.
Gene name
Name=Abat
Synonyms=Gabat
Annotated species
Rattus norvegicus (Rat) [TaxID:
10116
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
References
[1]
MAPPING ON GEL
PubMed=19343716; DOI=
10.1002/pmic.200800664
; [
NCBI
,
EBI
,
Israel
,
Japan
]
Maurya D.K., Sundaram C.S., Bhargava P.
''Proteome profile of the mature rat olfactory bulb''
Proteomics 9(1):2593-2599 (2009)
2D PAGE maps for identified proteins
How to interpret a protein
OB21DSUB
{2-DE gel for Olfactory bulb proteome}
Rattus norvegicus (Rat)
Tissue: Olfactory bulb
map experimental info
OB21DSUB
MAP LOCATIONS:
SPOT 360
:
pI=6.92; Mw=49000
[identification data]
MAPPING (identification):
SPOT
360
:
Peptide mass fingerprinting
[
1
];
Tandem mass spectrometry
[
1
].
Copyright
Data from Dr. Purnima Bhargava, Centre for Cellular and Molecular Biology, India
Cross-references
UniProtKB/Swiss-Prot
P50554; GABT_RAT.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
2011_12
Entry name
GABT_RAT
Primary accession number
P50554
Secondary accession number(s)
O70539 Q66HM1
Sequence was last modified on
January 9, 2007 (version 3)
Annotations were last modified on
November 16, 2011 (version 99)
Name and origin of the protein
Description
RecName: Full=4-aminobutyrate aminotransferase, mitochondrial; EC=2.6.1.19; AltName: Full=(S)-3-amino-2-methylpropionate transaminase; EC=2.6.1.22; AltName: Full=GABA aminotransferase; Short=GABA-AT; AltName: Full=Gamma-amino-N-butyrate transaminase; Short=GABA transaminase; Short=GABA-T; AltName: Full=L-AIBAT; Contains: RecName: Full=4-aminobutyrate aminotransferase, brain isoform; Contains: RecName: Full=4-aminobutyrate aminotransferase, liver isoform; Flags: Precursor;
Gene name
Name=Abat
Synonyms=Gabat
Encoded on
Name=Abat; Synonyms=Gabat
Keywords
Acetylation
;
Aminotransferase
;
Complete proteome
;
Direct protein sequencing
;
Disulfide bond
;
Mitochondrion
;
Neurotransmitter degradation
;
Pyridoxal phosphate
;
Reference proteome
;
Transferase
;
Transit peptide
.
Copyright
Copyrighted by the UniProt Consortium, see
https://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
U29701; AAA70415.1
; -; mRNA
EMBL
D87839; BAA25570.1
; -; mRNA
EMBL
BC081787; AAH81787.1
; -; mRNA
IPI
IPI00199426; -
; .
PIR
I56502; I56502
; .
RefSeq
NP_112265.1; NM_031003.1
; .
UniGene
Rn.10090; -
; .
ProteinModelPortal
P50554; -
; .
SMR
P50554; 39-499
; .
STRING
P50554; -
; .
PhosphoSite
P50554; -
; .
World-2DPAGE
0004:P50554; -
; .
PRIDE
P50554; -
; .
Ensembl
ENSRNOT00000003633; ENSRNOP00000003633
; ENSRNOG00000002636; .
GeneID
81632; -
; .
KEGG
rno:81632; -
; .
NMPDR
fig|10116.3.peg.4435; -
; .
UCSC
NM_031003; rat
; .
CTD
18; -
; .
RGD
620948; Abat
; .
eggNOG
roNOG08236; -
; .
GeneTree
ENSGT00550000074885; -
; .
HOVERGEN
HBG000634; -
; .
InParanoid
P50554; -
; .
OMA
ATGKFWA; -
; .
OrthoDB
EOG441QB6; -
; .
PhylomeDB
P50554; -
; .
NextBio
615107; -
; .
ArrayExpress
P50554; -
; .
Genevestigator
P50554; -
; .
GermOnline
ENSRNOG00000002636; Rattus norvegicus
; .
GO
GO:0032144; C:4-aminobutyrate transaminase complex
; ISS:UniProtKB; .
GO
GO:0005759; C:mitochondrial matrix
; IEA:UniProtKB-SubCell; .
GO
GO:0019717; C:synaptosome
; IDA:RGD; .
GO
GO:0047298; F:(S)-3-amino-2-methylpropionate transaminase activity
; IEA:EC; .
GO
GO:0003867; F:4-aminobutyrate transaminase activity
; IDA:RGD; .
GO
GO:0042803; F:protein homodimerization activity
; ISS:UniProtKB; .
GO
GO:0030170; F:pyridoxal phosphate binding
; ISS:UniProtKB; .
GO
GO:0032145; F:succinate-semialdehyde dehydrogenase binding
; ISS:UniProtKB; .
GO
GO:0048148; P:behavioral response to cocaine
; ISS:UniProtKB; .
GO
GO:0007620; P:copulation
; IMP:RGD; .
GO
GO:0009450; P:gamma-aminobutyric acid catabolic process
; IC:UniProtKB; .
GO
GO:0007626; P:locomotory behavior
; IMP:RGD; .
GO
GO:0045776; P:negative regulation of blood pressure
; IMP:RGD; .
GO
GO:0042135; P:neurotransmitter catabolic process
; IC:UniProtKB; .
GO
GO:0042493; P:response to drug
; IDA:RGD; .
GO
GO:0045471; P:response to ethanol
; IDA:RGD; .
GO
GO:0001666; P:response to hypoxia
; IMP:RGD; .
GO
GO:0010039; P:response to iron ion
; IDA:RGD; .
GO
GO:0035094; P:response to nicotine
; IMP:RGD; .
InterPro
IPR004631; 4NH2But_aminotransferase_euk
; .
InterPro
IPR005814; Aminotrans_3
; .
InterPro
IPR015424; PyrdxlP-dep_Trfase_major_dom
; .
InterPro
IPR015421; PyrdxlP-dep_Trfase_major_sub1
; .
InterPro
IPR015422; PyrdxlP-dep_Trfase_major_sub2
; .
Gene3D
G3DSA:3.40.640.10; PyrdxlP-dep_Trfase_major_sub1
; 1; .
Gene3D
G3DSA:3.90.1150.10; PyrdxlP-dep_Trfase_major_sub2
; 2; .
KO
K13524; -
; .
PANTHER
PTHR11986; Aminotrans_3
; 1; .
PANTHER
PTHR11986:SF6; GABAtrns_euk
; 1; .
Pfam
PF00202; Aminotran_3
; 1; .
SUPFAM
SSF53383; PyrdxlP-dep_Trfase_major
; 1; .
TIGRFAMs
TIGR00699; GABAtrns_euk
; 1; .
PROSITE
PS00600; AA_TRANSFER_CLASS_3
; 1; .
World-2DPAGE Repository (search AC)
Database constructed and maintained by
SIB
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
Expasy web server