World-2DPAGE Repository

RecName: Full=4-aminobutyrate aminotransferase, mitochondrial; EC=2.6.1.19; AltName: Full=(S)-3-amino-2-methylpropionate transaminase; EC=2.6.1.22; AltName: Full=GABA aminotransferase; Short=GABA-AT; AltName: Full=Gamma-amino-N-butyrate transaminase; Short=GABA transaminase; Short=GABA-T; AltName: Full=L-AIBAT; Contains: RecName: Full=4-aminobutyrate aminotransferase, brain isoform; Contains: RecName: Full=4-aminobutyrate aminotransferase, liver isoform; Flags: Precursor;.

Gene name

Name=Abat
Synonyms=Gabat

Annotated species

Rattus norvegicus (Rat) [TaxID: 10116]

Taxonomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.

References

[1]	MAPPING ON GEL PubMed=19343716; DOI=10.1002/pmic.200800664; [NCBI, EBI, Israel, Japan] Maurya D.K., Sundaram C.S., Bhargava P. ''Proteome profile of the mature rat olfactory bulb'' Proteomics 9(1):2593-2599 (2009)

2D PAGE maps for identified proteins

How to interpret a protein

OB21DSUB {2-DE gel for Olfactory bulb proteome}
Rattus norvegicus (Rat)
Tissue: Olfactory bulb

map experimental info

OB21DSUB

MAP LOCATIONS:

SPOT 360:

pI=6.92; Mw=49000

[identification data]

MAPPING (identification):

SPOT 360: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Copyright

Data from Dr. Purnima Bhargava, Centre for Cellular and Molecular Biology, India

Cross-references

UniProtKB/Swiss-Prot

P50554; GABT_RAT.

2D PAGE maps for identified proteins
How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_12
Entry name	GABT_RAT
Primary accession number	P50554
Secondary accession number(s)	O70539 Q66HM1
Sequence was last modified on	January 9, 2007 (version 3)
Annotations were last modified on	November 16, 2011 (version 99)
Name and origin of the protein
Description	RecName: Full=4-aminobutyrate aminotransferase, mitochondrial; EC=2.6.1.19; AltName: Full=(S)-3-amino-2-methylpropionate transaminase; EC=2.6.1.22; AltName: Full=GABA aminotransferase; Short=GABA-AT; AltName: Full=Gamma-amino-N-butyrate transaminase; Short=GABA transaminase; Short=GABA-T; AltName: Full=L-AIBAT; Contains: RecName: Full=4-aminobutyrate aminotransferase, brain isoform; Contains: RecName: Full=4-aminobutyrate aminotransferase, liver isoform; Flags: Precursor;
Gene name	Name=Abat Synonyms=Gabat
Encoded on	Name=Abat; Synonyms=Gabat
Keywords	Acetylation; Aminotransferase; Complete proteome; Direct protein sequencing; Disulfide bond; Mitochondrion; Neurotransmitter degradation; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL	U29701; AAA70415.1; -; mRNA
EMBL	D87839; BAA25570.1; -; mRNA
EMBL	BC081787; AAH81787.1; -; mRNA
IPI	IPI00199426; -; .
PIR	I56502; I56502; .
RefSeq	NP_112265.1; NM_031003.1; .
UniGene	Rn.10090; -; .
ProteinModelPortal	P50554; -; .
SMR	P50554; 39-499; .
STRING	P50554; -; .
PhosphoSite	P50554; -; .
World-2DPAGE	0004:P50554; -; .
PRIDE	P50554; -; .
Ensembl	ENSRNOT00000003633; ENSRNOP00000003633; ENSRNOG00000002636; .
GeneID	81632; -; .
KEGG	rno:81632; -; .
NMPDR	fig\|10116.3.peg.4435; -; .
UCSC	NM_031003; rat; .
CTD	18; -; .
RGD	620948; Abat; .
eggNOG	roNOG08236; -; .
GeneTree	ENSGT00550000074885; -; .
HOVERGEN	HBG000634; -; .
InParanoid	P50554; -; .
OMA	ATGKFWA; -; .
OrthoDB	EOG441QB6; -; .
PhylomeDB	P50554; -; .
NextBio	615107; -; .
ArrayExpress	P50554; -; .
Genevestigator	P50554; -; .
GermOnline	ENSRNOG00000002636; Rattus norvegicus; .
GO	GO:0032144; C:4-aminobutyrate transaminase complex; ISS:UniProtKB; .
GO	GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell; .
GO	GO:0019717; C:synaptosome; IDA:RGD; .
GO	GO:0047298; F:(S)-3-amino-2-methylpropionate transaminase activity; IEA:EC; .
GO	GO:0003867; F:4-aminobutyrate transaminase activity; IDA:RGD; .
GO	GO:0042803; F:protein homodimerization activity; ISS:UniProtKB; .
GO	GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB; .
GO	GO:0032145; F:succinate-semialdehyde dehydrogenase binding; ISS:UniProtKB; .
GO	GO:0048148; P:behavioral response to cocaine; ISS:UniProtKB; .
GO	GO:0007620; P:copulation; IMP:RGD; .
GO	GO:0009450; P:gamma-aminobutyric acid catabolic process; IC:UniProtKB; .
GO	GO:0007626; P:locomotory behavior; IMP:RGD; .
GO	GO:0045776; P:negative regulation of blood pressure; IMP:RGD; .
GO	GO:0042135; P:neurotransmitter catabolic process; IC:UniProtKB; .
GO	GO:0042493; P:response to drug; IDA:RGD; .
GO	GO:0045471; P:response to ethanol; IDA:RGD; .
GO	GO:0001666; P:response to hypoxia; IMP:RGD; .
GO	GO:0010039; P:response to iron ion; IDA:RGD; .
GO	GO:0035094; P:response to nicotine; IMP:RGD; .
InterPro	IPR004631; 4NH2But_aminotransferase_euk; .
InterPro	IPR005814; Aminotrans_3; .
InterPro	IPR015424; PyrdxlP-dep_Trfase_major_dom; .
InterPro	IPR015421; PyrdxlP-dep_Trfase_major_sub1; .
InterPro	IPR015422; PyrdxlP-dep_Trfase_major_sub2; .
Gene3D	G3DSA:3.40.640.10; PyrdxlP-dep_Trfase_major_sub1; 1; .
Gene3D	G3DSA:3.90.1150.10; PyrdxlP-dep_Trfase_major_sub2; 2; .
KO	K13524; -; .
PANTHER	PTHR11986; Aminotrans_3; 1; .
PANTHER	PTHR11986:SF6; GABAtrns_euk; 1; .
Pfam	PF00202; Aminotran_3; 1; .
SUPFAM	SSF53383; PyrdxlP-dep_Trfase_major; 1; .
TIGRFAMs	TIGR00699; GABAtrns_euk; 1; .
PROSITE	PS00600; AA_TRANSFER_CLASS_3; 1; .

World-2DPAGE Repository (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server

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