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Searching in 'World-2DPAGE Repository [0019]' for entry matching: P50554




World-2DPAGE Repository (0019):  P50554


P50554


General information about the entry
View entry in simple text format
Entry nameGABT_RAT
Primary accession numberP50554
integrated into World-2DPAGE Repository (0019) on December 9, 2009 (release 1)
2D Annotations were last modified onMay 30, 2011 (version 2)
General Annotations were last modified on January 13, 2012 (version 2)
Name and origin of the protein
DescriptionRecName: Full=4-aminobutyrate aminotransferase, mitochondrial; EC=2.6.1.19; AltName: Full=(S)-3-amino-2-methylpropionate transaminase; EC=2.6.1.22; AltName: Full=GABA aminotransferase; Short=GABA-AT; AltName: Full=Gamma-amino-N-butyrate transaminase; Short=GABA transaminase; Short=GABA-T; AltName: Full=L-AIBAT; Contains: RecName: Full=4-aminobutyrate aminotransferase, brain isoform; Contains: RecName: Full=4-aminobutyrate aminotransferase, liver isoform; Flags: Precursor;.
Gene nameName=Abat
Synonyms=Gabat
Annotated speciesRattus norvegicus (Rat) [TaxID: 10116]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
References
[1]   2D-PAGE GEL CHARACTERIZATION
DOI=10.1111/j.1471-4159.2010.06719.x;
VanGuilder H.D., Yan H., Farley J.A., Sonntag W.E., Freeman W.M.
''Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome''
J of Neurochemistry 113(6):1577-1588 (2010)
2D PAGE maps for identified proteins
How to interpret a protein

HIPP_SYNAP {Rat hippocampal synaptoproteome}
Rattus norvegicus (Rat)
Tissue: Hippocampus
HIPP_SYNAP
  map experimental info
 
HIPP_SYNAP

MAP LOCATIONS:
pI=8.15; Mw=57160  [identification data]
pI=8.15; Mw=57160  [identification data]
pI=8.15; Mw=57160  [identification data]

IDENTIFICATION: SPOT 447: Peptides number=9. SeqCov=26.4%. MOWSE score=2.59E+10 [1]
SPOT 1163: Peptides number=8. SeqCov=23.6%. MOWSE score=4.36E+11 [1]; SPOT 1164: Peptides number=6. SeqCov=18.2%. MOWSE score=2.06E+6 [1].
MAPPING (identification):
SPOT 447: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1];
SPOT 1163: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1];
SPOT 1164: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Copyright
Data from Dr. Willard Freeman, Penn State College of Medicine, USA
Cross-references
UniProtKB/Swiss-ProtP50554; GABT_RAT.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_12
Entry nameGABT_RAT
Primary accession numberP50554
Secondary accession number(s) O70539 Q66HM1
Sequence was last modified on January 9, 2007 (version 3)
Annotations were last modified on November 16, 2011 (version 99)
Name and origin of the protein
DescriptionRecName: Full=4-aminobutyrate aminotransferase, mitochondrial; EC=2.6.1.19; AltName: Full=(S)-3-amino-2-methylpropionate transaminase; EC=2.6.1.22; AltName: Full=GABA aminotransferase; Short=GABA-AT; AltName: Full=Gamma-amino-N-butyrate transaminase; Short=GABA transaminase; Short=GABA-T; AltName: Full=L-AIBAT; Contains: RecName: Full=4-aminobutyrate aminotransferase, brain isoform; Contains: RecName: Full=4-aminobutyrate aminotransferase, liver isoform; Flags: Precursor;
Gene nameName=Abat
Synonyms=Gabat
Encoded onName=Abat; Synonyms=Gabat
KeywordsAcetylation; Aminotransferase; Complete proteome; Direct protein sequencing; Disulfide bond; Mitochondrion; Neurotransmitter degradation; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLU29701; AAA70415.1; -; mRNA
EMBLD87839; BAA25570.1; -; mRNA
EMBLBC081787; AAH81787.1; -; mRNA
IPIIPI00199426; -; .
PIRI56502; I56502; .
RefSeqNP_112265.1; NM_031003.1; .
UniGeneRn.10090; -; .
ProteinModelPortalP50554; -; .
SMRP50554; 39-499; .
STRINGP50554; -; .
PhosphoSiteP50554; -; .
World-2DPAGE0004:P50554; -; .
PRIDEP50554; -; .
EnsemblENSRNOT00000003633; ENSRNOP00000003633; ENSRNOG00000002636; .
GeneID81632; -; .
KEGGrno:81632; -; .
NMPDRfig|10116.3.peg.4435; -; .
UCSCNM_031003; rat; .
CTD18; -; .
RGD620948; Abat; .
eggNOGroNOG08236; -; .
GeneTreeENSGT00550000074885; -; .
HOVERGENHBG000634; -; .
InParanoidP50554; -; .
OMAATGKFWA; -; .
OrthoDBEOG441QB6; -; .
PhylomeDBP50554; -; .
NextBio615107; -; .
ArrayExpressP50554; -; .
GenevestigatorP50554; -; .
GermOnlineENSRNOG00000002636; Rattus norvegicus; .
GOGO:0032144; C:4-aminobutyrate transaminase complex; ISS:UniProtKB; .
GOGO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell; .
GOGO:0019717; C:synaptosome; IDA:RGD; .
GOGO:0047298; F:(S)-3-amino-2-methylpropionate transaminase activity; IEA:EC; .
GOGO:0003867; F:4-aminobutyrate transaminase activity; IDA:RGD; .
GOGO:0042803; F:protein homodimerization activity; ISS:UniProtKB; .
GOGO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB; .
GOGO:0032145; F:succinate-semialdehyde dehydrogenase binding; ISS:UniProtKB; .
GOGO:0048148; P:behavioral response to cocaine; ISS:UniProtKB; .
GOGO:0007620; P:copulation; IMP:RGD; .
GOGO:0009450; P:gamma-aminobutyric acid catabolic process; IC:UniProtKB; .
GOGO:0007626; P:locomotory behavior; IMP:RGD; .
GOGO:0045776; P:negative regulation of blood pressure; IMP:RGD; .
GOGO:0042135; P:neurotransmitter catabolic process; IC:UniProtKB; .
GOGO:0042493; P:response to drug; IDA:RGD; .
GOGO:0045471; P:response to ethanol; IDA:RGD; .
GOGO:0001666; P:response to hypoxia; IMP:RGD; .
GOGO:0010039; P:response to iron ion; IDA:RGD; .
GOGO:0035094; P:response to nicotine; IMP:RGD; .
InterProIPR004631; 4NH2But_aminotransferase_euk; .
InterProIPR005814; Aminotrans_3; .
InterProIPR015424; PyrdxlP-dep_Trfase_major_dom; .
InterProIPR015421; PyrdxlP-dep_Trfase_major_sub1; .
InterProIPR015422; PyrdxlP-dep_Trfase_major_sub2; .
Gene3DG3DSA:3.40.640.10; PyrdxlP-dep_Trfase_major_sub1; 1; .
Gene3DG3DSA:3.90.1150.10; PyrdxlP-dep_Trfase_major_sub2; 2; .
KOK13524; -; .
PANTHERPTHR11986; Aminotrans_3; 1; .
PANTHERPTHR11986:SF6; GABAtrns_euk; 1; .
PfamPF00202; Aminotran_3; 1; .
SUPFAMSSF53383; PyrdxlP-dep_Trfase_major; 1; .
TIGRFAMsTIGR00699; GABAtrns_euk; 1; .
PROSITEPS00600; AA_TRANSFER_CLASS_3; 1; .



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