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Searching in 'World-2DPAGE Repository [0022]' for entry matching: P51583 World-2DPAGE Repository (0022):  P51583 P51583 General information about the entry View entry in simple text format Entry name PUR6_RAT Primary accession number P51583 integrated into World-2DPAGE Repository (0022) on  May 7, 2010 (release 1) 2D Annotations were last modified on June 22, 2011 (version 2) General Annotations were last modified on  November 24, 2011 (version 2) Name and origin of the protein Description RecName: Full=Multifunctional protein ADE2; Includes: RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase; EC=6.3.2.6; AltName: Full=SAICAR synthetase; Includes: RecName: Full=Phosphoribosylaminoimidazole carboxylase; EC=4.1.1.21; AltName: Full=AIR carboxylase; Short=AIRC;. Gene name Name=Paics Synonyms=Ade2, Airc Annotated species Rattus [TaxID: 10114] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae. References [1]   2D-PAGE GEL CHARACTERIZATION DOI=10.1002/pmic.201000593; Burniston J.G., Kenyani J., Wastling J.M., Burant C.F., Qi N.R., Koch L.G., Britton S.L. ''Proteomic analysis reveals perturbed energy metabolism and elevated oxidative stress in hearts of rats with inborn low aerobic capacity'' Proteomics 11(16):3369-3379 (2011) 2D PAGE maps for identified proteins How to interpret a protein HCR_LCR_HEART {HCR LCR Cardiac Map} Rattus Tissue: Heart   map experimental info   HCR_LCR_HEART MAP LOCATIONS: SPOT 161: pI=7.87; Mw=47807   [identification data] IDENTIFICATION: SPOT 161: SeqCov=12.5%. Peptides MS=6/20. Mascot PMF Score=35 [1]. PEPTIDE EVIDENCE: SPOT 161: 293-TIPWLENR-300 (56) / 148-EGLLLWCQR-156 (40) [1]. MAPPING (identification): SPOT 161: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Jatin Burniston, Liverpool John Moores University, UK Cross-references UniProtKB/Swiss-Prot P51583; PUR6_RAT. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_11 Entry name PUR6_RAT Primary accession number P51583 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  November 16, 2011 (version 86) Name and origin of the protein Description RecName: Full=Multifunctional protein ADE2; Includes: RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase; EC=6.3.2.6; AltName: Full=SAICAR synthetase; Includes: RecName: Full=Phosphoribosylaminoimidazole carboxylase; EC=4.1.1.21; AltName: Full=AIR carboxylase; Short=AIRC; Gene name Name=Paics Synonyms=Ade2, Airc Encoded on Name=Paics; Synonyms=Ade2, Airc Keywords Acetylation; ATP-binding; Complete proteome; Decarboxylase; Ligase; Lyase; Multifunctional enzyme; Nucleotide-binding; Phosphoprotein; Purine biosynthesis; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D37979; BAA07197.1; -; mRNA EMBL BC072508; AAH72508.1; -; mRNA EMBL BC085711; AAH85711.1; -; mRNA IPI IPI00203391; -; . PIR S55684; S55684; . RefSeq NP_543186.1; NM_080910.3; . UniGene Rn.3015; -; . ProteinModelPortal P51583; -; . SMR P51583; 7-425; . IntAct P51583; 1; . STRING P51583; -; . PRIDE P51583; -; . Ensembl ENSRNOT00000063942; ENSRNOP00000061495; ENSRNOG00000002101; . GeneID 140946; -; . KEGG rno:140946; -; . UCSC NM_080910; rat; . CTD 10606; -; . RGD 620066; Paics; . eggNOG roNOG04033; -; . GeneTree ENSGT00390000010172; -; . HOVERGEN HBG008335; -; . InParanoid P51583; -; . OrthoDB EOG44BB27; -; . PhylomeDB P51583; -; . NextBio 620860; -; . ArrayExpress P51583; -; . Genevestigator P51583; -; . GermOnline ENSRNOG00000002101; Rattus norvegicus; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0004638; F:phosphoribosylaminoimidazole carboxylase activity; IEA:EC; . GO GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IEA:EC; . GO GO:0006189; P:'de novo' IMP biosynthetic process; IEA:InterPro; . GO GO:0000082; P:G1/S transition of mitotic cell cycle; IEP:RGD; . InterPro IPR000031; AIR_COase_core; . InterPro IPR013816; ATP_grasp_subdomain_2; . InterPro IPR001636; SAICAR_synth; . InterPro IPR018236; SAICAR_synthetase_CS; . Gene3D G3DSA:3.40.50.7700; AIR_carboxyl; 1; . Gene3D G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1; . KO K01587; -; . PANTHER PTHR11609; SAICAR_synt; 1; . Pfam PF00731; AIRC; 1; . Pfam PF01259; SAICAR_synt; 1; . SUPFAM SSF52255; AIR_carboxyl; 1; . TIGRFAMs TIGR01162; PurE; 1; . PROSITE PS01057; SAICAR_SYNTHETASE_1; 1; . PROSITE PS01058; SAICAR_SYNTHETASE_2; 1; . World-2DPAGE Repository (search AC)