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World-2DPAGE Repository

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Searching in 'World-2DPAGE Repository [0027]' for entry matching: P58771

World-2DPAGE Repository (0027):  P58771


General information about the entry
View entry in simple text format
Entry nameTPM1_MOUSE
Primary accession numberP58771
integrated into World-2DPAGE Repository (0027) on September 30, 2010 (release 1)
2D Annotations were last modified onJune 21, 2011 (version 2)
General Annotations were last modified on November 23, 2011 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Tropomyosin alpha-1 chain; AltName: Full=Alpha-tropomyosin; AltName: Full=Tropomyosin-1;.
Gene nameName=Tpm1
Synonyms=Tpm-1, Tpma
Annotated speciesMus musculus (Mouse) [TaxID: 10090]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus.
Blutke A., Block C., Berendt F., Herbach N., Kemter E., Amann K., Frolich T., Arnold G.J., Wanke R.
''Differential glomerular proteome analysis of two murine nephropathy models at onset of albuminuria''
Proteomics - Clinical Applications 5(6):375-381 (2011)
2D PAGE maps for identified proteins
How to interpret a protein

GH_4-7 {glomerular protein lysates of a GH-tg animal}
Mus musculus (Mouse)
  map experimental info

pI=4.50; Mw=37000  [identification data]

SPOT 15: Avg ratio GH-tg vs. control=2.13 (p-value=0.0011) [1].

IDENTIFICATION: SPOT 15: SeqCov=44%. Mascot protein score=199 [1].
MAPPING (identification):
SPOT 15: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

GIPRDN_4-7 {glomerular protein lysates of a GIPRdn-tg animal}
Mus musculus (Mouse)
  map experimental info

pI=4.61; Mw=34000  [identification data]

SPOT 24: Avg ratio GIPRdn-tg vs. control=1.81 (p-value=0.0016) [1].

IDENTIFICATION: SPOT 24: SeqCov=35%. Mascot protein score=211 [1].
MAPPING (identification):
SPOT 24: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Data from Dr. Andreas Blutke, Institute of Veterinary Pathology, University Munich, Germany
UniProtKB/Swiss-ProtP58771; TPM1_MOUSE.
World-2DPAGE RepositoryP58771; TPM1_MOUSE.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_11
Entry nameTPM1_MOUSE
Primary accession numberP58771
Secondary accession number(s) P02558 P19354 P46902 P99034
Sequence was last modified on July 21, 1986 (version 1)
Annotations were last modified on November 16, 2011 (version 81)
Name and origin of the protein
DescriptionRecName: Full=Tropomyosin alpha-1 chain; AltName: Full=Alpha-tropomyosin; AltName: Full=Tropomyosin-1;
Gene nameName=Tpm1
Synonyms=Tpm-1, Tpma
Encoded onName=Tpm1; Synonyms=Tpm-1, Tpma
KeywordsAcetylation; Actin-binding; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Isopeptide bond; Muscle protein; Phosphoprotein; Reference proteome; Ubl conjugation.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLX64831; CAA46043.1; -; mRNA
EMBLM22479; AAA40483.1; -; mRNA
IPIIPI00123316; -; .
IPIIPI00227835; -; .
PIRA31380; A60597; .
RefSeqNP_001157720.1; NM_001164248.1; .
RefSeqNP_077745.2; NM_024427.4; .
UniGeneMm.121878; -; .
ProteinModelPortalP58771; -; .
SMRP58771; 8-284; .
DIPDIP-300N; -; .
IntActP58771; 6; .
STRINGP58771; -; .
PhosphoSiteP58771; -; .
SWISS-2DPAGEP58771; -; .
PRIDEP58771; -; .
EnsemblENSMUST00000113685; ENSMUSP00000109315; ENSMUSG00000032366; .
EnsemblENSMUST00000113707; ENSMUSP00000109337; ENSMUSG00000032366; .
GeneID22003; -; .
KEGGmmu:22003; -; .
CTD7168; -; .
MGIMGI:98809; Tpm1; .
HOVERGENHBG107404; -; .
OrthoDBEOG4TXBSM; -; .
ArrayExpressP58771; -; .
BgeeP58771; -; .
CleanExMM_TPM1; -; .
GenevestigatorP58771; -; .
GermOnlineENSMUSG00000032366; Mus musculus; .
GOGO:0005862; C:muscle thin filament tropomyosin; TAS:MGI; .
GOGO:0003779; F:actin binding; IEA:UniProtKB-KW; .
GOGO:0005200; F:structural constituent of cytoskeleton; TAS:MGI; .
GOGO:0060048; P:cardiac muscle contraction; IMP:BHF-UCL; .
GOGO:0001701; P:in utero embryonic development; IMP:MGI; .
GOGO:0003065; P:positive regulation of heart rate by epinephrine; IMP:BHF-UCL; .
GOGO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IMP:BHF-UCL; .
InterProIPR000533; Tropomyosin; .
KOK10373; -; .
PfamPF00261; Tropomyosin; 1; .

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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server