World-2DPAGE Repository

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.

References

[1]	2D-PAGE GEL CHARACTERIZATION DOI=10.1111/j.1471-4159.2010.06719.x; VanGuilder H.D., Yan H., Farley J.A., Sonntag W.E., Freeman W.M. ''Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome'' J of Neurochemistry 113(6):1577-1588 (2010)

2D PAGE maps for identified proteins

How to interpret a protein

HIPP_SYNAP {Rat hippocampal synaptoproteome}
Rattus norvegicus (Rat)
Tissue: Hippocampus

map experimental info

HIPP_SYNAP

MAP LOCATIONS:

SPOT 625:

pI=5.21; Mw=36122

[identification data]

SPOT 627:

pI=5.21; Mw=36122

[identification data]

IDENTIFICATION: SPOT 625: Peptides number=6. SeqCov=20.4%. MOWSE score=1.92E+3 [1]
SPOT 627: Peptides number=8. SeqCov=28.5%. MOWSE score=2.36E+5 [1].
MAPPING (identification):

SPOT 625: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1];
SPOT 627: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Copyright

Data from Dr. Willard Freeman, Penn State College of Medicine, USA

Cross-references

UniProtKB/Swiss-Prot

P62714; PP2AB_HUMAN.

2D PAGE maps for identified proteins
How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_12
Entry name	PP2AB_HUMAN
Primary accession number	P62714
Secondary accession number(s)	D3DSV4 P11082 Q6FHK5
Sequence was last modified on	July 19, 2004 (version 1)
Annotations were last modified on	December 14, 2011 (version 86)
Name and origin of the protein
Description	RecName: Full=Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; Short=PP2A-beta; EC=3.1.3.16;
Gene name	Name=PPP2CB
Encoded on	Name=PPP2CB
Keywords	Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Hydrolase; Iron; Manganese; Metal-binding; Methylation; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL	X12656; CAA31183.1; -; mRNA
EMBL	CR541747; CAG46547.1; -; mRNA
EMBL	J03805; AAB38020.1; -; mRNA
EMBL	CH471080; EAW63434.1; -; Genomic_DNA
EMBL	CH471080; EAW63435.1; -; Genomic_DNA
EMBL	CH471080; EAW63436.1; -; Genomic_DNA
EMBL	BC012022; AAH12022.1; -; mRNA
EMBL	M60484; AAA36467.1; -; Genomic_DNA
IPI	IPI00429689; -; .
PIR	B37135; PAHU2B; .
RefSeq	NP_001009552.1; NM_001009552.1; .
UniGene	Hs.491440; -; .
ProteinModelPortal	P62714; -; .
SMR	P62714; 6-293; .
IntAct	P62714; 56; .
MINT	MINT-1348293; -; .
STRING	P62714; -; .
PhosphoSite	P62714; -; .
DMDM	50402236; -; .
OGP	P62714; -; .
REPRODUCTION-2DPAGE	IPI00429689; -; .
PRIDE	P62714; -; .
Ensembl	ENST00000221138; ENSP00000221138; ENSG00000104695; .
Ensembl	ENST00000397308; ENSP00000380475; ENSG00000104695; .
Ensembl	ENST00000406655; ENSP00000384493; ENSG00000104695; .
GeneID	5516; -; .
KEGG	hsa:5516; -; .
UCSC	uc003xik.1; human; .
CTD	5516; -; .
GeneCards	GC08M029189; -; .
H-InvDB	HIX0007439; -; .
HGNC	HGNC:9300; PPP2CB; .
HPA	CAB018600; -; .
MIM	176916; gene; .
neXtProt	NX_P62714; -; .
PharmGKB	PA33664; -; .
eggNOG	prNOG16980; -; .
HOGENOM	HBG716770; -; .
HOVERGEN	HBG000216; -; .
InParanoid	P62714; -; .
OMA	VENDIFC; -; .
OrthoDB	EOG4Q58PR; -; .
PhylomeDB	P62714; -; .
Pathway_Interaction_DB	tgfbrpathway; TGF-beta receptor signaling; .
Reactome	REACT_111102; Signal Transduction; .
Reactome	REACT_111217; Metabolism; .
Reactome	REACT_152; Cell Cycle; Mitotic; .
Reactome	REACT_383; DNA Replication; .
Reactome	REACT_474; Metabolism of carbohydrates; .
Reactome	REACT_604; Hemostasis; .
Reactome	REACT_6900; Immune System; .
DrugBank	DB00163; Vitamin E; .
NextBio	21334; -; .
ArrayExpress	P62714; -; .
Bgee	P62714; -; .
CleanEx	HS_PPP2CB; -; .
Genevestigator	P62714; -; .
GermOnline	ENSG00000104695; Homo sapiens; .
GO	GO:0000775; C:chromosome; centromeric region; IEA:UniProtKB-SubCell
GO	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell; .
GO	GO:0005634; C:nucleus; IEA:UniProtKB-SubCell; .
GO	GO:0000159; C:protein phosphatase type 2A complex; TAS:UniProtKB; .
GO	GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell; .
GO	GO:0046872; F:metal ion binding; IEA:UniProtKB-KW; .
GO	GO:0006470; P:protein dephosphorylation; TAS:UniProtKB; .
InterPro	IPR004843; Metallo_PEstase_dom; .
InterPro	IPR006186; Ser/Thr-sp_prot-phosphatase; .
KO	K04382; -; .
Pfam	PF00149; Metallophos; 1; .
PRINTS	PR00114; STPHPHTASE; .
SMART	SM00156; PP2Ac; 1; .
PROSITE	PS00125; SER_THR_PHOSPHATASE; 1; .

World-2DPAGE Repository (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server

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