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Searching in 'World-2DPAGE Repository [0019]' for entry matching: P62714




World-2DPAGE Repository (0019):  P62714


P62714


General information about the entry
View entry in simple text format
Entry namePP2AB_HUMAN
Primary accession numberP62714
Secondary accession number(s) Q6FHK5
integrated into World-2DPAGE Repository (0019) on December 9, 2009 (release 1)
2D Annotations were last modified onMay 30, 2011 (version 2)
General Annotations were last modified on January 13, 2012 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; Short=PP2A-beta; EC=3.1.3.16;.
Gene nameName=PPP2CB
Annotated speciesRattus norvegicus (Rat) [TaxID: 10116]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
References
[1]   2D-PAGE GEL CHARACTERIZATION
DOI=10.1111/j.1471-4159.2010.06719.x;
VanGuilder H.D., Yan H., Farley J.A., Sonntag W.E., Freeman W.M.
''Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome''
J of Neurochemistry 113(6):1577-1588 (2010)
2D PAGE maps for identified proteins
How to interpret a protein

HIPP_SYNAP {Rat hippocampal synaptoproteome}
Rattus norvegicus (Rat)
Tissue: Hippocampus
HIPP_SYNAP
  map experimental info
 
HIPP_SYNAP

MAP LOCATIONS:
pI=5.21; Mw=36122  [identification data]
pI=5.21; Mw=36122  [identification data]

IDENTIFICATION: SPOT 625: Peptides number=6. SeqCov=20.4%. MOWSE score=1.92E+3 [1]
SPOT 627: Peptides number=8. SeqCov=28.5%. MOWSE score=2.36E+5 [1].
MAPPING (identification):
SPOT 625: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1];
SPOT 627: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Copyright
Data from Dr. Willard Freeman, Penn State College of Medicine, USA
Cross-references
UniProtKB/Swiss-ProtP62714; PP2AB_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_12
Entry namePP2AB_HUMAN
Primary accession numberP62714
Secondary accession number(s) D3DSV4 P11082 Q6FHK5
Sequence was last modified on July 19, 2004 (version 1)
Annotations were last modified on December 14, 2011 (version 86)
Name and origin of the protein
DescriptionRecName: Full=Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; Short=PP2A-beta; EC=3.1.3.16;
Gene nameName=PPP2CB
Encoded onName=PPP2CB
KeywordsCentromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Hydrolase; Iron; Manganese; Metal-binding; Methylation; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX12656; CAA31183.1; -; mRNA
EMBLCR541747; CAG46547.1; -; mRNA
EMBLJ03805; AAB38020.1; -; mRNA
EMBLCH471080; EAW63434.1; -; Genomic_DNA
EMBLCH471080; EAW63435.1; -; Genomic_DNA
EMBLCH471080; EAW63436.1; -; Genomic_DNA
EMBLBC012022; AAH12022.1; -; mRNA
EMBLM60484; AAA36467.1; -; Genomic_DNA
IPIIPI00429689; -; .
PIRB37135; PAHU2B; .
RefSeqNP_001009552.1; NM_001009552.1; .
UniGeneHs.491440; -; .
ProteinModelPortalP62714; -; .
SMRP62714; 6-293; .
IntActP62714; 56; .
MINTMINT-1348293; -; .
STRINGP62714; -; .
PhosphoSiteP62714; -; .
DMDM50402236; -; .
OGPP62714; -; .
REPRODUCTION-2DPAGEIPI00429689; -; .
PRIDEP62714; -; .
EnsemblENST00000221138; ENSP00000221138; ENSG00000104695; .
EnsemblENST00000397308; ENSP00000380475; ENSG00000104695; .
EnsemblENST00000406655; ENSP00000384493; ENSG00000104695; .
GeneID5516; -; .
KEGGhsa:5516; -; .
UCSCuc003xik.1; human; .
CTD5516; -; .
GeneCardsGC08M029189; -; .
H-InvDBHIX0007439; -; .
HGNCHGNC:9300; PPP2CB; .
HPACAB018600; -; .
MIM176916; gene; .
neXtProtNX_P62714; -; .
PharmGKBPA33664; -; .
eggNOGprNOG16980; -; .
HOGENOMHBG716770; -; .
HOVERGENHBG000216; -; .
InParanoidP62714; -; .
OMAVENDIFC; -; .
OrthoDBEOG4Q58PR; -; .
PhylomeDBP62714; -; .
Pathway_Interaction_DBtgfbrpathway; TGF-beta receptor signaling; .
ReactomeREACT_111102; Signal Transduction; .
ReactomeREACT_111217; Metabolism; .
ReactomeREACT_152; Cell Cycle; Mitotic; .
ReactomeREACT_383; DNA Replication; .
ReactomeREACT_474; Metabolism of carbohydrates; .
ReactomeREACT_604; Hemostasis; .
ReactomeREACT_6900; Immune System; .
DrugBankDB00163; Vitamin E; .
NextBio21334; -; .
ArrayExpressP62714; -; .
BgeeP62714; -; .
CleanExHS_PPP2CB; -; .
GenevestigatorP62714; -; .
GermOnlineENSG00000104695; Homo sapiens; .
GOGO:0000775; C:chromosome; centromeric region; IEA:UniProtKB-SubCell
GOGO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell; .
GOGO:0005634; C:nucleus; IEA:UniProtKB-SubCell; .
GOGO:0000159; C:protein phosphatase type 2A complex; TAS:UniProtKB; .
GOGO:0000922; C:spindle pole; IEA:UniProtKB-SubCell; .
GOGO:0046872; F:metal ion binding; IEA:UniProtKB-KW; .
GOGO:0006470; P:protein dephosphorylation; TAS:UniProtKB; .
InterProIPR004843; Metallo_PEstase_dom; .
InterProIPR006186; Ser/Thr-sp_prot-phosphatase; .
KOK04382; -; .
PfamPF00149; Metallophos; 1; .
PRINTSPR00114; STPHPHTASE; .
SMARTSM00156; PP2Ac; 1; .
PROSITEPS00125; SER_THR_PHOSPHATASE; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server