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Searching in 'World-2DPAGE Repository [0019]' for entry matching: P62736




World-2DPAGE Repository (0019):  P62736

P62736


General information about the entry
View entry in simple text format
Entry nameACTA_HUMAN
Primary accession numberP62736
integrated into World-2DPAGE Repository (0019) on December 9, 2009 (release 1)
2D Annotations were last modified onMay 30, 2011 (version 2)
General Annotations were last modified on January 13, 2012 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Actin, aortic smooth muscle; AltName: Full=Alpha-actin-2; AltName: Full=Cell growth-inhibiting gene 46 protein; Flags: Precursor;.
Gene nameName=ACTA2
Synonyms=ACTSA, ACTVS
ORFNames=GIG46
Annotated speciesRattus norvegicus (Rat) [TaxID: 10116]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
References
[1]   2D-PAGE GEL CHARACTERIZATION
DOI=10.1111/j.1471-4159.2010.06719.x;
VanGuilder H.D., Yan H., Farley J.A., Sonntag W.E., Freeman W.M.
''Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome''
J of Neurochemistry 113(6):1577-1588 (2010)
2D PAGE maps for identified proteins
How to interpret a protein

HIPP_SYNAP {Rat hippocampal synaptoproteome}
Rattus norvegicus (Rat)
Tissue: Hippocampus
HIPP_SYNAP
  map experimental info 		 
HIPP_SYNAP

MAP LOCATIONS:
pI=5.23; Mw=42380  [identification data]

IDENTIFICATION: SPOT 1016: Peptides number=3. SeqCov=5.6%. MOWSE score=3.11E+2 [1].
MAPPING (identification):
SPOT 1016: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Copyright
Data from Dr. Willard Freeman, Penn State College of Medicine, USA
Cross-references
UniProtKB/Swiss-ProtP62736; ACTA_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_12
Entry nameACTA_HUMAN
Primary accession numberP62736
Secondary accession number(s) B2R8A4 P03996 P04108 Q6FI19
Sequence was last modified on August 16, 2004 (version 1)
Annotations were last modified on December 14, 2011 (version 88)
Name and origin of the protein
DescriptionRecName: Full=Actin, aortic smooth muscle; AltName: Full=Alpha-actin-2; AltName: Full=Cell growth-inhibiting gene 46 protein; Flags: Precursor;
Gene nameName=ACTA2
Synonyms=ACTSA, ACTVS
ORFNames=GIG46
Encoded onName=ACTA2; Synonyms=ACTSA, ACTVS; ORFNames=GIG46
KeywordsAcetylation; Aortic aneurysm; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Methylation; Muscle protein; Nitration; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX13839; CAA32064.1; -; mRNA
EMBLJ05192; AAA51577.1; -; mRNA
EMBLAY692464; AAW29811.1; -; mRNA
EMBLCR536518; CAG38756.1; -; mRNA
EMBLAK313294; BAG36101.1; -; mRNA
EMBLAL157394; CAI13864.1; -; Genomic_DNA
EMBLCH471066; EAW50153.1; -; Genomic_DNA
EMBLBC017554; AAH17554.1; -; mRNA
EMBLBC093052; AAH93052.1; -; mRNA
EMBLK01741; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLK01742; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLK01743; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLM33216; AAA60560.1; -; Genomic_DNA
IPIIPI00008603; -; .
PIRA35020; ATHUSM; .
RefSeqNP_001135417.1; NM_001141945.1; .
RefSeqNP_001604.1; NM_001613.2; .
UniGeneHs.500483; -; .
ProteinModelPortalP62736; -; .
SMRP62736; 6-377; .
IntActP62736; 10; .
STRINGP62736; -; .
PhosphoSiteP62736; -; .
DMDM51316972; -; .
REPRODUCTION-2DPAGEIPI00008603; -; .
UCD-2DPAGEP62736; -; .
PRIDEP62736; -; .
EnsemblENST00000224784; ENSP00000224784; ENSG00000107796; .
EnsemblENST00000458208; ENSP00000402373; ENSG00000107796; .
GeneID59; -; .
KEGGhsa:59; -; .
UCSCuc001kfp.1; human; .
CTD59; -; .
GeneCardsGC10M084329; -; .
H-InvDBHIX0009016; -; .
HGNCHGNC:130; ACTA2; .
HPACAB000002; -; .
MIM102620; gene; .
MIM611788; phenotype; .
MIM613834; phenotype; .
MIM614042; phenotype; .
neXtProtNX_P62736; -; .
Orphanet91387; Familial thoracic aortic aneurysm; .
Orphanet2573; Moyamoya disease; .
eggNOGprNOG14394; -; .
HOGENOMHBG559892; -; .
HOVERGENHBG003771; -; .
InParanoidP62736; -; .
OMANSICVIL; -; .
OrthoDBEOG4W9J40; -; .
PhylomeDBP62736; -; .
ReactomeREACT_17044; Muscle contraction; .
NextBio249; -; .
PMAP-CutDBP62736; -; .
ArrayExpressP62736; -; .
BgeeP62736; -; .
CleanExHS_ACTA2; -; .
GenevestigatorP62736; -; .
GermOnlineENSG00000107796; Homo sapiens; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0005524; F:ATP binding; IEA:UniProtKB-KW; .
GOGO:0009615; P:response to virus; IEP:UniProtKB; .
InterProIPR004000; Actin-like; .
InterProIPR020902; Actin/actin-like_CS; .
InterProIPR004001; Actin_CS; .
KOK12313; -; .
PANTHERPTHR11937; Actin_like; 1; .
PfamPF00022; Actin; 1; .
PRINTSPR00190; ACTIN; .
SMARTSM00268; ACTIN; 1; .
PROSITEPS00406; ACTINS_1; 1; .
PROSITEPS00432; ACTINS_2; 1; .
PROSITEPS01132; ACTINS_ACT_LIKE; 1; .


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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server