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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0019]' for entry matching: P63010 World-2DPAGE Repository (0019):  P63010 P63010 General information about the entry View entry in simple text format Entry name AP2B1_HUMAN Primary accession number P63010 integrated into World-2DPAGE Repository (0019) on  December 9, 2009 (release 1) 2D Annotations were last modified on May 30, 2011 (version 2) General Annotations were last modified on  January 13, 2012 (version 2) Name and origin of the protein Description RecName: Full=AP-2 complex subunit beta; AltName: Full=AP105B; AltName: Full=Adapter-related protein complex 2 beta subunit; AltName: Full=Adaptor protein complex AP-2 subunit beta; AltName: Full=Beta-2-adaptin; AltName: Full=Beta-adaptin; AltName: Full=Clathrin assembly protein complex 2 beta large chain; AltName: Full=Plasma membrane adaptor HA2/AP2 adaptin beta subunit;. Gene name Name=AP2B1 Synonyms=ADTB2, CLAPB1 Annotated species Rattus norvegicus (Rat) [TaxID: 10116] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus. References [1]   2D-PAGE GEL CHARACTERIZATION DOI=10.1111/j.1471-4159.2010.06719.x; VanGuilder H.D., Yan H., Farley J.A., Sonntag W.E., Freeman W.M. ''Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome'' J of Neurochemistry 113(6):1577-1588 (2010) 2D PAGE maps for identified proteins How to interpret a protein HIPP_SYNAP {Rat hippocampal synaptoproteome} Rattus norvegicus (Rat) Tissue: Hippocampus   map experimental info   HIPP_SYNAP MAP LOCATIONS: SPOT 144: pI=5.22; Mw=105398   [identification data] IDENTIFICATION: SPOT 144: Peptides number=7. SeqCov=8.1%. MOWSE score=1.32E+6 [1]. MAPPING (identification): SPOT 144: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Willard Freeman, Penn State College of Medicine, USA Cross-references UniProtKB/Swiss-Prot P63010; AP2B1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_12 Entry name AP2B1_HUMAN Primary accession number P63010 Secondary accession number(s) A6NJP3 P21851 Q96J19 Sequence was last modified on  August 31, 2004 (version 1) Annotations were last modified on  December 14, 2011 (version 90) Name and origin of the protein Description RecName: Full=AP-2 complex subunit beta; AltName: Full=AP105B; AltName: Full=Adapter-related protein complex 2 beta subunit; AltName: Full=Adaptor protein complex AP-2 subunit beta; AltName: Full=Beta-2-adaptin; AltName: Full=Beta-adaptin; AltName: Full=Clathrin assembly protein complex 2 beta large chain; AltName: Full=Plasma membrane adaptor HA2/AP2 adaptin beta subunit; Gene name Name=AP2B1 Synonyms=ADTB2, CLAPB1 Encoded on Name=AP2B1; Synonyms=ADTB2, CLAPB1 Keywords 3D-structure; Acetylation; Alternative splicing; Cell membrane; Coated pit; Complete proteome; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M34175; AAA35583.1; -; mRNA EMBL AC006237; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471147; EAW80133.1; -; Genomic_DNA EMBL BC006201; AAH06201.1; -; mRNA IPI IPI00784156; -; . IPI IPI00784366; -; . PIR A35553; A35553; . RefSeq NP_001025177.1; NM_001030006.1; . RefSeq NP_001273.1; NM_001282.2; . UniGene Hs.514819; -; . PDB 1E42; X-ray; 1.70 A; A/B=701-937 PDB 2G30; X-ray; 1.60 A; A=701-937 PDB 2IV8; X-ray; 2.80 A; A=700-937 PDB 2IV9; X-ray; 1.90 A; A/B=700-937 PDB 2JKR; X-ray; 2.98 A; B/E=1-591 PDB 2JKT; X-ray; 3.40 A; B/E=1-591 PDB 2VGL; X-ray; 2.59 A; B=1-591 PDB 2XA7; X-ray; 3.10 A; B=1-592 PDBsum 1E42; -; . PDBsum 2G30; -; . PDBsum 2IV8; -; . PDBsum 2IV9; -; . PDBsum 2JKR; -; . PDBsum 2JKT; -; . PDBsum 2VGL; -; . PDBsum 2XA7; -; . ProteinModelPortal P63010; -; . SMR P63010; 4-582; 705-937; . IntAct P63010; 32; . MINT MINT-256705; -; . STRING P63010; -; . PhosphoSite P63010; -; . DMDM 51702211; -; . PRIDE P63010; -; . Ensembl ENST00000262325; ENSP00000262325; ENSG00000006125; . GeneID 163; -; . KEGG hsa:163; -; . UCSC uc002hjq.1; human; . UCSC uc002hjr.1; human; . CTD 163; -; . GeneCards GC17P030099; -; . HGNC HGNC:563; AP2B1; . HPA CAB017631; -; . MIM 601025; gene; . neXtProt NX_P63010; -; . PharmGKB PA24854; -; . eggNOG prNOG09520; -; . HOVERGEN HBG050515; -; . OMA DCHLNAD; -; . OrthoDB EOG4PG607; -; . PhylomeDB P63010; -; . Reactome REACT_111045; Developmental Biology; . Reactome REACT_111102; Signal Transduction; . Reactome REACT_13685; Neuronal System; . Reactome REACT_6185; HIV Infection; . NextBio 653; -; . ArrayExpress P63010; -; . Bgee P63010; -; . CleanEx HS_AP2B1; -; . Genevestigator P63010; -; . GermOnline ENSG00000006125; Homo sapiens; . GO GO:0030131; C:clathrin adaptor complex; IEA:InterPro; . GO GO:0005905; C:coated pit; IEA:UniProtKB-SubCell; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0030666; C:endocytic vesicle membrane; TAS:Reactome; . GO GO:0005886; C:plasma membrane; TAS:Reactome; . GO GO:0030276; F:clathrin binding; IPI:UniProtKB; . GO GO:0008565; F:protein transporter activity; IEA:InterPro; . GO GO:0007411; P:axon guidance; TAS:Reactome; . GO GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome; . GO GO:0006886; P:intracellular protein transport; IEA:InterPro; . GO GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome; . GO GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome; . GO GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome; . GO GO:0007268; P:synaptic transmission; TAS:Reactome; . GO GO:0016192; P:vesicle-mediated transport; IEA:InterPro; . GO GO:0016032; P:viral reproduction; TAS:Reactome; . InterPro IPR016342; AP_complex_bsu; . InterPro IPR011989; ARM-like; . InterPro IPR016024; ARM-type_fold; . InterPro IPR012295; Beta2_adaptin/TATA-box-bd_C; . InterPro IPR002553; Clathrin/coatomer_adapt-like_N; . InterPro IPR008152; Clathrin_a/b/g-adaptin_app_Ig; . InterPro IPR013037; Clathrin_b-adaptin_app_Ig-like; . InterPro IPR015151; Clathrin_b-adaptin_app_sub_C; . InterPro IPR009028; Coatomer/calthrin_app_sub_C; . InterPro IPR013041; Coatomer/clathrin_app_Ig-like; . Gene3D G3DSA:1.25.10.10; ARM-like; 1; . Gene3D G3DSA:3.30.310.10; b_Adaptin_TBP_C; 1; . Gene3D G3DSA:2.60.40.1150; Clathrin_b-adaptin_app_Ig-like; 1; . KO K11825; -; . Pfam PF01602; Adaptin_N; 1; . Pfam PF02883; Alpha_adaptinC2; 1; . Pfam PF09066; B2-adapt-app_C; 1; . PIRSF PIRSF002291; AP_complex_beta; 1; . SMART SM00809; Alpha_adaptinC2; 1; . SUPFAM SSF55711; AP2_adap_app; 1; . SUPFAM SSF48371; ARM-type_fold; 1; . SUPFAM SSF49348; Clath_adapt; 1; . World-2DPAGE Repository (search AC)