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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0019]' for entry matching: PP2BA_RAT World-2DPAGE Repository (0019):  PP2BA_RAT PP2BA_RAT General information about the entry View entry in simple text format Entry name PP2BA_RAT Primary accession number P63329 integrated into World-2DPAGE Repository (0019) on  December 9, 2009 (release 1) 2D Annotations were last modified on May 30, 2011 (version 2) General Annotations were last modified on  January 13, 2012 (version 2) Name and origin of the protein Description RecName: Full=Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; EC=3.1.3.16; AltName: Full=CAM-PRP catalytic subunit; AltName: Full=Calmodulin-dependent calcineurin A subunit alpha isoform;. Gene name Name=Ppp3ca Synonyms=Calna Annotated species Rattus norvegicus (Rat) [TaxID: 10116] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus. References [1]   2D-PAGE GEL CHARACTERIZATION DOI=10.1111/j.1471-4159.2010.06719.x; VanGuilder H.D., Yan H., Farley J.A., Sonntag W.E., Freeman W.M. ''Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome'' J of Neurochemistry 113(6):1577-1588 (2010) 2D PAGE maps for identified proteins How to interpret a protein HIPP_SYNAP {Rat hippocampal synaptoproteome} Rattus norvegicus (Rat) Tissue: Hippocampus   map experimental info   HIPP_SYNAP MAP LOCATIONS: SPOT 370: pI=5.58; Mw=59290   [identification data] SPOT 1154: pI=5.58; Mw=59290   [identification data] IDENTIFICATION: SPOT 370: Peptides number=8. SeqCov=15.4%. MOWSE score=5.97E+7 [1] SPOT 1154: Peptides number=8. SeqCov=15.5%. MOWSE score=2.66E+6 [1]. MAPPING (identification): SPOT 370: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]; SPOT 1154: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Willard Freeman, Penn State College of Medicine, USA Cross-references UniProtKB/Swiss-Prot P63329; PP2BA_RAT. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_12 Entry name PP2BA_RAT Primary accession number P63329 Secondary accession number(s) P12816 P20652 Q6LDJ8 Q9WUV7 Q9Z1I5 Sequence was last modified on  October 11, 2004 (version 1) Annotations were last modified on  November 16, 2011 (version 69) Name and origin of the protein Description RecName: Full=Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; EC=3.1.3.16; AltName: Full=CAM-PRP catalytic subunit; AltName: Full=Calmodulin-dependent calcineurin A subunit alpha isoform; Gene name Name=Ppp3ca Synonyms=Calna Encoded on Name=Ppp3ca; Synonyms=Calna Keywords Alternative splicing; Calmodulin-binding; Complete proteome; Direct protein sequencing; Hydrolase; Iron; Metal-binding; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome; Zinc. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D90035; BAA14083.1; -; mRNA EMBL M29275; AAA40940.1; -; mRNA EMBL X57115; CAA40398.2; -; mRNA EMBL D10480; BAA01283.1; -; Genomic_DNA EMBL M58440; AAA41914.1; -; mRNA IPI IPI00201410; -; . IPI IPI00559849; -; . PIR A33264; A33264; . RefSeq NP_058737.1; NM_017041.1; . UniGene Rn.6866; -; . ProteinModelPortal P63329; -; . SMR P63329; 1-372; . STRING P63329; -; . PhosphoSite P63329; -; . PRIDE P63329; -; . GeneID 24674; -; . KEGG rno:24674; -; . UCSC NM_017041; rat; . CTD 5530; -; . RGD 3382; Ppp3ca; . eggNOG roNOG11256; -; . GeneTree ENSGT00530000063087; -; . HOVERGEN HBG002819; -; . InParanoid P63329; -; . OrthoDB EOG4PVNZK; -; . PhylomeDB P63329; -; . NextBio 604055; -; . ArrayExpress P63329; -; . Genevestigator P63329; -; . GermOnline ENSRNOG00000009882; Rattus norvegicus; . GO GO:0005955; C:calcineurin complex; IDA:RGD; . GO GO:0005829; C:cytosol; IDA:RGD; . GO GO:0016020; C:membrane; IDA:RGD; . GO GO:0005634; C:nucleus; IEA:UniProtKB-SubCell; . GO GO:0005625; C:soluble fraction; IDA:RGD; . GO GO:0004723; F:calcium-dependent protein serine/threonine phosphatase activity; IDA:RGD; . GO GO:0005516; F:calmodulin binding; IDA:RGD; . GO GO:0046872; F:metal ion binding; IEA:UniProtKB-KW; . GO GO:0046982; F:protein heterodimerization activity; IDA:RGD; . GO GO:0071333; P:cellular response to glucose stimulus; IMP:BHF-UCL; . GO GO:0045955; P:negative regulation of calcium ion-dependent exocytosis; IC:BHF-UCL; . GO GO:0046676; P:negative regulation of insulin secretion; IMP:BHF-UCL; . GO GO:0006470; P:protein dephosphorylation; IDA:RGD; . GO GO:0001975; P:response to amphetamine; IEP:RGD; . InterPro IPR004843; Metallo_PEstase_dom; . InterPro IPR006186; Ser/Thr-sp_prot-phosphatase; . KO K04348; -; . Pfam PF00149; Metallophos; 1; . PRINTS PR00114; STPHPHTASE; . SMART SM00156; PP2Ac; 1; . PROSITE PS00125; SER_THR_PHOSPHATASE; 1; . 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