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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0022]' for entry matching: PRDX6_RAT World-2DPAGE Repository (0022):  PRDX6_RAT PRDX6_RAT General information about the entry View entry in simple text format Entry name PRDX6_RAT Primary accession number O35244 integrated into World-2DPAGE Repository (0022) on  May 7, 2010 (release 1) 2D Annotations were last modified on June 22, 2011 (version 2) General Annotations were last modified on  November 24, 2011 (version 2) Name and origin of the protein Description RecName: Full=Peroxiredoxin-6; EC=1.11.1.15; AltName: Full=1-Cys peroxiredoxin; Short=1-Cys PRX; AltName: Full=Acidic calcium-independent phospholipase A2; Short=aiPLA2; EC=3.1.1.-; AltName: Full=Antioxidant protein 2; AltName: Full=Non-selenium glutathione peroxidase; Short=NSGPx; EC=1.11.1.9; AltName: Full=Thiol-specific antioxidant protein;. Gene name Name=Prdx6 Synonyms=Aipla2, Aop2, Tsa Annotated species Rattus [TaxID: 10114] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae. References [1]   2D-PAGE GEL CHARACTERIZATION DOI=10.1002/pmic.201000593; Burniston J.G., Kenyani J., Wastling J.M., Burant C.F., Qi N.R., Koch L.G., Britton S.L. ''Proteomic analysis reveals perturbed energy metabolism and elevated oxidative stress in hearts of rats with inborn low aerobic capacity'' Proteomics 11(16):3369-3379 (2011) 2D PAGE maps for identified proteins How to interpret a protein HCR_LCR_HEART {HCR LCR Cardiac Map} Rattus Tissue: Heart   map experimental info   HCR_LCR_HEART MAP LOCATIONS: SPOT 496: pI=5.64; Mw=24860   [identification data] IDENTIFICATION: SPOT 496: SeqCov=48.2%. Peptides MS=8/20. Mascot PMF Score=86 [1]. PEPTIDE EVIDENCE: SPOT 496: 156-NFDEILR-162 (44) / 25-FHDFLGDSWGILFSHPR-41 (103) / 2-PGGLLLGDEAPNFEANTTIGHIR-24 (144) [1]. MAPPING (identification): SPOT 496: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Jatin Burniston, Liverpool John Moores University, UK Cross-references UniProtKB/Swiss-Prot O35244; PRDX6_RAT. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_11 Entry name PRDX6_RAT Primary accession number O35244 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  November 16, 2011 (version 101) Name and origin of the protein Description RecName: Full=Peroxiredoxin-6; EC=1.11.1.15; AltName: Full=1-Cys peroxiredoxin; Short=1-Cys PRX; AltName: Full=Acidic calcium-independent phospholipase A2; Short=aiPLA2; EC=3.1.1.-; AltName: Full=Antioxidant protein 2; AltName: Full=Non-selenium glutathione peroxidase; Short=NSGPx; EC=1.11.1.9; AltName: Full=Thiol-specific antioxidant protein; Gene name Name=Prdx6 Synonyms=Aipla2, Aop2, Tsa Encoded on Name=Prdx6; Synonyms=Aipla2, Aop2, Tsa Keywords Acetylation; Antioxidant; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Direct protein sequencing; Disulfide bond; Hydrolase; Lipid degradation; Lysosome; Multifunctional enzyme; Oxidoreductase; Peroxidase; Phosphoprotein; Redox-active center; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AF014009; AAB66341.1; -; mRNA EMBL Y17295; CAA76732.1; -; mRNA IPI IPI00231260; -; . RefSeq NP_446028.1; NM_053576.2; . UniGene Rn.42; -; . ProteinModelPortal O35244; -; . SMR O35244; 5-224; . IntAct O35244; 1; . STRING O35244; -; . PeroxiBase 4427; Rno1CysPrx; . PhosphoSite O35244; -; . World-2DPAGE 0004:O35244; -; . PRIDE O35244; -; . Ensembl ENSRNOT00000034583; ENSRNOP00000030323; ENSRNOG00000002896; . GeneID 94167; -; . KEGG rno:94167; -; . UCSC NM_053576; rat; . CTD 9588; -; . RGD 71005; Prdx6; . eggNOG roNOG13330; -; . GeneTree ENSGT00550000074794; -; . HOVERGEN HBG105234; -; . InParanoid O35244; -; . OMA NYPILAD; -; . OrthoDB EOG4M399H; -; . PhylomeDB O35244; -; . BRENDA 1.11.1.15; 5301; . NextBio 617808; -; . ArrayExpress O35244; -; . Genevestigator O35244; -; . GermOnline ENSRNOG00000002896; Rattus norvegicus; . GO GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell; . GO GO:0005764; C:lysosome; IEA:UniProtKB-SubCell; . GO GO:0004602; F:glutathione peroxidase activity; IDA:RGD; . GO GO:0051920; F:peroxiredoxin activity; IEA:EC; . GO GO:0005515; F:protein binding; IPI:RGD; . GO GO:0042744; P:hydrogen peroxide catabolic process; IDA:RGD; . InterPro IPR000866; AhpC/TSA; . InterPro IPR024706; Peroxiredoxin_AhpC-typ; . InterPro IPR019479; Peroxiredoxin_C; . InterPro IPR012336; Thioredoxin-like_fold; . Gene3D G3DSA:3.40.30.10; Thioredoxin_fold; 1; . KO K11188; -; . Pfam PF10417; 1-cysPrx_C; 1; . Pfam PF00578; AhpC-TSA; 1; . PIRSF PIRSF000239; AHPC; 1; . SUPFAM SSF52833; Thiordxn-like_fd; 1; . PROSITE PS51352; THIOREDOXIN_2; 1; . World-2DPAGE Repository (search AC)