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Searching in 'World-2DPAGE Repository [0022]' for entry matching: PRDX6_RAT




World-2DPAGE Repository (0022):  PRDX6_RAT

PRDX6_RAT


General information about the entry
View entry in simple text format
Entry namePRDX6_RAT
Primary accession numberO35244
integrated into World-2DPAGE Repository (0022) on May 7, 2010 (release 1)
2D Annotations were last modified onJune 22, 2011 (version 2)
General Annotations were last modified on November 24, 2011 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Peroxiredoxin-6; EC=1.11.1.15; AltName: Full=1-Cys peroxiredoxin; Short=1-Cys PRX; AltName: Full=Acidic calcium-independent phospholipase A2; Short=aiPLA2; EC=3.1.1.-; AltName: Full=Antioxidant protein 2; AltName: Full=Non-selenium glutathione peroxidase; Short=NSGPx; EC=1.11.1.9; AltName: Full=Thiol-specific antioxidant protein;.
Gene nameName=Prdx6
Synonyms=Aipla2, Aop2, Tsa
Annotated speciesRattus [TaxID: 10114]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae.
References
[1]   2D-PAGE GEL CHARACTERIZATION
DOI=10.1002/pmic.201000593;
Burniston J.G., Kenyani J., Wastling J.M., Burant C.F., Qi N.R., Koch L.G., Britton S.L.
''Proteomic analysis reveals perturbed energy metabolism and elevated oxidative stress in hearts of rats with inborn low aerobic capacity''
Proteomics 11(16):3369-3379 (2011)
2D PAGE maps for identified proteins
How to interpret a protein

HCR_LCR_HEART {HCR LCR Cardiac Map}
Rattus
Tissue: Heart
HCR_LCR_HEART
  map experimental info 		 
HCR_LCR_HEART

MAP LOCATIONS:
pI=5.64; Mw=24860  [identification data]

IDENTIFICATION: SPOT 496: SeqCov=48.2%. Peptides MS=8/20. Mascot PMF Score=86 [1].
PEPTIDE EVIDENCE: SPOT 496: 156-NFDEILR-162 (44) / 25-FHDFLGDSWGILFSHPR-41 (103) / 2-PGGLLLGDEAPNFEANTTIGHIR-24 (144) [1].
MAPPING (identification):
SPOT 496: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Copyright
Data from Dr. Jatin Burniston, Liverpool John Moores University, UK
Cross-references
UniProtKB/Swiss-ProtO35244; PRDX6_RAT.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_11
Entry namePRDX6_RAT
Primary accession numberO35244
Sequence was last modified on January 23, 2007 (version 3)
Annotations were last modified on November 16, 2011 (version 101)
Name and origin of the protein
DescriptionRecName: Full=Peroxiredoxin-6; EC=1.11.1.15; AltName: Full=1-Cys peroxiredoxin; Short=1-Cys PRX; AltName: Full=Acidic calcium-independent phospholipase A2; Short=aiPLA2; EC=3.1.1.-; AltName: Full=Antioxidant protein 2; AltName: Full=Non-selenium glutathione peroxidase; Short=NSGPx; EC=1.11.1.9; AltName: Full=Thiol-specific antioxidant protein;
Gene nameName=Prdx6
Synonyms=Aipla2, Aop2, Tsa
Encoded onName=Prdx6; Synonyms=Aipla2, Aop2, Tsa
KeywordsAcetylation; Antioxidant; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Direct protein sequencing; Disulfide bond; Hydrolase; Lipid degradation; Lysosome; Multifunctional enzyme; Oxidoreductase; Peroxidase; Phosphoprotein; Redox-active center; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLAF014009; AAB66341.1; -; mRNA
EMBLY17295; CAA76732.1; -; mRNA
IPIIPI00231260; -; .
RefSeqNP_446028.1; NM_053576.2; .
UniGeneRn.42; -; .
ProteinModelPortalO35244; -; .
SMRO35244; 5-224; .
IntActO35244; 1; .
STRINGO35244; -; .
PeroxiBase4427; Rno1CysPrx; .
PhosphoSiteO35244; -; .
World-2DPAGE0004:O35244; -; .
PRIDEO35244; -; .
EnsemblENSRNOT00000034583; ENSRNOP00000030323; ENSRNOG00000002896; .
GeneID94167; -; .
KEGGrno:94167; -; .
UCSCNM_053576; rat; .
CTD9588; -; .
RGD71005; Prdx6; .
eggNOGroNOG13330; -; .
GeneTreeENSGT00550000074794; -; .
HOVERGENHBG105234; -; .
InParanoidO35244; -; .
OMANYPILAD; -; .
OrthoDBEOG4M399H; -; .
PhylomeDBO35244; -; .
BRENDA1.11.1.15; 5301; .
NextBio617808; -; .
ArrayExpressO35244; -; .
GenevestigatorO35244; -; .
GermOnlineENSRNOG00000002896; Rattus norvegicus; .
GOGO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell; .
GOGO:0005764; C:lysosome; IEA:UniProtKB-SubCell; .
GOGO:0004602; F:glutathione peroxidase activity; IDA:RGD; .
GOGO:0051920; F:peroxiredoxin activity; IEA:EC; .
GOGO:0005515; F:protein binding; IPI:RGD; .
GOGO:0042744; P:hydrogen peroxide catabolic process; IDA:RGD; .
InterProIPR000866; AhpC/TSA; .
InterProIPR024706; Peroxiredoxin_AhpC-typ; .
InterProIPR019479; Peroxiredoxin_C; .
InterProIPR012336; Thioredoxin-like_fold; .
Gene3DG3DSA:3.40.30.10; Thioredoxin_fold; 1; .
KOK11188; -; .
PfamPF10417; 1-cysPrx_C; 1; .
PfamPF00578; AhpC-TSA; 1; .
PIRSFPIRSF000239; AHPC; 1; .
SUPFAMSSF52833; Thiordxn-like_fd; 1; .
PROSITEPS51352; THIOREDOXIN_2; 1; .


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