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World-2DPAGE Repository

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Searching in 'World-2DPAGE Repository [0027]' for entry matching: Q8BTM8




World-2DPAGE Repository (0027):  Q8BTM8


Q8BTM8


General information about the entry
View entry in simple text format
Entry nameFLNA_MOUSE
Primary accession numberQ8BTM8
integrated into World-2DPAGE Repository (0027) on September 30, 2010 (release 1)
2D Annotations were last modified onJune 21, 2011 (version 2)
General Annotations were last modified on November 23, 2011 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Filamin-A; Short=FLN-A; AltName: Full=Actin-binding protein 280; Short=ABP-280; AltName: Full=Alpha-filamin; AltName: Full=Endothelial actin-binding protein; AltName: Full=Filamin-1; AltName: Full=Non-muscle filamin;.
Gene nameName=Flna
Synonyms=Fln, Fln1
Annotated speciesMus musculus (Mouse) [TaxID: 10090]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus.
References
[1]   2D-PAGE GEL CHARACTERIZATION
DOI=10.1002/prca.201000103;
Blutke A., Block C., Berendt F., Herbach N., Kemter E., Amann K., Frolich T., Arnold G.J., Wanke R.
''Differential glomerular proteome analysis of two murine nephropathy models at onset of albuminuria''
Proteomics - Clinical Applications 5(6):375-381 (2011)
2D PAGE maps for identified proteins
How to interpret a protein

GH_4-7 {glomerular protein lysates of a GH-tg animal}
Mus musculus (Mouse)
GH_4-7
  map experimental info
 
GH_4-7

MAP LOCATIONS:
pI=6.30; Mw=99000  [identification data]

EXPRESSION:
SPOT 2: Avg ratio GH-tg vs. control=1.52 (p-value=0.0054) [1].

IDENTIFICATION: SPOT 2: SeqCov=17%. Mascot protein score=305 [1].
MAPPING (identification):
SPOT 2: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Copyright
Data from Dr. Andreas Blutke, Institute of Veterinary Pathology, University Munich, Germany
Cross-references
UniProtKB/Swiss-ProtQ8BTM8; FLNA_MOUSE.
World-2DPAGE RepositoryQ8BTM8; FLNA_MOUSE.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_11
Entry nameFLNA_MOUSE
Primary accession numberQ8BTM8
Secondary accession number(s) B7FAV0 O54934 Q7TQI1 Q8BLK1 Q8BTN7 Q8VHX5 Q8VHX8 Q99KQ2
Sequence was last modified on July 27, 2011 (version 5)
Annotations were last modified on November 16, 2011 (version 100)
Name and origin of the protein
DescriptionRecName: Full=Filamin-A; Short=FLN-A; AltName: Full=Actin-binding protein 280; Short=ABP-280; AltName: Full=Alpha-filamin; AltName: Full=Endothelial actin-binding protein; AltName: Full=Filamin-1; AltName: Full=Non-muscle filamin;
Gene nameName=Flna
Synonyms=Fln, Fln1
Encoded onName=Flna; Synonyms=Fln, Fln1
KeywordsAcetylation; Actin-binding; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome; Repeat.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLAK044856; BAC32121.1; -; mRNA
EMBLAK089195; BAC40787.1; ALT_INIT; mRNA
EMBLAK089311; BAC40837.2; ALT_INIT; mRNA
EMBLAL807376; CAT00728.1; -; Genomic_DNA
EMBLBC004061; AAH04061.1; -; mRNA
EMBLBC038478; -; NOT_ANNOTATED_CDS; mRNA
EMBLBC054432; AAH54432.1; -; mRNA
EMBLAF034129; AAC02062.1; -; mRNA
EMBLAF353668; AAL68444.1; -; mRNA
EMBLAF353671; AAL68447.1; -; mRNA
IPIIPI00131138; -; .
IPIIPI00387373; -; .
RefSeqNP_034357.2; NM_010227.2; .
UniGeneMm.295533; -; .
ProteinModelPortalQ8BTM8; -; .
SMRQ8BTM8; 39-269; 1044-1643; 1773-2329
2331-25222559-2647; .
IntActQ8BTM8; 2; .
MINTMINT-1867095; -; .
STRINGQ8BTM8; -; .
PhosphoSiteQ8BTM8; -; .
PRIDEQ8BTM8; -; .
EnsemblENSMUST00000033699; ENSMUSP00000033699; ENSMUSG00000031328; .
GeneID192176; -; .
KEGGmmu:192176; -; .
CTD2316; -; .
MGIMGI:95556; Flna; .
eggNOGroNOG14400; -; .
HOVERGENHBG004163; -; .
InParanoidQ8BTM8; -; .
NextBio371188; -; .
ArrayExpressQ8BTM8; -; .
BgeeQ8BTM8; -; .
CleanExMM_FLNA; -; .
GenevestigatorQ8BTM8; -; .
GermOnlineENSMUSG00000031328; Mus musculus; .
GOGO:0005938; C:cell cortex; IEA:UniProtKB-SubCell; .
GOGO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell; .
GOGO:0005634; C:nucleus; ISS:UniProtKB; .
GOGO:0005886; C:plasma membrane; ISS:UniProtKB; .
GOGO:0005802; C:trans-Golgi network; IDA:MGI; .
GOGO:0051015; F:actin filament binding; ISS:UniProtKB; .
GOGO:0034988; F:Fc-gamma receptor I complex binding; ISS:UniProtKB; .
GOGO:0001948; F:glycoprotein binding; ISS:UniProtKB; .
GOGO:0005080; F:protein kinase C binding; IDA:MGI; .
GOGO:0048365; F:Rac GTPase binding; ISS:UniProtKB; .
GOGO:0004871; F:signal transducer activity; ISS:UniProtKB; .
GOGO:0008134; F:transcription factor binding; ISS:UniProtKB; .
GOGO:0051764; P:actin crosslink formation; ISS:UniProtKB; .
GOGO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB; .
GOGO:0051220; P:cytoplasmic sequestering of protein; ISS:UniProtKB; .
GOGO:0045022; P:early endosome to late endosome transport; IDA:MGI; .
GOGO:0045184; P:establishment of protein localization; ISS:UniProtKB; .
GOGO:0007195; P:inhibition of adenylate cyclase activity by dopamine receptor signaling pathway; ISS:UniProtKB; .
GOGO:0042177; P:negative regulation of protein catabolic process; ISS:UniProtKB; .
GOGO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; ISS:UniProtKB; .
GOGO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB; .
GOGO:0042993; P:positive regulation of transcription factor import into nucleus; ISS:UniProtKB; .
GOGO:0034394; P:protein localization at cell surface; ISS:UniProtKB; .
GOGO:0050821; P:protein stabilization; ISS:UniProtKB; .
GOGO:0043113; P:receptor clustering; ISS:UniProtKB; .
InterProIPR001589; Actinin_actin-bd_CS; .
InterProIPR001715; CH-domain; .
InterProIPR001298; Filamin; .
InterProIPR017868; Filamin/ABP280_repeat-like; .
InterProIPR013783; Ig-like_fold; .
InterProIPR014756; Ig_E-set; .
Gene3DG3DSA:1.10.418.10; Calponin-homology; 2; .
Gene3DG3DSA:2.60.40.10; Ig-like_fold; 24; .
KOK04437; -; .
PfamPF00307; CH; 2; .
PfamPF00630; Filamin; 23; .
SMARTSM00033; CH; 2; .
SMARTSM00557; IG_FLMN; 24; .
SUPFAMSSF47576; Calponin-homology; 1; .
SUPFAMSSF81296; Ig_E-set; 24; .
PROSITEPS00019; ACTININ_1; 1; .
PROSITEPS00020; ACTININ_2; 1; .
PROSITEPS50021; CH; 2; .
PROSITEPS50194; FILAMIN_REPEAT; 24; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server