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Sample Preparation and Post-separation Analysis Searching in 'SWISS-2DPAGE' for entry matching: P01106 SWISS-2DPAGE:  P01106 P01106 General information about the entry View entry in simple text format Entry name MYC_HUMAN Primary accession number P01106 integrated into SWISS-2DPAGE on  September 1, 1997 (release 6) 2D Annotations were last modified on December 1, 2000 (version 1) General Annotations were last modified on  May 19, 2011 (version 13) Name and origin of the protein Description RecName: Full=Myc proto-oncogene protein; AltName: Full=Class E basic helix-loop-helix protein 39; Short=bHLHe39; AltName: Full=Proto-oncogene c-Myc; AltName: Full=Transcription factor p64;. Gene name Name=MYC Synonyms=BHLHE39 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   MAPPING ON GEL MEDLINE=97295311; PubMed=9150953; [NCBI, Expasy, EBI, Israel, Japan] Sanchez J.-C., Wirth P., Jaccoud S., Appel R.D., Sarto C., Wilkins M.R., Hochstrasser D.F. ''''''Simultaneous analysis of cyclin and oncogene expression using multiple monoclonal antibody immunoblots'';'';'' Electrophoresis 18(1):638-641(1997) 2D PAGE maps for identified proteins How to interpret a protein HEPG2_HUMAN {HepG2} Homo sapiens (Human) Tissue: Hepatoblastoma   map experimental info   protein estimated location   HEPG2_HUMAN MAP LOCATIONS: SPOT 2D-0012IR: pI=5.12; Mw=44719 MAPPING (identification): IMMUNOBLOTTING [1]. LIVER_HUMAN {Liver} Homo sapiens (Human) Tissue: Liver   map experimental info   protein estimated location   LIVER_HUMAN MAP LOCATIONS: SPOT 2D-0010AD: pI=5.15; Mw=44335 MAPPING (identification): IMMUNOBLOTTING [1]. Copyright This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). Cross-references UniProtKB/Swiss-Prot P01106; MYC_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_10 Entry name MYC_HUMAN Primary accession number P01106 Secondary accession number(s) A8WFE7 P01107 Q14026 Sequence was last modified on  August 13, 1987 (version 1) Annotations were last modified on  October 19, 2011 (version 161) Name and origin of the protein Description RecName: Full=Myc proto-oncogene protein; AltName: Full=Class E basic helix-loop-helix protein 39; Short=bHLHe39; AltName: Full=Proto-oncogene c-Myc; AltName: Full=Transcription factor p64; Gene name Name=MYC Synonyms=BHLHE39 Encoded on Name=MYC; Synonyms=BHLHE39 Keywords 3D-structure; Acetylation; Activator; Alternative splicing; Chromosomal rearrangement; Complete proteome; DNA-binding; Glycoprotein; Nucleus; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL L00058; AAA59882.1; -; Genomic_DNA EMBL L00057; AAA59882.1; JOINED; Genomic_DNA EMBL K00535; AAA59880.1; -; Genomic_DNA EMBL K00534; AAA59880.1; JOINED; Genomic_DNA EMBL K00535; ABW69847.1; -; Genomic_DNA EMBL K00534; ABW69847.1; JOINED; Genomic_DNA EMBL X00196; CAA25015.2; -; Genomic_DNA EMBL X00198; CAA25015.2; JOINED; Genomic_DNA EMBL X00364; CAA25106.1; -; Genomic_DNA EMBL V00568; CAA23831.1; -; mRNA EMBL K01906; AAA59881.1; -; Genomic_DNA EMBL K01905; AAA59881.1; JOINED; Genomic_DNA EMBL K02276; AAA36340.1; -; mRNA EMBL X00676; CAA25288.1; -; Genomic_DNA EMBL D10493; BAA01374.2; -; Genomic_DNA EMBL D10493; BAA01375.1; -; Genomic_DNA EMBL BT019768; AAV38573.1; -; mRNA EMBL AY214166; AAO21131.1; -; Genomic_DNA EMBL AK312883; BAG35731.1; -; mRNA EMBL AC103819; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471060; EAW92098.1; -; Genomic_DNA EMBL BC000141; AAH00141.2; -; mRNA EMBL BC000917; AAH00917.2; -; mRNA EMBL BC058901; AAH58901.2; -; mRNA EMBL M13929; AAA88092.1; -; mRNA IPI IPI00033016; -; . IPI IPI00935431; -; . PIR A01349; TVHUM; . PIR A01350; TVHUT; . RefSeq NP_002458.2; NM_002467.4; . UniGene Hs.202453; -; . PDB 1A93; NMR; -; A=406-434 PDB 1EE4; X-ray; 2.10 A; C/D/E/F=320-328 PDB 1MV0; NMR; -; A=55-68 PDB 1NKP; X-ray; 1.80 A; A/D=353-434 PDB 2A93; NMR; -; A=406-434 PDBsum 1A93; -; . PDBsum 1EE4; -; . PDBsum 1MV0; -; . PDBsum 1NKP; -; . PDBsum 2A93; -; . ProteinModelPortal P01106; -; . SMR P01106; 353-434; . DisProt DP00260; -; . DIP DIP-28143N; -; . IntAct P01106; 642; . MINT MINT-257327; -; . STRING P01106; -; . GlycoSuiteDB P01106; -; . PhosphoSite P01106; -; . SWISS-2DPAGE P01106; -; . PRIDE P01106; -; . Ensembl ENST00000377970; ENSP00000367207; ENSG00000136997; . GeneID 4609; -; . KEGG hsa:4609; -; . CTD 4609; -; . GeneCards GC08P124069; -; . H-InvDB HIX0007784; -; . HGNC HGNC:7553; MYC; . HPA CAB000084; -; . HPA CAB010307; -; . MIM 113970; phenotype; . MIM 190080; gene; . neXtProt NX_P01106; -; . Orphanet 543; Burkitt lymphoma; . PharmGKB PA31353; -; . eggNOG prNOG11147; -; . HOGENOM HBG445611; -; . HOVERGEN HBG000472; -; . InParanoid P01106; -; . PhylomeDB P01106; -; . Pathway_Interaction_DB wnt_canonical_pathway; Canonical Wnt signaling pathway; . Pathway_Interaction_DB ceramidepathway; Ceramide signaling pathway; . Pathway_Interaction_DB foxm1pathway; FOXM1 transcription factor network; . Pathway_Interaction_DB il2_pi3kpathway; IL2 signaling events mediated by PI3K; . Pathway_Interaction_DB il2_stat5pathway; IL2 signaling events mediated by STAT5; . Pathway_Interaction_DB il2_1pathway; IL2-mediated signaling events; . Pathway_Interaction_DB il6_7pathway; IL6-mediated signaling events; . Pathway_Interaction_DB pdgfrbpathway; PDGFR-beta signaling pathway; . Pathway_Interaction_DB ps1pathway; Presenilin action in Notch and Wnt signaling; . Pathway_Interaction_DB smad2_3nuclearpathway; Regulation of nuclear SMAD2/3 signaling; . Pathway_Interaction_DB telomerasepathway; Regulation of Telomerase; . NextBio 17740; -; . ArrayExpress P01106; -; . Bgee P01106; -; . CleanEx HS_MYC; -; . Genevestigator P01106; -; . GermOnline ENSG00000136997; Homo sapiens; . GO GO:0005730; C:nucleolus; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; IDA:UniProtKB; . GO GO:0070888; F:E-box binding; IDA:UniProtKB; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc; . GO GO:0001658; P:branching involved in ureteric bud morphogenesis; ISS:UniProtKB; . GO GO:0007050; P:cell cycle arrest; TAS:ProtInc; . GO GO:0008283; P:cell proliferation; TAS:ProtInc; . GO GO:0006879; P:cellular iron ion homeostasis; TAS:ProtInc; . GO GO:0090096; P:positive regulation of metanephric cap mesenchymal cell proliferation; ISS:UniProtKB; . GO GO:0045893; P:positive regulation of transcription; DNA-dependent; IDA:UniProtKB GO GO:0032204; P:regulation of telomere maintenance; IMP:BHF-UCL; . GO GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc; . GO GO:0042493; P:response to drug; IEP:UniProtKB; . InterPro IPR011598; HLH_DNA-bd; . InterPro IPR003327; Myc-LZ; . InterPro IPR002418; Tscrpt_reg_Myc; . InterPro IPR012682; Tscrpt_reg_Myc_N; . Gene3D G3DSA:4.10.280.10; HLH_DNA_bd; 1; . Pfam PF00010; HLH; 1; . Pfam PF02344; Myc-LZ; 1; . Pfam PF01056; Myc_N; 1; . PIRSF PIRSF001705; Myc_protein; 1; . PRINTS PR00044; LEUZIPPRMYC; . SMART SM00353; HLH; 1; . SUPFAM SSF47459; HLH_basic; 1; . PROSITE PS50888; HLH; 1; . SWISS-2DPAGE (search AC)