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SWISS-2DPAGE

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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P09874




SWISS-2DPAGE:  P09874


P09874


General information about the entry
View entry in simple text format
Entry namePARP1_HUMAN
Primary accession numberP09874
integrated into SWISS-2DPAGE on November 9, 2001 (release 15)
2D Annotations were last modified onMay 15, 2003 (version 1)
General Annotations were last modified on May 19, 2011 (version 7)
Name and origin of the protein
DescriptionRecName: Full=Poly [ADP-ribose] polymerase 1; Short=PARP-1; EC=2.4.2.30; AltName: Full=NAD(+) ADP-ribosyltransferase 1; Short=ADPRT 1; AltName: Full=Poly[ADP-ribose] synthase 1;.
Gene nameName=PARP1
Synonyms=ADPRT, PPOL
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
PubMed=12429849; [NCBI, Expasy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEOLI_HELA_1D_HUMAN {SDS-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
NUCLEOLI_HELA_1D_HUMAN
  map experimental info
  protein estimated location
 
NUCLEOLI_HELA_1D_HUMAN

MAP LOCATIONS:
Mw=101482  [identification data]

MAPPING (identification):
Tandem mass spectrometry [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
UniProtKB/Swiss-ProtP09874; PARP1_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry namePARP1_HUMAN
Primary accession numberP09874
Secondary accession number(s) B1ANJ4 Q8IUZ9
Sequence was last modified on January 23, 2007 (version 4)
Annotations were last modified on October 19, 2011 (version 155)
Name and origin of the protein
DescriptionRecName: Full=Poly [ADP-ribose] polymerase 1; Short=PARP-1; EC=2.4.2.30; AltName: Full=NAD(+) ADP-ribosyltransferase 1; Short=ADPRT 1; AltName: Full=Poly[ADP-ribose] synthase 1;
Gene nameName=PARP1
Synonyms=ADPRT, PPOL
Encoded onName=PARP1; Synonyms=ADPRT, PPOL
Keywords3D-structure; Acetylation; ADP-ribosylation; Complete proteome; Direct protein sequencing; DNA damage; DNA repair; DNA-binding; Glycosyltransferase; Metal-binding; NAD; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; S-nitrosylation; Transcription; Transcription regulation; Transferase; Zinc; Zinc-finger.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM18112; AAA60137.1; -; mRNA
EMBLJ03473; AAB59447.1; -; mRNA
EMBLM32721; AAA60155.1; -; mRNA
EMBLM29786; AAA51663.1; -; Genomic_DNA
EMBLM29545; AAA51663.1; JOINED; Genomic_DNA
EMBLM29766; AAA51663.1; JOINED; Genomic_DNA
EMBLM29767; AAA51663.1; JOINED; Genomic_DNA
EMBLM29768; AAA51663.1; JOINED; Genomic_DNA
EMBLM29769; AAA51663.1; JOINED; Genomic_DNA
EMBLM29770; AAA51663.1; JOINED; Genomic_DNA
EMBLM29771; AAA51663.1; JOINED; Genomic_DNA
EMBLM29772; AAA51663.1; JOINED; Genomic_DNA
EMBLM29773; AAA51663.1; JOINED; Genomic_DNA
EMBLM29774; AAA51663.1; JOINED; Genomic_DNA
EMBLM29775; AAA51663.1; JOINED; Genomic_DNA
EMBLM29776; AAA51663.1; JOINED; Genomic_DNA
EMBLM29777; AAA51663.1; JOINED; Genomic_DNA
EMBLM29778; AAA51663.1; JOINED; Genomic_DNA
EMBLM29779; AAA51663.1; JOINED; Genomic_DNA
EMBLM29780; AAA51663.1; JOINED; Genomic_DNA
EMBLM29781; AAA51663.1; JOINED; Genomic_DNA
EMBLM29783; AAA51663.1; JOINED; Genomic_DNA
EMBLM29784; AAA51663.1; JOINED; Genomic_DNA
EMBLM29785; AAA51663.1; JOINED; Genomic_DNA
EMBLM29544; AAA51663.1; JOINED; Genomic_DNA
EMBLM29782; AAA51663.1; JOINED; Genomic_DNA
EMBLAF524947; AAM75364.1; -; Genomic_DNA
EMBLAL359704; CAH70215.1; -; Genomic_DNA
EMBLAL359742; CAH70215.1; JOINED; Genomic_DNA
EMBLAL359742; CAI12102.1; -; Genomic_DNA
EMBLAL359704; CAI12102.1; JOINED; Genomic_DNA
EMBLCH471098; EAW69783.1; -; Genomic_DNA
EMBLBC037545; AAH37545.1; -; mRNA
EMBLX56140; CAA39606.1; -; Genomic_DNA
EMBLX56141; CAA39606.1; JOINED; Genomic_DNA
EMBLX16674; CAA34663.1; -; Genomic_DNA
EMBLM60436; AAA60000.1; -; Genomic_DNA
EMBLM17081; AAA51599.1; ALT_SEQ; mRNA
IPIIPI00449049; -; .
PIRA29725; A29725; .
RefSeqNP_001609.2; NM_001618.3; .
UniGeneHs.177766; -; .
PDB1UK0; X-ray; 3.00 A; A/B=662-1010
PDB1UK1; X-ray; 3.00 A; A/B=662-1010
PDB1WOK; X-ray; 3.00 A; A/B/C/D=662-1010
PDB2COK; NMR; -; A=387-486
PDB2CR9; NMR; -; A=518-643
PDB2CS2; NMR; -; A=103-224
PDB2DMJ; NMR; -; A=1-93
PDB2JVN; NMR; -; A=233-358
PDB2L30; NMR; -; A=1-108
PDB2L31; NMR; -; A=103-214
PDB2RCW; X-ray; 2.80 A; A=662-1011
PDB2RD6; X-ray; 2.30 A; A=662-1011
PDB2RIQ; X-ray; 1.70 A; A=216-366
PDB3GJW; X-ray; 2.30 A; A=662-1011
PDB3GN7; X-ray; 2.50 A; A=662-1011
PDB3L3L; X-ray; 2.50 A; A=662-1011
PDB3L3M; X-ray; 2.50 A; A=662-1011
PDB3OD8; X-ray; 2.40 A; A/B/C/D/E/F/G/H=1-96
PDB3ODA; X-ray; 2.64 A; A/B/C/D/E/F/G/H=1-96
PDB3ODC; X-ray; 2.80 A; A/B=105-206
PDB3ODE; X-ray; 2.95 A; A/B=105-206
PDBsum1UK0; -; .
PDBsum1UK1; -; .
PDBsum1WOK; -; .
PDBsum2COK; -; .
PDBsum2CR9; -; .
PDBsum2CS2; -; .
PDBsum2DMJ; -; .
PDBsum2JVN; -; .
PDBsum2L30; -; .
PDBsum2L31; -; .
PDBsum2RCW; -; .
PDBsum2RD6; -; .
PDBsum2RIQ; -; .
PDBsum3GJW; -; .
PDBsum3GN7; -; .
PDBsum3L3L; -; .
PDBsum3L3M; -; .
PDBsum3OD8; -; .
PDBsum3ODA; -; .
PDBsum3ODC; -; .
PDBsum3ODE; -; .
ProteinModelPortalP09874; -; .
SMRP09874; 1-359; 381-489; 520-643
662-1011.
DIPDIP-38N; -; .
IntActP09874; 29; .
MINTMINT-104344; -; .
STRINGP09874; -; .
PhosphoSiteP09874; -; .
SWISS-2DPAGEP09874; -; .
Aarhus/Ghent-2DPAGE1620; NEPHGE; .
PeptideAtlasP09874; -; .
PRIDEP09874; -; .
EnsemblENST00000366794; ENSP00000355759; ENSG00000143799; .
GeneID142; -; .
KEGGhsa:142; -; .
UCSCuc001hqd.2; human; .
CTD142; -; .
GeneCardsGC01M197065; -; .
H-InvDBHIX0023551; -; .
HGNCHGNC:270; PARP1; .
HPACAB000147; -; .
HPACAB003839; -; .
HPACAB003840; -; .
MIM173870; gene; .
neXtProtNX_P09874; -; .
PharmGKBPA32; -; .
eggNOGprNOG14412; -; .
HOGENOMHBG356841; -; .
HOVERGENHBG053513; -; .
InParanoidP09874; -; .
OMAEYSASQL; -; .
OrthoDBEOG4PG609; -; .
PhylomeDBP09874; -; .
BRENDA2.4.2.30; 2681; .
Pathway_Interaction_DBcaspase_pathway; Caspase cascade in apoptosis; .
Pathway_Interaction_DBfaspathway; FAS signaling pathway (CD95); .
NextBio565; -; .
PMAP-CutDBP09874; -; .
ArrayExpressP09874; -; .
BgeeP09874; -; .
CleanExHS_PARP1; -; .
GenevestigatorP09874; -; .
GermOnlineENSG00000143799; Homo sapiens; .
GOGO:0005635; C:nuclear envelope; IDA:UniProtKB; .
GOGO:0005730; C:nucleolus; IDA:UniProtKB; .
GOGO:0005667; C:transcription factor complex; IDA:BHF-UCL; .
GOGO:0003677; F:DNA binding; TAS:ProtInc; .
GOGO:0003950; F:NAD+ ADP-ribosyltransferase activity; IDA:UniProtKB; .
GOGO:0047485; F:protein N-terminus binding; IPI:UniProtKB; .
GOGO:0008134; F:transcription factor binding; IPI:BHF-UCL; .
GOGO:0008270; F:zinc ion binding; IEA:InterPro; .
GOGO:0032869; P:cellular response to insulin stimulus; IDA:BHF-UCL; .
GOGO:0006281; P:DNA repair; TAS:UniProtKB; .
GOGO:0006471; P:protein ADP-ribosylation; IDA:UniProtKB; .
GOGO:0006355; P:regulation of transcription; DNA-dependent; IEA:UniProtKB-KW
GOGO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc; .
InterProIPR001357; BRCT; .
InterProIPR008288; NAD_ADPRT; .
InterProIPR012982; PADR1; .
InterProIPR012317; Poly(ADP-ribose)pol_cat_dom; .
InterProIPR004102; Poly(ADP-ribose)pol_reg_dom; .
InterProIPR008893; WGR_domain; .
InterProIPR001510; Znf_PARP; .
Gene3DG3DSA:2.20.140.10; G3DSA:2.20.140.10; 1; .
Gene3DG3DSA:1.20.142.10; PARP_reg; 1; .
Gene3DG3DSA:3.30.1740.10; Znf_PARP; 2; .
PfamPF00533; BRCT; 1; .
PfamPF08063; PADR1; 1; .
PfamPF00644; PARP; 1; .
PfamPF02877; PARP_reg; 1; .
PfamPF05406; WGR; 1; .
PfamPF00645; zf-PARP; 2; .
PIRSFPIRSF000489; NAD_ADPRT; 1; .
SMARTSM00292; BRCT; 1; .
SMARTSM00773; WGR; 1; .
SUPFAMSSF52113; BRCT; 1; .
SUPFAMSSF47587; PARP_reg; 1; .
SUPFAMSSF142921; SSF142921; 1; .
PROSITEPS50172; BRCT; 1; .
PROSITEPS51060; PARP_ALPHA_HD; 1; .
PROSITEPS51059; PARP_CATALYTIC; 1; .
PROSITEPS00347; PARP_ZN_FINGER_1; 2; .
PROSITEPS50064; PARP_ZN_FINGER_2; 2; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server