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SWISS-2DPAGE

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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P13010




SWISS-2DPAGE:  P13010


P13010


General information about the entry
View entry in simple text format
Entry nameXRCC5_HUMAN
Primary accession numberP13010
integrated into SWISS-2DPAGE on May 15, 2003 (release 16)
2D Annotations were last modified onMay 15, 2003 (version 1)
General Annotations were last modified on May 19, 2011 (version 6)
Name and origin of the protein
DescriptionRecName: Full=X-ray repair cross-complementing protein 5; EC=3.6.4.-; AltName: Full=86 kDa subunit of Ku antigen; AltName: Full=ATP-dependent DNA helicase 2 subunit 2; AltName: Full=ATP-dependent DNA helicase II 80 kDa subunit; AltName: Full=CTC box-binding factor 85 kDa subunit; Short=CTC85; Short=CTCBF; AltName: Full=DNA repair protein XRCC5; AltName: Full=Ku80; AltName: Full=Ku86; AltName: Full=Lupus Ku autoantigen protein p86; AltName: Full=Nuclear factor IV; AltName: Full=Thyroid-lupus autoantigen; Short=TLAA; AltName: Full=X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining);.
Gene nameName=XRCC5
Synonyms=G22P2
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
PubMed=12429849; [NCBI, Expasy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
Comments
  • SUBUNIT: HETERODIMER OF A 70 kDa AND A 80 kDa SUBUNIT
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEOLI_HELA_1D_HUMAN {SDS-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
NUCLEOLI_HELA_1D_HUMAN
  map experimental info
  protein estimated location
 
NUCLEOLI_HELA_1D_HUMAN

MAP LOCATIONS:
Mw=82958  [identification data]

MAPPING (identification):
Tandem mass spectrometry [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
UniProtKB/Swiss-ProtP13010; XRCC5_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameXRCC5_HUMAN
Primary accession numberP13010
Secondary accession number(s) A8K3X5 Q0Z7V0 Q4VBQ5 Q53HH7 Q7M4N0 Q9UCQ0 Q9UCQ1
Sequence was last modified on January 23, 2007 (version 3)
Annotations were last modified on October 19, 2011 (version 139)
Name and origin of the protein
DescriptionRecName: Full=X-ray repair cross-complementing protein 5; EC=3.6.4.-; AltName: Full=86 kDa subunit of Ku antigen; AltName: Full=ATP-dependent DNA helicase 2 subunit 2; AltName: Full=ATP-dependent DNA helicase II 80 kDa subunit; AltName: Full=CTC box-binding factor 85 kDa subunit; Short=CTC85; Short=CTCBF; AltName: Full=DNA repair protein XRCC5; AltName: Full=Ku80; AltName: Full=Ku86; AltName: Full=Lupus Ku autoantigen protein p86; AltName: Full=Nuclear factor IV; AltName: Full=Thyroid-lupus autoantigen; Short=TLAA; AltName: Full=X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining);
Gene nameName=XRCC5
Synonyms=G22P2
Encoded onName=XRCC5; Synonyms=G22P2
Keywords3D-structure; Acetylation; Activator; ATP-binding; Chromosome; Complete proteome; Direct protein sequencing; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Systemic lupus erythematosus; Transcription; Transcription regulation; Ubl conjugation.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLJ04977; AAA59475.1; -; mRNA
EMBLM30938; AAA36154.1; -; mRNA
EMBLAK290740; BAF83429.1; -; mRNA
EMBLAK222603; BAD96323.1; -; mRNA
EMBLDQ787434; ABG46942.1; -; Genomic_DNA
EMBLCH471063; EAW70562.1; -; Genomic_DNA
EMBLBC019027; AAH19027.1; -; mRNA
EMBLBC095442; AAH95442.1; -; mRNA
EMBLX57500; CAA40736.1; -; mRNA
IPIIPI00220834; -; .
PIRA35051; A32626; .
PIRD42397; D42397; .
PIRS62889; S62889; .
RefSeqNP_066964.1; NM_021141.3; .
UniGeneHs.388739; -; .
PDB1JEQ; X-ray; 2.70 A; B=1-565
PDB1JEY; X-ray; 2.50 A; B=1-565
PDB1Q2Z; NMR; -; A=592-708
PDB1RW2; NMR; -; A=566-709
PDB3RZ9; X-ray; 2.29 A; B=559-571
PDBsum1JEQ; -; .
PDBsum1JEY; -; .
PDBsum1Q2Z; -; .
PDBsum1RW2; -; .
PDBsum3RZ9; -; .
ProteinModelPortalP13010; -; .
SMRP13010; 6-545; 566-710; .
DIPDIP-31379N; -; .
IntActP13010; 24; .
MINTMINT-131739; -; .
STRINGP13010; -; .
PhosphoSiteP13010; -; .
SWISS-2DPAGEP13010; -; .
PRIDEP13010; -; .
EnsemblENST00000328063; ENSP00000329528; ENSG00000079246; .
EnsemblENST00000392132; ENSP00000375977; ENSG00000079246; .
EnsemblENST00000392133; ENSP00000375978; ENSG00000079246; .
GeneID7520; -; .
KEGGhsa:7520; -; .
UCSCuc002vfy.1; human; .
CTD7520; -; .
GeneCardsGC02P208831; -; .
H-InvDBHIX0002808; -; .
HGNCHGNC:12833; XRCC5; .
HPACAB004468; -; .
HPAHPA025813; -; .
MIM194364; gene; .
neXtProtNX_P13010; -; .
PharmGKBPA37425; -; .
eggNOGprNOG19702; -; .
HOVERGENHBG006237; -; .
InParanoidP13010; -; .
OMALDEIYSF; -; .
OrthoDBEOG4NZTSV; -; .
PhylomeDBP13010; -; .
Pathway_Interaction_DBbard1pathway; BARD1 signaling events; .
Pathway_Interaction_DBar_pathway; Coregulation of Androgen receptor activity; .
Pathway_Interaction_DBtelomerasepathway; Regulation of Telomerase; .
ReactomeREACT_216; DNA Repair; .
ReactomeREACT_6185; HIV Infection; .
NextBio29431; -; .
PMAP-CutDBP13010; -; .
ArrayExpressP13010; -; .
BgeeP13010; -; .
CleanExHS_XRCC5; -; .
GenevestigatorP13010; -; .
GermOnlineENSG00000079246; Homo sapiens; .
GOGO:0005958; C:DNA-dependent protein kinase-DNA ligase 4 complex; IEA:InterPro; .
GOGO:0043564; C:Ku70:Ku80 complex; IDA:UniProtKB; .
GOGO:0000783; C:nuclear telomere cap complex; TAS:BHF-UCL; .
GOGO:0005654; C:nucleoplasm; TAS:Reactome; .
GOGO:0005524; F:ATP binding; IEA:UniProtKB-KW; .
GOGO:0004003; F:ATP-dependent DNA helicase activity; TAS:ProtInc; .
GOGO:0003690; F:double-stranded DNA binding; TAS:ProtInc; .
GOGO:0008022; F:protein C-terminus binding; IPI:UniProtKB; .
GOGO:0042162; F:telomeric DNA binding; IDA:BHF-UCL; .
GOGO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL; .
GOGO:0006303; P:double-strand break repair via nonhomologous end joining; IMP:UniProtKB; .
GOGO:0019059; P:initiation of viral infection; TAS:Reactome; .
GOGO:0045892; P:negative regulation of transcription; DNA-dependent; IMP:UniProtKB
GOGO:0019047; P:provirus integration; TAS:Reactome; .
GOGO:0000723; P:telomere maintenance; TAS:BHF-UCL; .
GOGO:0006351; P:transcription; DNA-dependent; IEA:UniProtKB-KW
InterProIPR006164; DNA_helicase_ATP-dep_Ku; .
InterProIPR024193; DNA_helicase_ATP-dep_Ku80; .
InterProIPR005160; Ku_C; .
InterProIPR005161; Ku_N; .
InterProIPR014893; Ku_PK_bind; .
InterProIPR016194; SPOC-like; .
InterProIPR002035; VWF_A; .
Gene3DG3DSA:2.40.290.10; G3DSA:2.40.290.10; 1; .
Gene3DG3DSA:1.10.1600.10; Ku_C; 1; .
Gene3DG3DSA:1.25.40.240; Ku_PK_bind; 1; .
PfamPF02735; Ku; 1; .
PfamPF03730; Ku_C; 1; .
PfamPF03731; Ku_N; 1; .
PfamPF08785; Ku_PK_bind; 1; .
PIRSFPIRSF016570; Ku80; 1; .
SMARTSM00559; Ku78; 1; .
SMARTSM00327; VWA; 1; .
SUPFAMSSF101420; Ku_PK_bind; 1; .
SUPFAMSSF100939; SPOC-like; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server