Attention: World-2DPAGE is no longer maintained.

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

References

[1]	MAPPING ON GEL PubMed=12429849; [NCBI, Expasy, EBI, Israel, Japan] Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J. ''''''Functional proteomic analysis of human nucleolus'';'';'' Mol. Biol. Cell. 13(1):4100-4109(2002)

Comments

SUBUNIT: SIGNAL RECOGNITION PARTICLE CONSISTS OF A 7S RNA MOLECULE OF 300 NUCLEOTIDES AND SIX PROTEIN SUBUNITS: SRP72, SRP68, SRP54, SRP19, SRP14 AND SRP9

2D PAGE maps for identified proteins

How to interpret a protein

NUCLEOLI_HELA_1D_HUMAN {SDS-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma

map experimental info
protein estimated location

NUCLEOLI_HELA_1D_HUMAN

MAP LOCATIONS:

BAND 1D-001VA7:

Mw=19877

[identification data]

BAND 1D-001VA8:

Mw=19520

[identification data]

MAPPING (identification):
Tandem mass spectrometry [1].

Copyright

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).

Cross-references

UniProtKB/Swiss-Prot

P37108; SRP14_HUMAN.

2D PAGE maps for identified proteins

How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry name	SRP14_HUMAN
Primary accession number	P37108
Secondary accession number(s)	B5BUF5 Q6B0K5 Q96Q14
Sequence was last modified on	October 17, 2006 (version 2)
Annotations were last modified on	October 19, 2011 (version 114)
Name and origin of the protein
Description	RecName: Full=Signal recognition particle 14 kDa protein; Short=SRP14; AltName: Full=18 kDa Alu RNA-binding protein;
Gene name	Name=SRP14
Encoded on	Name=SRP14
Keywords	3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Polymorphism; Reference proteome; Ribonucleoprotein; RNA-binding; Signal recognition particle.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL	X73459; CAA51838.1; -; mRNA
EMBL	U07857; AAA59066.1; -; mRNA
EMBL	AB061546; BAB69067.1; -; mRNA
EMBL	AB451391; BAG70205.1; -; mRNA
EMBL	AC025168; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBL	CH471125; EAW92390.1; -; Genomic_DNA
EMBL	BC035495; AAH35495.1; -; mRNA
EMBL	BC071716; AAH71716.1; -; mRNA
EMBL	BC100031; AAI00032.1; -; mRNA
IPI	IPI00293434; -; .
PIR	A56062; A56062; .
PIR	S34196; S34196; .
RefSeq	NP_003125.3; NM_003134.4; .
UniGene	Hs.533732; -; .
PDB	1E8O; X-ray; 3.20 A; B/D=2-107
PDB	1E8S; X-ray; 4.00 A; B=2-107
PDB	1RY1; EM; 12.00 A; D=2-107
PDBsum	1E8O; -; .
PDBsum	1E8S; -; .
PDBsum	1RY1; -; .
ProteinModelPortal	P37108; -; .
SMR	P37108; 2-95; .
DIP	DIP-6152N; -; .
IntAct	P37108; 4; .
MINT	MINT-1413971; -; .
STRING	P37108; -; .
TCDB	3.A.5.9.1; general secretory pathway (Sec) family; .
PhosphoSite	P37108; -; .
SWISS-2DPAGE	P37108; -; .
PeptideAtlas	P37108; -; .
PRIDE	P37108; -; .
Ensembl	ENST00000267884; ENSP00000267884; ENSG00000140319; .
GeneID	6727; -; .
KEGG	hsa:6727; -; .
UCSC	uc001zkq.2; human; .
CTD	6727; -; .
GeneCards	GC15M017172; -; .
H-InvDB	HIX0202180; -; .
HGNC	HGNC:11299; SRP14; .
MIM	600708; gene; .
neXtProt	NX_P37108; -; .
PharmGKB	PA36123; -; .
eggNOG	prNOG20599; -; .
GeneTree	ENSGT00390000008496; -; .
HOGENOM	HBG629003; -; .
HOVERGEN	HBG057435; -; .
InParanoid	P37108; -; .
OMA	PVPRKGH; -; .
OrthoDB	EOG415GG0; -; .
PhylomeDB	P37108; -; .
Reactome	REACT_15380; Diabetes pathways; .
NextBio	26240; -; .
ArrayExpress	P37108; -; .
Bgee	P37108; -; .
CleanEx	HS_SRP14; -; .
Genevestigator	P37108; -; .
GermOnline	ENSG00000140319; Homo sapiens; .
GO	GO:0005829; C:cytosol; TAS:Reactome; .
GO	GO:0005786; C:signal recognition particle; endoplasmic reticulum targeting; IDA:UniProtKB
GO	GO:0008312; F:7S RNA binding; TAS:ProtInc; .
GO	GO:0030942; F:endoplasmic reticulum signal peptide binding; IEA:InterPro; .
GO	GO:0045900; P:negative regulation of translational elongation; IEA:InterPro; .
GO	GO:0042493; P:response to drug; IDA:UniProtKB; .
GO	GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro; .
InterPro	IPR003210; Signal_recog_particle_SRP14; .
InterPro	IPR009018; Signal_recog_particle_SRP9/14; .
Gene3D	G3DSA:3.30.720.10; Signal_recog_particle_SRP9/14; 1; .
PANTHER	PTHR12013; SRP14; 1; .
Pfam	PF02290; SRP14; 1; .
ProDom	PD009170; Signal_recog_particle_SRP14; 1; .
SUPFAM	SSF54762; SRP9/14; 1; .

SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server