World-2DPAGE Home
Home  |  Contact

Attention: World-2DPAGE is no longer maintained. Previously submitted data can still be queried at World-2DPAGE Repository.


SWISS-2DPAGE 
Search by  [accession number] *
[description, ID or gene] 
[author names] 
[spot ID / serial number] 
[identification methods] 
[pI / Mw range] 
[combined fields] 

Maps  [experimental info] 
[protein list] 
[graphical interface]

     Select Remote Interfaces
[All Interfaces]
World-2DPAGE Portal
World-2DPAGE Repository

Exclude local DBs
has only effect if a remote
interface is selected
     

Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: A1AG1_HUMAN




SWISS-2DPAGE:  A1AG1_HUMAN


A1AG1_HUMAN


General information about the entry
View entry in simple text format
Entry nameA1AG1_HUMAN
Primary accession numberP02763
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onDecember 1, 2000 (version 1)
General Annotations were last modified on May 19, 2011 (version 12)
Name and origin of the protein
DescriptionRecName: Full=Alpha-1-acid glycoprotein 1; Short=AGP 1; AltName: Full=Orosomucoid-1; Short=OMD 1; Flags: Precursor;.
Gene nameName=ORM1
Synonyms=AGP1
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=78094420; PubMed=271964; [NCBI, ExPASy, EBI, Israel, Japan]
Anderson N.L., Anderson N.G.
''''''High resolution two-dimensional electrophoresis of human plasma proteins'';'';''
Proc. Natl. Acad. Sci. U.S.A. 74(1):5421-5425(1977)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
Comments
  • SUBUNIT: SINGLE CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

CSF_HUMAN {Cerebrospinal Fluid}
Homo sapiens (Human)
Tissue: Cerebrospinal fluid
CSF_HUMAN
  map experimental info
  protein estimated location
 
CSF_HUMAN

MAP LOCATIONS:
pI=3.95; Mw=47169
pI=4.09; Mw=45624
pI=4.02; Mw=44264
pI=3.98; Mw=43600

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [2].



PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=4.11; Mw=46062
pI=4.16; Mw=44950
pI=4.21; Mw=43984
pI=4.24; Mw=43865
pI=4.29; Mw=42922

NORMAL LEVEL:
550-1400 MG/L.

PATHOLOGICAL LEVEL:
DECREASED DURING NEPHROTIC SYNDROME; INCREASED DURING TISSUE DAMAGE, INFLAMMATION AND MYELOMA.

POSITIONAL VARIANTS:
FF, FS AND SS VARIANTS; SOME OTHER VARIANTS.

MAPPING (identification):
IMMUNOBLOTTING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
Siena-2DPAGEP02763; A1AG1_HUMAN.
UniProtKB/Swiss-ProtP02763; A1AG1_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameA1AG1_HUMAN
Primary accession numberP02763
Secondary accession number(s) B7ZKQ5 Q5T539 Q5U067 Q8TC16
Sequence was last modified on January 1, 1988 (version 1)
Annotations were last modified on September 21, 2011 (version 135)
Name and origin of the protein
DescriptionRecName: Full=Alpha-1-acid glycoprotein 1; Short=AGP 1; AltName: Full=Orosomucoid-1; Short=OMD 1; Flags: Precursor;
Gene nameName=ORM1
Synonyms=AGP1
Encoded onName=ORM1; Synonyms=AGP1
Keywords3D-structure; Acute phase; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Polymorphism; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal; Transport.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX02544; CAA26397.1; -; mRNA
EMBLM13692; AAA35515.1; -; mRNA
EMBLX05779; CAA29229.1; ALT_SEQ; Genomic_DNA
EMBLX05780; CAA29229.1; JOINED; Genomic_DNA
EMBLX05781; CAA29229.1; JOINED; Genomic_DNA
EMBLX05782; CAA29229.1; JOINED; Genomic_DNA
EMBLX05783; CAA29229.1; JOINED; Genomic_DNA
EMBLX05784; CAA29229.1; JOINED; Genomic_DNA
EMBLX06676; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLX06680; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLBT019790; AAV38593.1; -; mRNA
EMBLAK312035; BAG34972.1; -; mRNA
EMBLAL356796; CAI16859.1; -; Genomic_DNA
EMBLCH471090; EAW87416.1; -; Genomic_DNA
EMBLBC104818; AAI04819.1; -; mRNA
EMBLBC104820; AAI04821.1; -; mRNA
EMBLBC143313; AAI43314.1; -; mRNA
EMBLBC143314; AAI43315.1; -; mRNA
EMBLBC026238; AAH26238.1; -; mRNA
IPIIPI00022429; -; .
PIRA28346; OMHU1; .
RefSeqNP_000598.2; NM_000607.2; .
UniGeneHs.522356; -; .
PDB3KQ0; X-ray; 1.80 A; A=20-201
PDBsum3KQ0; -; .
ProteinModelPortalP02763; -; .
SMRP02763; 19-193; .
IntActP02763; 2; .
STRINGP02763; -; .
GlycoSuiteDBP02763; -; .
SWISS-2DPAGEP02763; -; .
Siena-2DPAGEP02763; -; .
PeptideAtlasP02763; -; .
PRIDEP02763; -; .
EnsemblENST00000259396; ENSP00000259396; ENSG00000229314; .
GeneID5004; -; .
KEGGhsa:5004; -; .
CTD5004; -; .
GeneCardsGC09P086691; -; .
HGNCHGNC:8498; ORM1; .
HPACAB006265; -; .
MIM138600; gene; .
neXtProtNX_P02763; -; .
PharmGKBPA260; -; .
eggNOGprNOG11781; -; .
HOGENOMHBG126438; -; .
HOVERGENHBG000035; -; .
InParanoidP02763; -; .
OrthoDBEOG4V9TS3; -; .
DrugBankDB01418; Acenocoumarol; .
DrugBankDB00802; Alfentanil; .
DrugBankDB01429; Aprindine; .
DrugBankDB00280; Disopyramide; .
DrugBankDB01359; Penbutolol; .
DrugBankDB00946; Phenprocoumon; .
DrugBankDB00908; Quinidine; .
DrugBankDB00706; Tamsulosin; .
NextBio19272; -; .
ArrayExpressP02763; -; .
BgeeP02763; -; .
CleanExHS_ORM1; -; .
GenevestigatorP02763; -; .
GermOnlineENSG00000187681; Homo sapiens; .
GOGO:0005615; C:extracellular space; TAS:ProtInc; .
GOGO:0005515; F:protein binding; IPI:IntAct; .
GOGO:0006953; P:acute-phase response; TAS:ProtInc; .
GOGO:0002682; P:regulation of immune system process; IEA:InterPro; .
GOGO:0006810; P:transport; IEA:UniProtKB-KW; .
InterProIPR001500; A1A_glycop; .
InterProIPR012674; Calycin; .
InterProIPR011038; Calycin-like; .
InterProIPR000566; Lipocln_cytosolic_FA-bd_dom; .
Gene3DG3DSA:2.40.128.20; Calycin; 1; .
PANTHERPTHR11967; A1A_glycop; 1; .
PfamPF00061; Lipocalin; 1; .
PIRSFPIRSF036899; AGP; 1; .
PRINTSPR00708; A1AGLPROTEIN; .
SUPFAMSSF50814; Calycin; 1; .
PROSITEPS00213; LIPOCALIN; FALSE_NEG; .



SWISS-2DPAGE image

SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server