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SWISS-2DPAGE

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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: A1AG2_HUMAN




SWISS-2DPAGE:  A1AG2_HUMAN


A1AG2_HUMAN


General information about the entry
View entry in simple text format
Entry nameA1AG2_HUMAN
Primary accession numberP19652
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onDecember 1, 2000 (version 1)
General Annotations were last modified on May 19, 2011 (version 11)
Name and origin of the protein
DescriptionRecName: Full=Alpha-1-acid glycoprotein 2; Short=AGP 2; AltName: Full=Orosomucoid-2; Short=OMD 2; Flags: Precursor;.
Gene nameName=ORM2
Synonyms=AGP2
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=78094420; PubMed=271964; [NCBI, Expasy, EBI, Israel, Japan]
Anderson N.L., Anderson N.G.
''''''High resolution two-dimensional electrophoresis of human plasma proteins'';'';''
Proc. Natl. Acad. Sci. U.S.A. 74(1):5421-5425(1977)
Comments
  • SUBUNIT: SINGLE CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=4.11; Mw=46062
pI=4.16; Mw=44950
pI=4.21; Mw=43984
pI=4.24; Mw=43865
pI=4.29; Mw=42922

NORMAL LEVEL:
550-1400 MG/L [1].

PATHOLOGICAL LEVEL:
DECREASED DURING NEPHROTIC SYNDROME [1]; INCREASED DURING TISSUE DAMAGE, INFLAMMATION AND MYELOMA [1].

POSITIONAL VARIANTS:
FF, FS AND SS VARIANTS [1]; SOME OTHER VARIANTS [1].

MAPPING (identification):
MICROSEQUENCING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
DOSAC-COBS 2D-PAGEP19652; P19652.
DOSAC-COBS-2DPAGEP19652; A1AG2_HUMAN.
UniProtKB/Swiss-ProtP19652; A1AG2_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameA1AG2_HUMAN
Primary accession numberP19652
Secondary accession number(s) B2R5L2 Q16571 Q5T538 Q6IB74
Sequence was last modified on April 1, 1993 (version 2)
Annotations were last modified on September 21, 2011 (version 126)
Name and origin of the protein
DescriptionRecName: Full=Alpha-1-acid glycoprotein 2; Short=AGP 2; AltName: Full=Orosomucoid-2; Short=OMD 2; Flags: Precursor;
Gene nameName=ORM2
Synonyms=AGP2
Encoded onName=ORM2; Synonyms=AGP2
Keywords3D-structure; Acute phase; Complete proteome; Disulfide bond; Glycoprotein; Polymorphism; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal; Transport.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX06675; CAA29874.1; ALT_SEQ; Genomic_DNA
EMBLX05780; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLX06674; CAA29873.2; ALT_SEQ; Genomic_DNA
EMBLX06676; CAA29873.2; JOINED; Genomic_DNA
EMBLX06677; CAA29873.2; JOINED; Genomic_DNA
EMBLX06678; CAA29873.2; JOINED; Genomic_DNA
EMBLX06679; CAA29873.2; JOINED; Genomic_DNA
EMBLX06680; CAA29873.2; JOINED; Genomic_DNA
EMBLX05784; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLM21540; AAA51549.1; -; Genomic_DNA
EMBLAK312226; BAG35159.1; -; mRNA
EMBLCR456930; CAG33211.1; -; mRNA
EMBLAL356796; CAI16860.1; -; Genomic_DNA
EMBLCH471090; EAW87417.1; -; Genomic_DNA
EMBLBC015964; AAH15964.1; -; mRNA
EMBLBC056239; AAH56239.1; -; mRNA
IPIIPI00020091; -; .
PIRJT0326; OMHU2; .
RefSeqNP_000599.1; NM_000608.2; .
UniGeneHs.719954; -; .
PDB3APU; X-ray; 2.10 A; A/B=19-201
PDB3APV; X-ray; 2.15 A; A/B=19-201
PDB3APW; X-ray; 2.20 A; A/B=19-201
PDB3APX; X-ray; 2.20 A; A=19-201
PDBsum3APU; -; .
PDBsum3APV; -; .
PDBsum3APW; -; .
PDBsum3APX; -; .
ProteinModelPortalP19652; -; .
SMRP19652; 19-196; .
STRINGP19652; -; .
GlycoSuiteDBP19652; -; .
SWISS-2DPAGEP19652; -; .
DOSAC-COBS-2DPAGEP19652; -; .
PeptideAtlasP19652; -; .
PRIDEP19652; -; .
EnsemblENST00000431067; ENSP00000394936; ENSG00000228278; .
GeneID5005; -; .
KEGGhsa:5005; -; .
UCSCuc004bil.1; human; .
CTD5005; -; .
GeneCardsGC09P086697; -; .
HGNCHGNC:8499; ORM2; .
MIM138610; gene; .
neXtProtNX_P19652; -; .
PharmGKBPA32818; -; .
eggNOGprNOG11781; -; .
HOGENOMHBG126438; -; .
HOVERGENHBG000035; -; .
InParanoidP19652; -; .
OMAFYIASAS; -; .
OrthoDBEOG4V9TS3; -; .
NextBio19276; -; .
ArrayExpressP19652; -; .
BgeeP19652; -; .
GenevestigatorP19652; -; .
GermOnlineENSG00000204154; Homo sapiens; .
GOGO:0005615; C:extracellular space; TAS:ProtInc; .
GOGO:0005488; F:binding; IEA:InterPro; .
GOGO:0006953; P:acute-phase response; TAS:ProtInc; .
GOGO:0002682; P:regulation of immune system process; IEA:InterPro; .
GOGO:0006810; P:transport; IEA:UniProtKB-KW; .
InterProIPR001500; A1A_glycop; .
InterProIPR012674; Calycin; .
InterProIPR011038; Calycin-like; .
InterProIPR000566; Lipocln_cytosolic_FA-bd_dom; .
Gene3DG3DSA:2.40.128.20; Calycin; 1; .
PANTHERPTHR11967; A1A_glycop; 1; .
PfamPF00061; Lipocalin; 1; .
PIRSFPIRSF036899; AGP; 1; .
PRINTSPR00708; A1AGLPROTEIN; .
SUPFAMSSF50814; Calycin; 1; .
PROSITEPS00213; LIPOCALIN; FALSE_NEG; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server