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SWISS-2DPAGE

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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: ACOC_MOUSE




SWISS-2DPAGE:  ACOC_MOUSE


ACOC_MOUSE


General information about the entry
View entry in simple text format
Entry nameACOC_MOUSE
Primary accession numberP28271
integrated into SWISS-2DPAGE on June 30, 1999 (release 10)
2D Annotations were last modified onOctober 1, 2001 (version 2)
General Annotations were last modified on May 19, 2011 (version 8)
Name and origin of the protein
DescriptionRecName: Full=Cytoplasmic aconitate hydratase; Short=Aconitase; EC=4.2.1.3; AltName: Full=Citrate hydro-lyase; AltName: Full=Iron regulatory protein 1; Short=IRP1; AltName: Full=Iron-responsive element-binding protein 1; Short=IRE-BP 1;.
Gene nameName=Aco1
Synonyms=Ireb1, Irebp
Annotated speciesMus musculus (Mouse) [TaxID: 10090]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus.
References
[1]   MAPPING ON GEL
PubMed=11680894; [NCBI, Expasy, EBI, Israel, Japan]
Sanchez J.-C., Chiappe D., Converset V., Hoogland C., Binz P.-A., Paesano S., Appel R.D., Wang S., Sennitt M., Nolan A., Cawthorne M.A., Hochstrasser D.F.
''''''The mouse SWISS-2DPAGE database: a tool for proteomics study of diabetes and obesity'';'';''
Proteomics 1(1):136-163(2001)
2D PAGE maps for identified proteins
How to interpret a protein

LIVER_MOUSE {Liver}
Mus musculus (Mouse)
Tissue: Liver
LIVER_MOUSE
  map experimental info
  protein estimated location
 
LIVER_MOUSE

MAP LOCATIONS:
pI=6.75; Mw=99501  [identification data]
pI=6.68; Mw=99501  [identification data]
pI=6.90; Mw=89040  [identification data]
pI=6.84; Mw=89040  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
REPRODUCTION-2DPAGEP28271; P28271.
UniProtKB/Swiss-ProtP28271; ACOC_MOUSE.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameACOC_MOUSE
Primary accession numberP28271
Secondary accession number(s) Q3TQ15 Q99K54
Sequence was last modified on July 27, 2011 (version 3)
Annotations were last modified on October 19, 2011 (version 109)
Name and origin of the protein
DescriptionRecName: Full=Cytoplasmic aconitate hydratase; Short=Aconitase; EC=4.2.1.3; AltName: Full=Citrate hydro-lyase; AltName: Full=Iron regulatory protein 1; Short=IRP1; AltName: Full=Iron-responsive element-binding protein 1; Short=IRE-BP 1;
Gene nameName=Aco1
Synonyms=Ireb1, Irebp
Encoded onName=Aco1; Synonyms=Ireb1, Irebp
Keywords4Fe-4S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome; RNA-binding; Tricarboxylic acid cycle.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX61147; CAA43455.1; -; mRNA
EMBLAK163985; BAE37570.1; -; mRNA
EMBLAL831793; CAM27573.1; -; Genomic_DNA
EMBLCH466538; EDL05446.1; -; Genomic_DNA
EMBLBC005454; AAH05454.1; -; mRNA
IPIIPI00875325; -; .
PIRS18720; S18720; .
RefSeqNP_031412.2; NM_007386.2; .
UniGeneMm.331547; -; .
ProteinModelPortalP28271; -; .
STRINGP28271; -; .
PhosphoSiteP28271; -; .
SWISS-2DPAGEP28271; -; .
REPRODUCTION-2DPAGEP28271; -; .
PRIDEP28271; -; .
EnsemblENSMUST00000102973; ENSMUSP00000100038; ENSMUSG00000028405; .
GeneID11428; -; .
MGIMGI:87879; Aco1; .
eggNOGroNOG06028; -; .
GeneTreeENSGT00530000063060; -; .
HOVERGENHBG052147; -; .
OrthoDBEOG4C2H8W; -; .
NextBio278700; -; .
ArrayExpressP28271; -; .
BgeeP28271; -; .
CleanExMM_ACO1; -; .
GenevestigatorP28271; -; .
GermOnlineENSMUSG00000028405; Mus musculus; .
GOGO:0005829; C:cytosol; IDA:MGI; .
GOGO:0005739; C:mitochondrion; IDA:MGI; .
GOGO:0051539; F:4 iron; 4 sulfur cluster binding; ISS:UniProtKB
GOGO:0003994; F:aconitate hydratase activity; ISS:UniProtKB; .
GOGO:0052632; F:citrate hydro-lyase (cis-aconitate-forming) activity; IEA:EC; .
GOGO:0030350; F:iron-responsive element binding; ISS:UniProtKB; .
GOGO:0052633; F:isocitrate hydro-lyase (cis-aconitate-forming) activity; IEA:EC; .
GOGO:0046872; F:metal ion binding; IEA:UniProtKB-KW; .
GOGO:0006879; P:cellular iron ion homeostasis; IMP:MGI; .
GOGO:0006101; P:citrate metabolic process; ISS:UniProtKB; .
GOGO:0050892; P:intestinal absorption; IGI:MGI; .
GOGO:0009791; P:post-embryonic development; IGI:MGI; .
GOGO:0006417; P:regulation of translation; IMP:MGI; .
GOGO:0010040; P:response to iron(II) ion; ISS:UniProtKB; .
GOGO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW; .
InterProIPR015931; Acnase/IPM_dHydase_lsu_aba_1/3; .
InterProIPR015937; Acoase/IPM_deHydtase; .
InterProIPR001030; Acoase/IPM_deHydtase_lsu_aba; .
InterProIPR015928; Aconitase/3IPM_dehydase_swvl; .
InterProIPR006249; Aconitase/Fe_reg_prot_2; .
InterProIPR015934; Aconitase/Fe_reg_prot_2/AcnD; .
InterProIPR015932; Aconitase/IPMdHydase_lsu_aba_2; .
InterProIPR018136; Aconitase_4Fe-4S_BS; .
InterProIPR000573; AconitaseA/IPMdHydase_ssu_swvl; .
Gene3DG3DSA:3.30.499.10; Acnase/IPM_dHydase_lsu_aba_1/3; 3; .
Gene3DG3DSA:3.20.19.10; Aconitase/3IPM_dehydase_swvl; 1; .
Gene3DG3DSA:3.40.1060.10; Aconitase/IPMdHydase_lsu_aba_2; 1; .
PANTHERPTHR11670; Aconitase-like_core; 1; .
PANTHERPTHR11670:SF1; Aconitase/Fe_reg_prot_2/AcnD; 1; .
PfamPF00330; Aconitase; 1; .
PfamPF00694; Aconitase_C; 1; .
PRINTSPR00415; ACONITASE; .
SUPFAMSSF52016; Aconitase/3IPM_dehydase_swvl; 1; .
SUPFAMSSF53732; Aconitase_N; 1; .
TIGRFAMsTIGR01341; Aconitase_1; 1; .
PROSITEPS00450; ACONITASE_1; 1; .
PROSITEPS01244; ACONITASE_2; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server