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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: AMBP_HUMAN




SWISS-2DPAGE:  AMBP_HUMAN


AMBP_HUMAN


General information about the entry
View entry in simple text format
Entry nameAMBP_HUMAN
Primary accession numberP02760
Secondary accession number(s) P00977 P02759
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMay 15, 2003 (version 1)
General Annotations were last modified on May 19, 2011 (version 16)
Name and origin of the protein
DescriptionRecName: Full=Protein AMBP; Contains: RecName: Full=Alpha-1-microglobulin; Short=Protein HC; AltName: Full=Alpha-1 microglycoprotein; AltName: Full=Complex-forming glycoprotein heterogeneous in charge; Contains: RecName: Full=Inter-alpha-trypsin inhibitor light chain; Short=ITI-LC; AltName: Full=Bikunin; AltName: Full=EDC1; AltName: Full=HI-30; AltName: Full=Uronic-acid-rich protein; Contains: RecName: Full=Trypstatin; Flags: Precursor;.
Gene nameName=AMBP
Synonyms=HCP, ITIL
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
[2]   MAPPING ON GEL
MEDLINE=78094420; PubMed=271964; [NCBI, ExPASy, EBI, Israel, Japan]
Anderson N.L., Anderson N.G.
''''''High resolution two-dimensional electrophoresis of human plasma proteins'';'';''
Proc. Natl. Acad. Sci. U.S.A. 74(1):5421-5425(1977)
Comments
  • SUBUNIT: SINGLE CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

CSF_HUMAN {Cerebrospinal Fluid}
Homo sapiens (Human)
Tissue: Cerebrospinal fluid
CSF_HUMAN
  map experimental info
  protein estimated location
 
CSF_HUMAN

MAP LOCATIONS:
pI=4.92; Mw=30928
pI=5.07; Mw=29801

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [1].



PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=4.86; Mw=33430
pI=4.96; Mw=32046
pI=5.07; Mw=30920

NORMAL LEVEL:
34-90 MG/L.

PATHOLOGICAL LEVEL:
INCREASED DURING RENAL INSUFFICIENCY AND TUBULAR PROTEINURIA.

MAPPING (identification):
MATCHING WITH THE ANDERSON'S PLASMA MAP [2].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
Siena-2DPAGEP02760; AMBP_HUMAN.
UniProtKB/Swiss-ProtP02760; AMBP_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameAMBP_HUMAN
Primary accession numberP02760
Secondary accession number(s) P00977 P02759 P78491 Q2TU33 Q5TBD7 Q9UC58 Q9UDI8
Sequence was last modified on August 13, 1987 (version 1)
Annotations were last modified on September 21, 2011 (version 148)
Name and origin of the protein
DescriptionRecName: Full=Protein AMBP; Contains: RecName: Full=Alpha-1-microglobulin; Short=Protein HC; AltName: Full=Alpha-1 microglycoprotein; AltName: Full=Complex-forming glycoprotein heterogeneous in charge; Contains: RecName: Full=Inter-alpha-trypsin inhibitor light chain; Short=ITI-LC; AltName: Full=Bikunin; AltName: Full=EDC1; AltName: Full=HI-30; AltName: Full=Uronic-acid-rich protein; Contains: RecName: Full=Trypstatin; Flags: Precursor;
Gene nameName=AMBP
Synonyms=HCP, ITIL
Encoded onName=AMBP; Synonyms=HCP, ITIL
Keywords3D-structure; Chromophore; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Host-virus interaction; Protease inhibitor; Reference proteome; Repeat; Secreted; Serine protease inhibitor; Signal.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX04225; CAA27803.1; -; mRNA
EMBLX04494; CAA28182.1; -; mRNA
EMBLX54816; CAA38585.1; -; Genomic_DNA
EMBLX54817; CAA38585.1; JOINED; Genomic_DNA
EMBLX54818; CAA38585.1; JOINED; Genomic_DNA
EMBLX54817; CAA38586.1; -; Genomic_DNA
EMBLX54818; CAA38587.1; -; Genomic_DNA
EMBLM88249; AAA59196.1; -; Genomic_DNA
EMBLM88165; AAA59196.1; JOINED; Genomic_DNA
EMBLM88243; AAA59196.1; JOINED; Genomic_DNA
EMBLM88244; AAA59196.1; JOINED; Genomic_DNA
EMBLM88246; AAA59196.1; JOINED; Genomic_DNA
EMBLM88247; AAA59196.1; JOINED; Genomic_DNA
EMBLAY544123; AAT11154.1; -; mRNA
EMBLAK290837; BAF83526.1; -; mRNA
EMBLAL137850; CAI15899.1; -; Genomic_DNA
EMBLCH471090; EAW87404.1; -; Genomic_DNA
EMBLBC041593; AAH41593.1; -; mRNA
IPIIPI00022426; -; .
PIRS13433; HCHU; .
RefSeqNP_001624.1; NM_001633.3; .
UniGeneHs.436911; -; .
PDB1BIK; X-ray; 2.50 A; A=206-352
PDBsum1BIK; -; .
ProteinModelPortalP02760; -; .
SMRP02760; 40-190; 230-339; .
IntActP02760; 3; .
MINTMINT-1367019; -; .
STRINGP02760; -; .
MEROPSI02.005; -; .
MEROPSI02.006; -; .
GlycoSuiteDBP02760; -; .
PhosphoSiteP02760; -; .
SWISS-2DPAGEP02760; -; .
Siena-2DPAGEP02760; -; .
PeptideAtlasP02760; -; .
PRIDEP02760; -; .
EnsemblENST00000265132; ENSP00000265132; ENSG00000106927; .
GeneID259; -; .
KEGGhsa:259; -; .
UCSCuc004bie.2; human; .
CTD259; -; .
GeneCardsGC09M086428; -; .
H-InvDBHIX0025747; -; .
HGNCHGNC:453; AMBP; .
HPAHPA001497; -; .
MIM176870; gene; .
neXtProtNX_P02760; -; .
PharmGKBPA24759; -; .
eggNOGprNOG10760; -; .
HOVERGENHBG000225; -; .
InParanoidP02760; -; .
OMAGKFLYHK; -; .
OrthoDBEOG4XSKQ8; -; .
PhylomeDBP02760; -; .
DrugBankDB00062; Human Serum Albumin; .
DrugBankDB00064; Serum albumin iodonated; .
NextBio1023; -; .
PMAP-CutDBP02760; -; .
ArrayExpressP02760; -; .
BgeeP02760; -; .
CleanExHS_AMBP; -; .
GenevestigatorP02760; -; .
GermOnlineENSG00000106927; Homo sapiens; .
GOGO:0005576; C:extracellular region; NAS:UniProtKB; .
GOGO:0005886; C:plasma membrane; IDA:UniProtKB; .
GOGO:0019855; F:calcium channel inhibitor activity; NAS:UniProtKB; .
GOGO:0046904; F:calcium oxalate binding; NAS:UniProtKB; .
GOGO:0020037; F:heme binding; IDA:UniProtKB; .
GOGO:0019862; F:IgA binding; IDA:UniProtKB; .
GOGO:0042803; F:protein homodimerization activity; IPI:UniProtKB; .
GOGO:0004867; F:serine-type endopeptidase inhibitor activity; TAS:UniProtKB; .
GOGO:0005215; F:transporter activity; IEA:InterPro; .
GOGO:0007155; P:cell adhesion; NAS:UniProtKB; .
GOGO:0007565; P:female pregnancy; NAS:UniProtKB; .
GOGO:0042167; P:heme catabolic process; NAS:UniProtKB; .
GOGO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW; .
GOGO:0050777; P:negative regulation of immune response; NAS:UniProtKB; .
GOGO:0046329; P:negative regulation of JNK cascade; TAS:UniProtKB; .
GOGO:0018298; P:protein-chromophore linkage; IEA:UniProtKB-KW; .
InterProIPR002968; A1-microglobln; .
InterProIPR012674; Calycin; .
InterProIPR011038; Calycin-like; .
InterProIPR002345; Lipocalin; .
InterProIPR022272; Lipocalin_CS; .
InterProIPR000566; Lipocln_cytosolic_FA-bd_dom; .
InterProIPR002223; Prot_inh_Kunz-m; .
InterProIPR020901; Prtase_inh_Kunz-CS; .
Gene3DG3DSA:2.40.128.20; Calycin; 1; .
Gene3DG3DSA:4.10.410.10; Prot_inh_Kunz-m; 2; .
PfamPF00014; Kunitz_BPTI; 2; .
PfamPF00061; Lipocalin; 1; .
PRINTSPR01215; A1MCGLOBULIN; .
PRINTSPR00759; BASICPTASE; .
PRINTSPR00179; LIPOCALIN; .
SMARTSM00131; KU; 2; .
SUPFAMSSF50814; Calycin; 1; .
SUPFAMSSF57362; Prot_inh_Kunz-m; 2; .
PROSITEPS00280; BPTI_KUNITZ_1; 2; .
PROSITEPS50279; BPTI_KUNITZ_2; 2; .
PROSITEPS00213; LIPOCALIN; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server