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Sample Preparation and Post-separation Analysis Searching in 'SWISS-2DPAGE' for entry matching: APOA4_HUMAN SWISS-2DPAGE:  APOA4_HUMAN APOA4_HUMAN General information about the entry View entry in simple text format Entry name APOA4_HUMAN Primary accession number P06727 integrated into SWISS-2DPAGE on  August 1, 1993 (release 0) 2D Annotations were last modified on December 1, 2000 (version 1) General Annotations were last modified on  May 19, 2011 (version 11) Name and origin of the protein Description RecName: Full=Apolipoprotein A-IV; Short=Apo-AIV; Short=ApoA-IV; AltName: Full=Apolipoprotein A4; Flags: Precursor;. Gene name Name=APOA4 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   MAPPING ON GEL MEDLINE=93092937; PubMed=1459097; [NCBI, Expasy, EBI, Israel, Japan] Hughes G.J., Frutiger S., Paquet N., Ravier F., Pasquali C., Sanchez J.-C., James R.W., Tissot J.-D., Bjellqvist B., Hochstrasser D.F. ''''''Plasma protein map: an update by microsequencing'';'';'' Electrophoresis 13(1):707-714(1992) [2]   MAPPING ON GEL MEDLINE=96007934; PubMed=7498157; [NCBI, Expasy, EBI, Israel, Japan] Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F. ''''''Inside SWISS-2DPAGE database'';'';'' Electrophoresis 16(1):1131-1151(1995) Comments SUBUNIT: SINGLE CHAIN 2D PAGE maps for identified proteins How to interpret a protein CSF_HUMAN {Cerebrospinal Fluid} Homo sapiens (Human) Tissue: Cerebrospinal fluid   map experimental info   protein estimated location   CSF_HUMAN MAP LOCATIONS: SPOT 2D-000C1N: pI=5.05; Mw=45212 SPOT 2D-000C1O: pI=5.09; Mw=45212 SPOT 2D-000C1P: pI=5.15; Mw=45075 MAPPING (identification): MATCHING WITH THE PLASMA MASTER GEL [2]. PLASMA_HUMAN {Plasma} Homo sapiens (Human) Tissue: Plasma   map experimental info   protein estimated location   PLASMA_HUMAN MAP LOCATIONS: SPOT 2D-00050I: pI=5.10; Mw=43391 SPOT 2D-00050J: pI=5.16; Mw=43627 SPOT 2D-00050M: pI=5.05; Mw=43391 SPOT 2D-0005FB: pI=5.11; Mw=21945 SPOT 2D-0005HX: pI=4.93; Mw=11115 SPOT 2D-0005ID: pI=4.97; Mw=10530 SPOT 2D-0005IK: pI=4.87; Mw=9922 SPOT 2D-0005J1: pI=4.96; Mw=9149 NORMAL LEVEL: 140 MG/L. PATHOLOGICAL LEVEL: DECREASED DURING TANGIER DISEASE AND ARTERIOSCLEROSIS; INCREASED DURING LIVER DISEASE. POSITIONAL VARIANTS: APO-AIV-0, 1, 2 AND 3. MAPPING (identification): MICROSEQUENCING [1]. Copyright This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). Cross-references DOSAC-COBS 2D-PAGE P06727; P06727. DOSAC-COBS-2DPAGE P06727; APOA4_HUMAN. REPRODUCTION-2DPAGE IPI00304273; IPI00304273. Siena-2DPAGE P06727; APOA4_HUMAN. UniProtKB/Swiss-Prot P06727; APOA4_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_10 Entry name APOA4_HUMAN Primary accession number P06727 Secondary accession number(s) A8MSL6 Q14CW8 Q6Q787 Sequence was last modified on  March 7, 2006 (version 3) Annotations were last modified on  October 19, 2011 (version 138) Name and origin of the protein Description RecName: Full=Apolipoprotein A-IV; Short=Apo-AIV; Short=ApoA-IV; AltName: Full=Apolipoprotein A4; Flags: Precursor; Gene name Name=APOA4 Encoded on Name=APOA4 Keywords Chylomicron; Complete proteome; HDL; Lipid transport; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Transport. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M13654; AAA51744.1; -; mRNA EMBL M14642; AAA51745.1; -; Genomic_DNA EMBL J02758; AAA96731.1; -; Genomic_DNA EMBL X13629; CAA31955.1; -; mRNA EMBL AY422950; AAQ91809.1; -; Genomic_DNA EMBL AY555191; AAS68228.1; -; Genomic_DNA EMBL AP006216; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC074764; AAH74764.1; -; mRNA EMBL BC113594; AAI13595.1; -; mRNA EMBL BC113596; AAI13597.1; -; mRNA EMBL M14566; AAA51748.1; -; mRNA IPI IPI00304273; -; . PIR A94137; LPHUA4; . UniGene Hs.1247; -; . ProteinModelPortal P06727; -; . SMR P06727; 19-297; . IntAct P06727; 1; . STRING P06727; -; . PhosphoSite P06727; -; . SWISS-2DPAGE P06727; -; . DOSAC-COBS-2DPAGE P06727; -; . REPRODUCTION-2DPAGE IPI00304273; -; . PeptideAtlas P06727; -; . PRIDE P06727; -; . Ensembl ENST00000357780; ENSP00000350425; ENSG00000110244; . UCSC uc003bnx.1; human; . GeneCards GC11M112623; -; . HGNC HGNC:602; APOA4; . HPA HPA001352; -; . HPA HPA002549; -; . MIM 107690; gene; . neXtProt NX_P06727; -; . eggNOG prNOG18920; -; . HOGENOM HBG268609; -; . HOVERGEN HBG105707; -; . InParanoid P06727; -; . OrthoDB EOG4G1MHJ; -; . PhylomeDB P06727; -; . Reactome REACT_22258; Metabolism of lipids and lipoproteins; . Reactome REACT_75925; Amyloids; . ArrayExpress P06727; -; . Bgee P06727; -; . CleanEx HS_APOA4; -; . Genevestigator P06727; -; . GermOnline ENSG00000110244; Homo sapiens; . GO GO:0042627; C:chylomicron; IDA:BHF-UCL; . GO GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome; . GO GO:0034364; C:high-density lipoprotein particle; IDA:BHF-UCL; . GO GO:0034361; C:very-low-density lipoprotein particle; IDA:BHF-UCL; . GO GO:0016209; F:antioxidant activity; IDA:HGNC; . GO GO:0017127; F:cholesterol transporter activity; IDA:BHF-UCL; . GO GO:0005507; F:copper ion binding; IDA:HGNC; . GO GO:0031210; F:phosphatidylcholine binding; IDA:BHF-UCL; . GO GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IDA:BHF-UCL; . GO GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL; . GO GO:0033344; P:cholesterol efflux; IDA:BHF-UCL; . GO GO:0042632; P:cholesterol homeostasis; IDA:BHF-UCL; . GO GO:0008203; P:cholesterol metabolic process; IDA:BHF-UCL; . GO GO:0034378; P:chylomicron assembly; TAS:BHF-UCL; . GO GO:0034371; P:chylomicron remodeling; IC:BHF-UCL; . GO GO:0034375; P:high-density lipoprotein particle remodeling; IC:BHF-UCL; . GO GO:0042744; P:hydrogen peroxide catabolic process; IDA:HGNC; . GO GO:0002227; P:innate immune response in mucosa; IDA:BHF-UCL; . GO GO:0007159; P:leukocyte cell-cell adhesion; IDA:BHF-UCL; . GO GO:0042157; P:lipoprotein metabolic process; TAS:Reactome; . GO GO:0044240; P:multicellular organismal lipid catabolic process; IDA:BHF-UCL; . GO GO:0034445; P:negative regulation of plasma lipoprotein particle oxidation; IDA:BHF-UCL; . GO GO:0046470; P:phosphatidylcholine metabolic process; IDA:BHF-UCL; . GO GO:0033700; P:phospholipid efflux; IDA:BHF-UCL; . GO GO:0010873; P:positive regulation of cholesterol esterification; IDA:BHF-UCL; . GO GO:0045723; P:positive regulation of fatty acid biosynthetic process; IDA:BHF-UCL; . GO GO:0051006; P:positive regulation of lipoprotein lipase activity; IDA:BHF-UCL; . GO GO:0010898; P:positive regulation of triglyceride catabolic process; IDA:BHF-UCL; . GO GO:0019430; P:removal of superoxide radicals; IDA:HGNC; . GO GO:0006982; P:response to lipid hydroperoxide; IDA:HGNC; . GO GO:0043691; P:reverse cholesterol transport; IDA:BHF-UCL; . GO GO:0034372; P:very-low-density lipoprotein particle remodeling; IDA:BHF-UCL; . InterPro IPR013326; ApoA/E_ApoLp; . InterPro IPR000074; ApoA1_A4_E; . Gene3D G3DSA:1.20.120.20; ApoA/E_ApoLp; 3; . Pfam PF01442; Apolipoprotein; 2; . SWISS-2DPAGE (search AC)