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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: CFAB_HUMAN




SWISS-2DPAGE:  CFAB_HUMAN


CFAB_HUMAN


General information about the entry
View entry in simple text format
Entry nameCFAB_HUMAN
Primary accession numberP00751
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onDecember 1, 2000 (version 1)
General Annotations were last modified on May 19, 2011 (version 13)
Name and origin of the protein
DescriptionRecName: Full=Complement factor B; EC=3.4.21.47; AltName: Full=C3/C5 convertase; AltName: Full=Glycine-rich beta glycoprotein; Short=GBG; AltName: Full=PBF2; AltName: Full=Properdin factor B; Contains: RecName: Full=Complement factor B Ba fragment; Contains: RecName: Full=Complement factor B Bb fragment; Flags: Precursor;.
Gene nameName=CFB
Synonyms=BF, BFD
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=78094420; PubMed=271964; [NCBI, Expasy, EBI, Israel, Japan]
Anderson N.L., Anderson N.G.
''''''High resolution two-dimensional electrophoresis of human plasma proteins'';'';''
Proc. Natl. Acad. Sci. U.S.A. 74(1):5421-5425(1977)
Comments
  • SUBUNIT: SINGLE CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=5.88; Mw=104346
pI=5.97; Mw=102877
pI=6.05; Mw=101428
pI=6.13; Mw=100000
pI=6.20; Mw=99240
pI=6.28; Mw=99240

NORMAL LEVEL:
100-400 MG/L [1].

PATHOLOGICAL LEVEL:
DECREASED DURING LUPUS ERYTHEMATOSUS, INFECTIONS WITH GRAM- BACTERIA, IMMUNOCOMPLEX NEPHRITIS, DISSAMINATED INTRAVASCULAR COAGULATION, RHEUMATOID ARTHRITIS AND MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS [1]; INCREASED DURING ACUTE INFLAMMATIONS [1].

POSITIONAL VARIANTS:
GBFF, GBFS AND GBSS VARIANTS [1].

MAPPING (identification):
IMMUNOBLOTTING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
DOSAC-COBS 2D-PAGEP00751; P00751.
DOSAC-COBS-2DPAGEP00751; CFAB_HUMAN.
REPRODUCTION-2DPAGEP00751; P00751.
Siena-2DPAGEP00751; CFAB_HUMAN.
UniProtKB/Swiss-ProtP00751; CFAB_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameCFAB_HUMAN
Primary accession numberP00751
Secondary accession number(s) B0QZQ6 O15006 Q29944 Q5JP67 Q5ST50 Q96HX6 Q9BTF5 Q9BX92
Sequence was last modified on October 1, 1994 (version 2)
Annotations were last modified on October 19, 2011 (version 164)
Name and origin of the protein
DescriptionRecName: Full=Complement factor B; EC=3.4.21.47; AltName: Full=C3/C5 convertase; AltName: Full=Glycine-rich beta glycoprotein; Short=GBG; AltName: Full=PBF2; AltName: Full=Properdin factor B; Contains: RecName: Full=Complement factor B Ba fragment; Contains: RecName: Full=Complement factor B Bb fragment; Flags: Precursor;
Gene nameName=CFB
Synonyms=BF, BFD
Encoded onName=CFB; Synonyms=BF, BFD
Keywords3D-structure; Alternative splicing; Cleavage on pair of basic residues; Complement alternate pathway; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycation; Glycoprotein; Hemolytic uremic syndrome; Hydrolase; Immunity; Innate immunity; Polymorphism; Protease; Reference proteome; Repeat; Secreted; Serine protease; Signal; Sushi; Zymogen.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX72875; CAA51389.1; -; mRNA
EMBLS67310; AAD13989.1; -; mRNA
EMBLL15702; AAA16820.1; -; mRNA
EMBLX00284; CAA25077.1; -; mRNA
EMBLAF349679; AAK30167.1; -; mRNA
EMBLAF019413; AAB67977.1; -; Genomic_DNA
EMBLAF551848; AAN71991.1; -; Genomic_DNA
EMBLAL844853; CAI41860.1; -; Genomic_DNA
EMBLAL662849; CAI17456.1; -; Genomic_DNA
EMBLBX005143; CAM25864.1; -; Genomic_DNA
EMBLCR759782; CAQ07113.1; -; Genomic_DNA
EMBLCR388219; CAQ07483.1; -; Genomic_DNA
EMBLAL645922; CAQ09274.1; -; Genomic_DNA
EMBLBC004143; AAH04143.1; -; mRNA
EMBLBC007990; AAH07990.1; -; mRNA
EMBLK01566; AAA36225.2; -; mRNA
EMBLJ00125; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLJ00126; AAA36226.1; -; mRNA
EMBLJ00185; AAA36219.1; ALT_SEQ; mRNA
EMBLJ00186; AAA36220.1; -; mRNA
EMBLM15082; AAA59625.1; -; Genomic_DNA
IPIIPI00218508; -; .
IPIIPI00921523; -; .
PIRS34075; BBHU; .
RefSeqNP_001701.2; NM_001710.5; .
UniGeneHs.69771; -; .
PDB1DLE; X-ray; 2.10 A; A/B=470-764
PDB1Q0P; X-ray; 1.80 A; A=254-476
PDB1RRK; X-ray; 2.00 A; A=268-764
PDB1RS0; X-ray; 2.60 A; A=268-764
PDB1RTK; X-ray; 2.30 A; A=268-764
PDB2OK5; X-ray; 2.30 A; A=26-764
PDB2WIN; X-ray; 3.90 A; I/J/K/L=260-764
PDB2XWB; X-ray; 3.49 A; F/H=35-764
PDB2XWJ; X-ray; 4.00 A; I/J/K/L=26-764
PDB3HRZ; X-ray; 2.20 A; D=26-764
PDB3HS0; X-ray; 3.00 A; D/I=26-764
PDBsum1DLE; -; .
PDBsum1Q0P; -; .
PDBsum1RRK; -; .
PDBsum1RS0; -; .
PDBsum1RTK; -; .
PDBsum2OK5; -; .
PDBsum2WIN; -; .
PDBsum2XWB; -; .
PDBsum2XWJ; -; .
PDBsum3HRZ; -; .
PDBsum3HS0; -; .
ProteinModelPortalP00751; -; .
SMRP00751; 35-764; .
DIPDIP-38319N; -; .
IntActP00751; 1; .
STRINGP00751; -; .
MEROPSS01.196; -; .
SWISS-2DPAGEP00751; -; .
DOSAC-COBS-2DPAGEP00751; -; .
REPRODUCTION-2DPAGEP00751; -; .
Siena-2DPAGEP00751; -; .
PeptideAtlasP00751; -; .
PRIDEP00751; -; .
EnsemblENST00000417261; ENSP00000414889; ENSG00000239754; .
EnsemblENST00000419411; ENSP00000391902; ENSG00000242335; .
EnsemblENST00000424727; ENSP00000401719; ENSG00000243570; .
EnsemblENST00000425368; ENSP00000416561; ENSG00000243649; .
EnsemblENST00000426239; ENSP00000413351; ENSG00000242335; .
EnsemblENST00000427888; ENSP00000411515; ENSG00000239754; .
EnsemblENST00000433503; ENSP00000388352; ENSG00000241534; .
EnsemblENST00000436692; ENSP00000389604; ENSG00000243570; .
EnsemblENST00000455591; ENSP00000414341; ENSG00000241534; .
GeneID629; -; .
KEGGhsa:629; -; .
UCSCuc003nyi.2; human; .
UCSCuc003nyj.2; human; .
CTD629; -; .
GeneCardsGC06P031704; -; .
H-InvDBHIX0038706; -; .
HGNCHGNC:1037; CFB; .
HPACAB016381; -; .
HPAHPA001817; -; .
HPAHPA001832; -; .
MIM138470; gene; .
MIM603075; phenotype; .
MIM612924; phenotype; .
neXtProtNX_P00751; -; .
Orphanet279; Age-related macular degeneration; .
Orphanet93578; Atypical hemolytic uremic syndrome with B factor anomaly; .
PharmGKBPA25341; -; .
eggNOGprNOG10745; -; .
HOVERGENHBG002567; -; .
InParanoidP00751; -; .
OrthoDBEOG4DV5KF; -; .
PhylomeDBP00751; -; .
BRENDA3.4.21.47; 2681; .
ReactomeREACT_6900; Immune System; .
NextBio2546; -; .
BgeeP00751; -; .
CleanExHS_CFB; -; .
GenevestigatorP00751; -; .
GermOnlineENSG00000204359; Homo sapiens; .
GOGO:0005576; C:extracellular region; TAS:Reactome; .
GOGO:0005886; C:plasma membrane; TAS:Reactome; .
GOGO:0001848; F:complement binding; TAS:UniProtKB; .
GOGO:0004252; F:serine-type endopeptidase activity; TAS:Reactome; .
GOGO:0006957; P:complement activation; alternative pathway; NAS:UniProtKB
GOGO:0006508; P:proteolysis; IEA:InterPro; .
InterProIPR011360; Compl_C2_B; .
InterProIPR016060; Complement_control_module; .
InterProIPR009003; Pept_cys/ser_Trypsin-like; .
InterProIPR018114; Peptidase_S1/S6_AS; .
InterProIPR001254; Peptidase_S1_S6; .
InterProIPR001314; Peptidase_S1A; .
InterProIPR000436; Sushi_SCR_CCP; .
InterProIPR002035; VWF_A; .
Gene3DG3DSA:2.10.70.10; Complement_control_module; 2; .
PfamPF00084; Sushi; 3; .
PfamPF00089; Trypsin; 1; .
PfamPF00092; VWA; 1; .
PIRSFPIRSF001154; Compl_C2_B; 1; .
PRINTSPR00722; CHYMOTRYPSIN; .
SMARTSM00032; CCP; 3; .
SMARTSM00020; Tryp_SPc; 1; .
SMARTSM00327; VWA; 1; .
SUPFAMSSF57535; Complement_control_module; 3; .
SUPFAMSSF50494; Pept_Ser_Cys; 1; .
PROSITEPS50923; SUSHI; 3; .
PROSITEPS50240; TRYPSIN_DOM; 1; .
PROSITEPS00134; TRYPSIN_HIS; 1; .
PROSITEPS00135; TRYPSIN_SER; 1; .
PROSITEPS50234; VWFA; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server