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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: CLIC1_HUMAN



General information about the entry
View entry in simple text format
Entry nameCLIC1_HUMAN
Primary accession numberO00299
integrated into SWISS-2DPAGE on March 31, 2004 (release 17)
2D Annotations were last modified onMarch 31, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 6)
Name and origin of the protein
DescriptionRecName: Full=Chloride intracellular channel protein 1; AltName: Full=Chloride channel ABP; AltName: Full=Nuclear chloride ion channel 27; Short=NCC27; AltName: Full=Regulatory nuclear chloride ion channel protein; Short=hRNCC;.
Gene nameName=CLIC1
Synonyms=G6, NCC27
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D.
''''''New insights into HIV lymphocyte infection'';'';''
(IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004)
2D PAGE maps for identified proteins
How to interpret a protein

Homo sapiens (Human)
Tissue: Lymphocyte
  map experimental info
  protein estimated location

pI=5.10; Mw=28586  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
UniProtKB/Swiss-ProtO00299; CLIC1_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameCLIC1_HUMAN
Primary accession numberO00299
Secondary accession number(s) Q15089 Q502X1
Sequence was last modified on January 23, 2007 (version 4)
Annotations were last modified on October 19, 2011 (version 125)
Name and origin of the protein
DescriptionRecName: Full=Chloride intracellular channel protein 1; AltName: Full=Chloride channel ABP; AltName: Full=Nuclear chloride ion channel 27; Short=NCC27; AltName: Full=Regulatory nuclear chloride ion channel protein; Short=hRNCC;
Gene nameName=CLIC1
Synonyms=G6, NCC27
Encoded onName=CLIC1; Synonyms=G6, NCC27
Keywords3D-structure; Acetylation; Cell membrane; Chloride; Chloride channel; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Glutathionylation; Ion transport; Ionic channel; Membrane; Nucleus; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLU93205; AAC25675.1; -; mRNA
EMBLAF034607; AAD20437.1; -; mRNA
EMBLAF109197; AAD26137.1; -; mRNA
EMBLAJ012008; CAB46078.1; -; Genomic_DNA
EMBLCR542071; CAG46868.1; -; mRNA
EMBLAF129756; AAD18073.1; -; Genomic_DNA
EMBLBA000025; BAB63376.1; -; Genomic_DNA
EMBLAL662899; CAI18417.1; -; Genomic_DNA
EMBLBC064527; AAH64527.1; -; mRNA
EMBLBC095469; AAH95469.1; -; mRNA
EMBLX87689; CAA61020.1; -; mRNA
IPIIPI00010896; -; .
RefSeqNP_001279.2; NM_001288.4; .
UniGeneHs.414565; -; .
PDB1K0M; X-ray; 1.40 A; A/B=1-241
PDB1K0N; X-ray; 1.80 A; A/B=1-241
PDB1K0O; X-ray; 1.75 A; A/B=1-241
PDB1RK4; X-ray; 1.79 A; A/B=1-241
PDB3O3T; X-ray; 1.70 A; A=1-241
PDB3P8W; X-ray; 2.00 A; A=1-241
PDB3P90; X-ray; 2.30 A; A=1-241
PDB3QR6; X-ray; 1.78 A; A=1-241
PDB3SWL; X-ray; 2.35 A; A=6-241
PDBsum1K0M; -; .
PDBsum1K0N; -; .
PDBsum1K0O; -; .
PDBsum1RK4; -; .
PDBsum3O3T; -; .
PDBsum3P8W; -; .
PDBsum3P90; -; .
PDBsum3QR6; -; .
PDBsum3SWL; -; .
ProteinModelPortalO00299; -; .
SMRO00299; 6-241; .
IntActO00299; 11; .
MINTMINT-1033423; -; .
STRINGO00299; -; .
TCDB1.A.12.1.2; intracellular chloride channel (CLIC) family; .
PhosphoSiteO00299; -; .
SWISS-2DPAGEO00299; -; .
Cornea-2DPAGEO00299; -; .
OGPO00299; -; .
PRIDEO00299; -; .
EnsemblENST00000375779; ENSP00000364934; ENSG00000213719; .
EnsemblENST00000375780; ENSP00000364935; ENSG00000213719; .
EnsemblENST00000375784; ENSP00000364940; ENSG00000213719; .
EnsemblENST00000383404; ENSP00000372896; ENSG00000206394; .
EnsemblENST00000383405; ENSP00000372897; ENSG00000206394; .
EnsemblENST00000395892; ENSP00000379229; ENSG00000213719; .
EnsemblENST00000400052; ENSP00000382926; ENSG00000206394; .
EnsemblENST00000400058; ENSP00000382931; ENSG00000206394; .
EnsemblENST00000415179; ENSP00000409247; ENSG00000226248; .
EnsemblENST00000418285; ENSP00000407791; ENSG00000226417; .
EnsemblENST00000420458; ENSP00000410965; ENSG00000226651; .
EnsemblENST00000422167; ENSP00000407429; ENSG00000226248; .
EnsemblENST00000423055; ENSP00000406968; ENSG00000226417; .
EnsemblENST00000423143; ENSP00000404589; ENSG00000223639; .
EnsemblENST00000423804; ENSP00000409979; ENSG00000230685; .
EnsemblENST00000425464; ENSP00000401292; ENSG00000223639; .
EnsemblENST00000431921; ENSP00000408357; ENSG00000226248; .
EnsemblENST00000433916; ENSP00000391395; ENSG00000226651; .
EnsemblENST00000434202; ENSP00000400532; ENSG00000226651; .
EnsemblENST00000435242; ENSP00000412217; ENSG00000226417; .
EnsemblENST00000438708; ENSP00000406088; ENSG00000226248; .
EnsemblENST00000438750; ENSP00000404037; ENSG00000223639; .
EnsemblENST00000442045; ENSP00000400280; ENSG00000226417; .
EnsemblENST00000447338; ENSP00000413330; ENSG00000230685; .
EnsemblENST00000447369; ENSP00000408094; ENSG00000230685; .
EnsemblENST00000451546; ENSP00000416211; ENSG00000223639; .
EnsemblENST00000456863; ENSP00000406335; ENSG00000226651; .
EnsemblENST00000457485; ENSP00000398056; ENSG00000230685; .
GeneID1192; -; .
KEGGhsa:1192; -; .
UCSCuc003nwr.1; human; .
CTD1192; -; .
GeneCardsGC06M031484; -; .
HPACAB020825; -; .
HPACAB040557; -; .
HPAHPA008917; -; .
MIM602872; gene; .
neXtProtNX_O00299; -; .
PharmGKBPA26588; -; .
eggNOGprNOG15524; -; .
HOGENOMHBG444630; -; .
HOVERGENHBG050994; -; .
InParanoidO00299; -; .
OrthoDBEOG4FR0SC; -; .
PhylomeDBO00299; -; .
NextBio4928; -; .
CleanExHS_CLIC1; -; .
GenevestigatorO00299; -; .
GermOnlineENSG00000204418; Homo sapiens; .
GOGO:0005903; C:brush border; TAS:UniProtKB; .
GOGO:0034707; C:chloride channel complex; IEA:UniProtKB-KW; .
GOGO:0005737; C:cytoplasm; IDA:UniProtKB; .
GOGO:0005624; C:membrane fraction; IDA:UniProtKB; .
GOGO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell; .
GOGO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell; .
GOGO:0005625; C:soluble fraction; IDA:UniProtKB; .
GOGO:0005515; F:protein binding; IPI:UniProtKB; .
GOGO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro; .
GOGO:0007165; P:signal transduction; TAS:UniProtKB; .
InterProIPR010987; Glutathione-S-Trfase_C-like; .
InterProIPR017933; Glutathione_S_Trfase/Cl_chnl_C; .
InterProIPR002946; Int_Cl_channel; .
InterProIPR012336; Thioredoxin-like_fold; .
Gene3DG3DSA:1.20.1050.10; GST_C_like; 1; .
Gene3DG3DSA:; Thioredoxin_fold; 1; .
SUPFAMSSF47616; GST_C_like; 1; .
SUPFAMSSF52833; Thiordxn-like_fd; 1; .
TIGRFAMsTIGR00862; O-ClC; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server