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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: CRK_HUMAN



General information about the entry
View entry in simple text format
Entry nameCRK_HUMAN
Primary accession numberP46108
integrated into SWISS-2DPAGE on January 15, 1999 (release 9)
2D Annotations were last modified onDecember 1, 2000 (version 1)
General Annotations were last modified on May 19, 2011 (version 8)
Name and origin of the protein
DescriptionRecName: Full=Adapter molecule crk; AltName: Full=Proto-oncogene c-Crk; AltName: Full=p38;.
Gene nameName=CRK
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
2D PAGE maps for identified proteins
How to interpret a protein

DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
  map experimental info
  protein estimated location

pI=5.73; Mw=34283
pI=5.57; Mw=34211
pI=5.65; Mw=34139

MAPPING (identification):

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
UniProtKB/Swiss-ProtP46108; CRK_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameCRK_HUMAN
Primary accession numberP46108
Secondary accession number(s) A8MWE8 B0LPE8 D3DTH6 Q96GA9 Q96HJ0
Sequence was last modified on July 24, 2007 (version 2)
Annotations were last modified on October 19, 2011 (version 124)
Name and origin of the protein
DescriptionRecName: Full=Adapter molecule crk; AltName: Full=Proto-oncogene c-Crk; AltName: Full=p38;
Gene nameName=CRK
Encoded onName=CRK
Keywords3D-structure; Acetylation; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Proto-oncogene; Reference proteome; Repeat; SH2 domain; SH3 domain.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLD10656; BAA01505.1; -; mRNA
EMBLS65701; AAB28213.1; -; Genomic_DNA
EMBLBT007277; AAP35941.1; -; mRNA
EMBLEU332838; ABY87527.1; -; Genomic_DNA
EMBLAK291060; BAF83749.1; -; mRNA
EMBLCH471108; EAW90621.1; -; Genomic_DNA
EMBLCH471108; EAW90624.1; -; Genomic_DNA
EMBLCH471108; EAW90625.1; -; Genomic_DNA
EMBLBC001718; AAH01718.1; -; mRNA
EMBLBC008506; AAH08506.1; -; mRNA
EMBLBC009837; AAH09837.1; -; mRNA
IPIIPI00004838; -; .
IPIIPI00399054; -; .
PIRA45022; A45022; .
RefSeqNP_005197.3; NM_005206.3; .
RefSeqNP_058431.2; NM_016823.2; .
UniGeneHs.638121; -; .
PDB1JU5; NMR; -; A=12-120
PDB2DVJ; NMR; -; A=1-228
PDB2EYV; NMR; -; A=6-124
PDB2EYW; NMR; -; A=124-198
PDB2EYX; NMR; -; A=232-298
PDB2EYY; NMR; -; A=1-204
PDB2EYZ; NMR; -; A=1-304
PDBsum1JU5; -; .
PDBsum2DVJ; -; .
PDBsum2EYV; -; .
PDBsum2EYW; -; .
PDBsum2EYX; -; .
PDBsum2EYY; -; .
PDBsum2EYZ; -; .
ProteinModelPortalP46108; -; .
SMRP46108; 1-304; .
DIPDIP-199N; -; .
DIPDIP-29388N; -; .
DIPDIP-29389N; -; .
IntActP46108; 147; .
MINTMINT-1208745; -; .
STRINGP46108; -; .
PhosphoSiteP46108; -; .
SWISS-2DPAGEP46108; -; .
PRIDEP46108; -; .
EnsemblENST00000300574; ENSP00000300574; ENSG00000167193; .
GeneID1398; -; .
KEGGhsa:1398; -; .
UCSCuc002fsl.1; human; .
CTD1398; -; .
GeneCardsGC17M001272; -; .
H-InvDBHIX0013396; -; .
HPACAB010485; -; .
MIM164762; gene; .
neXtProtNX_P46108; -; .
PharmGKBPA26880; -; .
GeneTreeENSGT00390000001475; -; .
HOGENOMHBG314739; -; .
HOVERGENHBG105616; -; .
InParanoidP46108; -; .
OrthoDBEOG4WWRK5; -; .
PhylomeDBP46108; -; .
Pathway_Interaction_DBangiopoietinreceptor_pathway; Angiopoietin receptor Tie2-mediated signaling; .
Pathway_Interaction_DBendothelinpathway; Endothelins; .
Pathway_Interaction_DBepha_fwdpathway; EPHA forward signaling; .
Pathway_Interaction_DBephbfwdpathway; EPHB forward signaling; .
Pathway_Interaction_DBigf1_pathway; IGF1 pathway; .
Pathway_Interaction_DBinsulin_pathway; Insulin Pathway; .
Pathway_Interaction_DBtcrjnkpathway; JNK signaling in the CD4+ TCR pathway; .
Pathway_Interaction_DBlysophospholipid_pathway; LPA receptor mediated events; .
Pathway_Interaction_DBtrkrpathway; Neurotrophic factor-mediated Trk receptor signaling; .
Pathway_Interaction_DBa4b1_paxdep_pathway; Paxillin-dependent events mediated by a4b1; .
Pathway_Interaction_DBa4b1_paxindep_pathway; Paxillin-independent events mediated by a4b1 and a4b7; .
Pathway_Interaction_DBpdgfrapathway; PDGFR-alpha signaling pathway; .
Pathway_Interaction_DBmet_pathway; Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met); .
Pathway_Interaction_DBptp1bpathway; Signaling events mediated by PTP1B; .
Pathway_Interaction_DBret_pathway; Signaling events regulated by Ret tyrosine kinase; .
Pathway_Interaction_DBlymphangiogenesis_pathway; VEGFR3 signaling in lymphatic endothelium; .
ReactomeREACT_11061; Signalling by NGF; .
ReactomeREACT_13552; Integrin cell surface interactions; .
ReactomeREACT_16888; Signaling by PDGF; .
ReactomeREACT_498; Signaling by Insulin receptor; .
ReactomeREACT_604; Hemostasis; .
ReactomeREACT_6900; Immune System; .
NextBio5721; -; .
ArrayExpressP46108; -; .
BgeeP46108; -; .
CleanExHS_CRK; -; .
GenevestigatorP46108; -; .
GermOnlineENSG00000167193; Homo sapiens; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0005768; C:endosome; TAS:Reactome; .
GOGO:0005634; C:nucleus; TAS:ProtInc; .
GOGO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell; .
GOGO:0046875; F:ephrin receptor binding; IPI:UniProtKB; .
GOGO:0042169; F:SH2 domain binding; IPI:UniProtKB; .
GOGO:0000186; P:activation of MAPKK activity; TAS:Reactome; .
GOGO:0007596; P:blood coagulation; TAS:Reactome; .
GOGO:0048013; P:ephrin receptor signaling pathway; IDA:UniProtKB; .
GOGO:0008286; P:insulin receptor signaling pathway; TAS:Reactome; .
GOGO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome; .
GOGO:0032956; P:regulation of actin cytoskeleton organization; IDA:UniProtKB; .
GOGO:0032319; P:regulation of Rho GTPase activity; IDA:UniProtKB; .
GOGO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc; .
InterProIPR000980; SH2; .
InterProIPR011511; SH3_2; .
InterProIPR001452; SH3_domain; .
Gene3DG3DSA:3.30.505.10; SH2; 1; .
PfamPF00017; SH2; 1; .
PfamPF00018; SH3_1; 1; .
PfamPF07653; SH3_2; 1; .
SMARTSM00252; SH2; 1; .
SMARTSM00326; SH3; 2; .
SUPFAMSSF50044; SH3; 2; .
PROSITEPS50001; SH2; 1; .
PROSITEPS50002; SH3; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server