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SWISS-2DPAGE
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Sample Preparation and Post-separation Analysis
Searching in 'SWISS-2DPAGE' for entry
matching:
CRP_HUMAN
SWISS-2DPAGE
:
CRP_HUMAN
CRP_HUMAN
General information about the entry
View entry in simple text format
Entry name
CRP_HUMAN
Primary accession number
P02741
integrated into SWISS-2DPAGE on
August 1, 1993 (release 0)
2D Annotations were last modified on
December 1, 2000 (version 1)
General Annotations were last modified on
May 19, 2011 (version 10)
Name and origin of the protein
Description
RecName: Full=C-reactive protein; Contains: RecName: Full=C-reactive protein(1-205); Flags: Precursor;.
Gene name
Name=CRP
Synonyms=PTX1
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
MAPPING ON GEL
Anderson N.L.
Personal communication (1993)
Comments
SUBUNIT
: HOMOPENTAMER
2D PAGE maps for identified proteins
How to interpret a protein
PLASMA_HUMAN
{Plasma}
Homo sapiens (Human)
Tissue: Plasma
map experimental info
protein estimated location
PLASMA_HUMAN
MAP LOCATIONS:
SPOT 2D-0005EI
:
pI=5.12; Mw=23760
NORMAL LEVEL:
2-5 MG/L [
1
].
PATHOLOGICAL LEVEL:
INCREASED DURING ACUTE AND CHRONIC BACTERIAL INFECTIONS, CELL NECROSIS, CHRONIC RENAL FAILURE, HODGKINS DISEASE AND ACTIVE RHEUMATOID ARTHRITIS [
1
].
MAPPING (identification):
IMMUNOBLOTTING [
1
].
Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See
http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html
or send email from
legal@sib.swiss
).
Cross-references
DOSAC-COBS 2D-PAGE
P02741; P02741.
DOSAC-COBS-2DPAGE
P02741; CRP_HUMAN.
Siena-2DPAGE
P02741; CRP_HUMAN.
UniProtKB/Swiss-Prot
P02741; CRP_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
2011_10
Entry name
CRP_HUMAN
Primary accession number
P02741
Secondary accession number(s)
A8K078 D3DVD9 D3DVE0 Q08AK3 Q8WW75
Sequence was last modified on
January 1, 1988 (version 1)
Annotations were last modified on
October 19, 2011 (version 149)
Name and origin of the protein
Description
RecName: Full=C-reactive protein; Contains: RecName: Full=C-reactive protein(1-205); Flags: Precursor;
Gene name
Name=CRP
Synonyms=PTX1
Encoded on
Name=CRP; Synonyms=PTX1
Keywords
3D-structure
;
Acute phase
;
Alternative splicing
;
Calcium
;
Complete proteome
;
Direct protein sequencing
;
Disulfide bond
;
Metal-binding
;
Pyrrolidone carboxylic acid
;
Reference proteome
;
Secreted
;
Signal
.
Copyright
Copyrighted by the UniProt Consortium, see
https://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
M11880; AAB59526.1
; -; Genomic_DNA
EMBL
M11725; AAA52075.1
; -; Genomic_DNA
EMBL
X56692; CAA40020.1
; -; mRNA
EMBL
X56214; CAA39671.1
; -; mRNA
EMBL
AF442818; AAL48218.2
; -; Genomic_DNA
EMBL
AK289443; BAF82132.1
; -; mRNA
EMBL
AF449713; AAL40835.1
; -; Genomic_DNA
EMBL
AL445528; CAH73654.1
; -; Genomic_DNA
EMBL
AL445528; CAH73656.1
; -; Genomic_DNA
EMBL
CH471121; EAW52778.1
; -; Genomic_DNA
EMBL
CH471121; EAW52779.1
; -; Genomic_DNA
EMBL
CH471121; EAW52780.1
; -; Genomic_DNA
EMBL
BC020766; AAH20766.1
; -; mRNA
EMBL
BC125135; AAI25136.1
; -; mRNA
EMBL
M35163; AAA52076.1
; -; mRNA
EMBL
K00518; AAA52074.1
; -; mRNA
IPI
IPI00022389; -
; .
IPI
IPI00218876; -
; .
PIR
A24515; CJHU
; .
RefSeq
NP_000558.2; NM_000567.2
; .
UniGene
Hs.709456; -
; .
UniGene
Hs.76452; -
; .
PDB
1B09; X-ray
; 2.50 A; A/B/C/D/E=19-224
PDB
1CRV; Model
; -; A/B/C/D/E=19-224
PDB
1GNH; X-ray
; 3.00 A; A/B/C/D/E/F/G/H/I/J=19-224
PDB
1LJ7; X-ray
; 3.15 A; A/B/C/D/E/F/G/H/I/J=19-224
PDB
3L2Y; X-ray
; 2.70 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T=19-224
PDBsum
1B09; -
; .
PDBsum
1CRV; -
; .
PDBsum
1GNH; -
; .
PDBsum
1LJ7; -
; .
PDBsum
3L2Y; -
; .
ProteinModelPortal
P02741; -
; .
SMR
P02741; 19-224
; .
IntAct
P02741; 3
; .
MINT
MINT-1206167; -
; .
STRING
P02741; -
; .
SWISS-2DPAGE
P02741; -
; .
DOSAC-COBS-2DPAGE
P02741; -
; .
PeptideAtlas
P02741; -
; .
PRIDE
P02741; -
; .
Ensembl
ENST00000255030; ENSP00000255030
; ENSG00000132693; .
GeneID
1401; -
; .
KEGG
hsa:1401; -
; .
UCSC
uc001ftw.1; human
; .
UCSC
uc001ftx.1; human
; .
CTD
1401; -
; .
GeneCards
GC01M131038; -
; .
H-InvDB
HIX0028720; -
; .
HGNC
HGNC:2367; CRP
; .
HPA
CAB005036; -
; .
HPA
HPA027367; -
; .
HPA
HPA027396; -
; .
MIM
123260; gene
; .
neXtProt
NX_P02741; -
; .
PharmGKB
PA120; -
; .
eggNOG
prNOG08533; -
; .
GeneTree
ENSGT00550000074240; -
; .
HOGENOM
HBG716040; -
; .
HOVERGEN
HBG005405; -
; .
InParanoid
P02741; -
; .
OMA
CTSWESA; -
; .
OrthoDB
EOG4R23VS; -
; .
PhylomeDB
P02741; -
; .
Pathway_Interaction_DB
il6_7pathway; IL6-mediated signaling events
; .
DrugBank
DB01076; Atorvastatin
; .
DrugBank
DB01393; Bezafibrate
; .
NextBio
5737; -
; .
ArrayExpress
P02741; -
; .
Bgee
P02741; -
; .
CleanEx
HS_CRP; -
; .
Genevestigator
P02741; -
; .
GermOnline
ENSG00000132693; Homo sapiens
; .
GO
GO:0033265; F:choline binding
; TAS:BHF-UCL; .
GO
GO:0051637; F:Gram-positive bacterial cell surface binding
; TAS:BHF-UCL; .
GO
GO:0030169; F:low-density lipoprotein particle binding
; IDA:BHF-UCL; .
GO
GO:0046872; F:metal ion binding
; IEA:UniProtKB-KW; .
GO
GO:0006953; P:acute-phase response
; TAS:BHF-UCL; .
GO
GO:0010888; P:negative regulation of lipid storage
; IDA:BHF-UCL; .
GO
GO:0010745; P:negative regulation of macrophage derived foam cell differentiation
; IDA:BHF-UCL; .
GO
GO:0008228; P:opsonization
; TAS:BHF-UCL; .
InterPro
IPR008985; ConA-like_lec_gl
; .
InterPro
IPR013320; ConA-like_subgrp
; .
InterPro
IPR001759; Pentaxin
; .
Gene3D
G3DSA:2.60.120.200; ConA_like_subgrp
; 1; .
Pfam
PF00354; Pentaxin
; 1; .
PRINTS
PR00895; PENTAXIN
; .
SMART
SM00159; PTX
; 1; .
SUPFAM
SSF49899; ConA_like_lec_gl
; 1; .
PROSITE
PS00289; PENTAXIN
; 1; .
SWISS-2DPAGE (search AC)
Database constructed and maintained by
SIB
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
Expasy web server