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Sample Preparation and Post-separation Analysis Searching in 'SWISS-2DPAGE' for entry matching: CRYAA_HUMAN SWISS-2DPAGE:  CRYAA_HUMAN CRYAA_HUMAN General information about the entry View entry in simple text format Entry name CRYAA_HUMAN Primary accession number P02489 integrated into SWISS-2DPAGE on  September 1, 1997 (release 6) 2D Annotations were last modified on December 30, 2004 (version 1) General Annotations were last modified on  May 19, 2011 (version 12) Name and origin of the protein Description RecName: Full=Alpha-crystallin A chain; AltName: Full=Heat shock protein beta-4; Short=HspB4; Contains: RecName: Full=Alpha-crystallin A chain, short form;. Gene name Name=CRYAA Synonyms=CRYA1, HSPB4 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   MAPPING ON GEL MEDLINE=97295305; PubMed=9150947; [NCBI, Expasy, EBI, Israel, Japan] Sarto C., Marocchi A., Sanchez J.-C., Giannone D., Frutiger S., Golaz O., Wilkins M.R., Doro G., Cappellano F., Hughes G.J., Hochstrasser D.F., Mocarelli P. ''''''Renal cell carcinoma and normal kidney protein expression'';'';'' Electrophoresis 18(1):599-604(1997) 2D PAGE maps for identified proteins How to interpret a protein KIDNEY_HUMAN {Kidney} Homo sapiens (Human) Tissue: Kidney   map experimental info   protein estimated location   KIDNEY_HUMAN MAP LOCATIONS: SPOT 2D-000NVY: pI=6.85; Mw=17247   [identification data] MAPPING (identification): AMINO ACID COMPOSITION ANALYSIS [1]. Copyright This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). Cross-references Lens-2DPAGE P02489. UniProtKB/Swiss-Prot P02489; CRYAA_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_10 Entry name CRYAA_HUMAN Primary accession number P02489 Sequence was last modified on  October 1, 1996 (version 2) Annotations were last modified on  October 19, 2011 (version 129) Name and origin of the protein Description RecName: Full=Alpha-crystallin A chain; AltName: Full=Heat shock protein beta-4; Short=HspB4; Contains: RecName: Full=Alpha-crystallin A chain, short form; Gene name Name=CRYAA Synonyms=CRYA1, HSPB4 Encoded on Name=CRYAA; Synonyms=CRYA1, HSPB4 Keywords Acetylation; Cataract; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Disulfide bond; Eye lens protein; Glycoprotein; Methylation; Nucleus; Oxidation; Phosphoprotein; Polymorphism; Reference proteome; Sensory transduction; Vision. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U05569; AAA97523.1; -; mRNA EMBL U66584; AAC50900.1; -; mRNA EMBL X14789; CAA32891.1; -; mRNA EMBL BC069528; AAH69528.1; -; mRNA EMBL M35628; AAA52106.1; -; Genomic_DNA EMBL M35629; AAA52105.1; -; Genomic_DNA EMBL AP001748; BAA95535.1; -; Genomic_DNA IPI IPI00021062; -; . PIR S03344; CYHUAA; . RefSeq NP_000385.1; NM_000394.2; . UniGene Hs.184085; -; . ProteinModelPortal P02489; -; . SMR P02489; 59-163; . DisProt DP00444; -; . DIP DIP-41265N; -; . MINT MINT-220977; -; . STRING P02489; -; . GlycoSuiteDB P02489; -; . PhosphoSite P02489; -; . SWISS-2DPAGE P02489; -; . PeptideAtlas P02489; -; . PRIDE P02489; -; . Ensembl ENST00000291554; ENSP00000291554; ENSG00000160202; . GeneID 1409; -; . KEGG hsa:1409; -; . UCSC uc002zdd.1; human; . CTD 1409; -; . GeneCards GC21P030007; -; . H-InvDB HIX0040917; -; . HGNC HGNC:2388; CRYAA; . MIM 123580; gene+phenotype; . MIM 604219; phenotype; . neXtProt NX_P02489; -; . Orphanet 98991; Nuclear cataract; . Orphanet 98995; Zonular cataract; . PharmGKB PA26906; -; . eggNOG prNOG20855; -; . HOGENOM HBG748242; -; . HOVERGEN HBG054766; -; . InParanoid P02489; -; . OMA GPKVQSG; -; . OrthoDB EOG4F1X4B; -; . PhylomeDB P02489; -; . NextBio 5761; -; . ArrayExpress P02489; -; . Bgee P02489; -; . CleanEx HS_CRYAA; -; . Genevestigator P02489; -; . GermOnline ENSG00000160202; Homo sapiens; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW; . GO GO:0051082; F:unfolded protein binding; IMP:UniProtKB; . GO GO:0006916; P:anti-apoptosis; IDA:HGNC; . GO GO:0032387; P:negative regulation of intracellular transport; IDA:HGNC; . GO GO:0051260; P:protein homooligomerization; IDA:UniProtKB; . GO GO:0007601; P:visual perception; IMP:UniProtKB; . InterPro IPR001436; Alpha-crystallin/HSP; . InterPro IPR012274; Alpha-crystallin_A; . InterPro IPR003090; Alpha-crystallin_N; . InterPro IPR002068; Hsp20; . InterPro IPR008978; HSP20-like_chaperone; . PANTHER PTHR11527:SF36; A-crystallin_A; 1; . Pfam PF00525; Crystallin; 1; . Pfam PF00011; HSP20; 1; . PIRSF PIRSF036514; Sm_HSP_B1; 1; . PRINTS PR00299; ACRYSTALLIN; . SUPFAM SSF49764; HSP20_chap; 1; . PROSITE PS01031; HSP20; 1; . SWISS-2DPAGE (search AC)