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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: CRYAB_HUMAN




SWISS-2DPAGE:  CRYAB_HUMAN


CRYAB_HUMAN


General information about the entry
View entry in simple text format
Entry nameCRYAB_HUMAN
Primary accession numberP02511
integrated into SWISS-2DPAGE on September 1, 1997 (release 6)
2D Annotations were last modified onDecember 30, 2004 (version 2)
General Annotations were last modified on May 19, 2011 (version 13)
Name and origin of the protein
DescriptionRecName: Full=Alpha-crystallin B chain; AltName: Full=Alpha(B)-crystallin; AltName: Full=Heat shock protein beta-5; Short=HspB5; AltName: Full=Renal carcinoma antigen NY-REN-27; AltName: Full=Rosenthal fiber component;.
Gene nameName=CRYAB
Synonyms=CRYA2
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=97295305; PubMed=9150947; [NCBI, Expasy, EBI, Israel, Japan]
Sarto C., Marocchi A., Sanchez J.-C., Giannone D., Frutiger S., Golaz O., Wilkins M.R., Doro G., Cappellano F., Hughes G.J., Hochstrasser D.F., Mocarelli P.
''''''Renal cell carcinoma and normal kidney protein expression'';'';''
Electrophoresis 18(1):599-604(1997)
[2]   MAPPING ON GEL
MEDLINE=98163346; PubMed=9504818; [NCBI, Expasy, EBI, Israel, Japan]
Reymond M.A., Sanchez J.-C., Hughes G.J., Riese J., Tortola S., Peinado M.A., Kirchner T., Hohenberger W., Hochstrasser D.F., Kockerling F.
''''''Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis'';'';''
Electrophoresis 18(1):2842-2848(1997)
2D PAGE maps for identified proteins
How to interpret a protein

CEC_HUMAN {Colorectal epithelia cells}
Homo sapiens (Human)
Tissue: Colon epithelium
CEC_HUMAN
  map experimental info
  protein estimated location
 
CEC_HUMAN

MAP LOCATIONS:
pI=8.52; Mw=16874

MAPPING (identification):
MATCHING WITH THE KIDNEY MASTER GEL [2].



KIDNEY_HUMAN {Kidney}
Homo sapiens (Human)
Tissue: Kidney
KIDNEY_HUMAN
  map experimental info
  protein estimated location
 
KIDNEY_HUMAN

MAP LOCATIONS:
pI=7.23; Mw=15636

MAPPING (identification):
MICROSEQUENCING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
HSC-2DPAGEP02511; HUMAN.
Lens-2DPAGEP02511.
REPRODUCTION-2DPAGEIPI00021369; IPI00021369.
UCD-2DPAGEP02511; CRYAB_HUMAN.
UniProtKB/Swiss-ProtP02511; CRYAB_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameCRYAB_HUMAN
Primary accession numberP02511
Secondary accession number(s) B0YIX0 O43416 Q9UC37 Q9UC38 Q9UC39 Q9UC40 Q9UC41
Sequence was last modified on January 1, 1990 (version 2)
Annotations were last modified on October 19, 2011 (version 144)
Name and origin of the protein
DescriptionRecName: Full=Alpha-crystallin B chain; AltName: Full=Alpha(B)-crystallin; AltName: Full=Heat shock protein beta-5; Short=HspB5; AltName: Full=Renal carcinoma antigen NY-REN-27; AltName: Full=Rosenthal fiber component;
Gene nameName=CRYAB
Synonyms=CRYA2
Encoded onName=CRYAB; Synonyms=CRYA2
Keywords3D-structure; Acetylation; Cataract; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Eye lens protein; Glycoprotein; Methylation; Myofibrillar myopathy; Nucleus; Oxidation; Phosphoprotein; Polymorphism; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM28638; AAA52104.1; -; Genomic_DNA
EMBLS45630; AAB23453.1; -; mRNA
EMBLAF007162; AAC19161.1; -; mRNA
EMBLAK314029; BAG36739.1; -; mRNA
EMBLBT006770; AAP35416.1; -; mRNA
EMBLEF444955; ACA05949.1; -; Genomic_DNA
EMBLCH471065; EAW67162.1; -; Genomic_DNA
EMBLBC007008; AAH07008.1; -; mRNA
EMBLM24906; AAA60267.1; -; mRNA
IPIIPI00021369; -; .
PIRA35332; CYHUAB; .
RefSeqNP_001876.1; NM_001885.1; .
UniGeneHs.53454; -; .
PDB2KLR; NMR; -; A/B=1-175
PDB2WJ7; X-ray; 2.63 A; A/B/C/D/E=67-157
PDB2Y1Y; X-ray; 2.00 A; A=71-157
PDB2Y1Z; X-ray; 2.50 A; A/B=67-157
PDB2Y22; X-ray; 3.70 A; A/B/C/D/E/F=67-157
PDB3L1G; X-ray; 3.32 A; A=68-162
PDBsum2KLR; -; .
PDBsum2WJ7; -; .
PDBsum2Y1Y; -; .
PDBsum2Y1Z; -; .
PDBsum2Y22; -; .
PDBsum3L1G; -; .
ProteinModelPortalP02511; -; .
SMRP02511; 68-162; .
DisProtDP00445; -; .
DIPDIP-35017N; -; .
IntActP02511; 5; .
MINTMINT-221013; -; .
STRINGP02511; -; .
GlycoSuiteDBP02511; -; .
PhosphoSiteP02511; -; .
SWISS-2DPAGEP02511; -; .
REPRODUCTION-2DPAGEIPI00021369; -; .
UCD-2DPAGEP02511; -; .
PRIDEP02511; -; .
EnsemblENST00000227251; ENSP00000227251; ENSG00000109846; .
GeneID1410; -; .
KEGGhsa:1410; -; .
UCSCuc001pmf.1; human; .
CTD1410; -; .
GeneCardsGC11M107703; -; .
HGNCHGNC:2389; CRYAB; .
HPACAB002053; -; .
HPACAB040560; -; .
HPAHPA028724; -; .
MIM123590; gene; .
MIM608810; phenotype; .
MIM613763; phenotype; .
MIM613869; phenotype; .
neXtProtNX_P02511; -; .
Orphanet98910; Alpha-crystallinopathy; .
Orphanet98993; Posterior polar cataract; .
Orphanet98995; Zonular cataract; .
PharmGKBPA26907; -; .
eggNOGprNOG15526; -; .
GeneTreeENSGT00550000074302; -; .
HOVERGENHBG054766; -; .
InParanoidP02511; -; .
OMAPGPERTI; -; .
OrthoDBEOG4G1MHK; -; .
PhylomeDBP02511; -; .
NextBio5765; -; .
PMAP-CutDBP02511; -; .
ArrayExpressP02511; -; .
BgeeP02511; -; .
CleanExHS_CRYAB; -; .
GenevestigatorP02511; -; .
GermOnlineENSG00000109846; Homo sapiens; .
GOGO:0005737; C:cytoplasm; IDA:UniProtKB; .
GOGO:0005634; C:nucleus; IDA:UniProtKB; .
GOGO:0042803; F:protein homodimerization activity; IPI:UniProtKB; .
GOGO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW; .
GOGO:0051082; F:unfolded protein binding; IPI:UniProtKB; .
GOGO:0006916; P:anti-apoptosis; IDA:HGNC; .
GOGO:0006936; P:muscle contraction; TAS:ProtInc; .
GOGO:0032387; P:negative regulation of intracellular transport; IDA:HGNC; .
GOGO:0006457; P:protein folding; NAS:ProtInc; .
GOGO:0051260; P:protein homooligomerization; IDA:UniProtKB; .
InterProIPR001436; Alpha-crystallin/HSP; .
InterProIPR012273; Alpha-crystallin_B; .
InterProIPR003090; Alpha-crystallin_N; .
InterProIPR002068; Hsp20; .
InterProIPR008978; HSP20-like_chaperone; .
PANTHERPTHR11527:SF37; A-crystallin_B; 1; .
PfamPF00525; Crystallin; 1; .
PfamPF00011; HSP20; 1; .
PIRSFPIRSF036514; Sm_HSP_B1; 1; .
PRINTSPR00299; ACRYSTALLIN; .
SUPFAMSSF49764; HSP20_chap; 1; .
PROSITEPS01031; HSP20; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server