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Sample Preparation and Post-separation Analysis Searching in 'SWISS-2DPAGE' for entry matching: GPX1_HUMAN SWISS-2DPAGE:  GPX1_HUMAN GPX1_HUMAN General information about the entry View entry in simple text format Entry name GPX1_HUMAN Primary accession number P07203 integrated into SWISS-2DPAGE on  August 1, 1993 (release 0) 2D Annotations were last modified on March 31, 2004 (version 1) General Annotations were last modified on  May 19, 2011 (version 13) Name and origin of the protein Description RecName: Full=Glutathione peroxidase 1; Short=GPx-1; Short=GSHPx-1; EC=1.11.1.9; AltName: Full=Cellular glutathione peroxidase;. Gene name Name=GPX1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   MAPPING ON GEL MEDLINE=93120196; PubMed=1477117; [NCBI, Expasy, EBI, Israel, Japan] Golaz O., Walzer C., Hochstrasser D.F., Bjellqvist B., Turler H., Balant L.P. ''''''Red blood cell protein map: a comparison between carrier-ampholyte pH gradient and immobilized pH gradient, and identification of four red blood cell enzymes'';'';'' Appl. Theor. Electrophor. 3(1):77-82(1992) Comments SUBUNIT: HOMOTETRAMER 2D PAGE maps for identified proteins How to interpret a protein RBC_HUMAN {Red blood cells} Homo sapiens (Human) Tissue: Erythrocyte   map experimental info   protein estimated location   RBC_HUMAN MAP LOCATIONS: SPOT 2D-0006MP: pI=5.85; Mw=19224 SPOT 2D-0006MS: pI=5.36; Mw=18964 PATHOLOGICAL LEVEL: DECREASED IN A FORM OF HEMOLYTIC ANEMIA [1]. MAPPING (identification): COMIGRATION [1]. Copyright This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). Cross-references OGP-WWW P07203. UniProtKB/Swiss-Prot P07203; GPX1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_10 Entry name GPX1_HUMAN Primary accession number P07203 Secondary accession number(s) Q7Z5H1 Q9BW12 Sequence was last modified on  November 2, 2010 (version 4) Annotations were last modified on  October 19, 2011 (version 141) Name and origin of the protein Description RecName: Full=Glutathione peroxidase 1; Short=GPx-1; Short=GSHPx-1; EC=1.11.1.9; AltName: Full=Cellular glutathione peroxidase; Gene name Name=GPX1 Encoded on Name=GPX1 Keywords 3D-structure; Acetylation; Complete proteome; Cytoplasm; Oxidoreductase; Peroxidase; Polymorphism; Reference proteome; Selenocysteine. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL Y00433; CAA68491.1; -; mRNA EMBL Y00483; CAB37833.1; -; Genomic_DNA EMBL X13709; CAA31992.1; -; mRNA EMBL X13710; CAA31993.1; -; mRNA EMBL M21304; AAA75389.2; -; mRNA EMBL M83094; AAA67540.2; -; Genomic_DNA EMBL AY327818; AAP80181.1; -; Genomic_DNA EMBL AC121247; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC000742; AAH00742.3; -; mRNA IPI IPI00927606; -; . PIR A42152; OPHUE; . RefSeq NP_000572.2; NM_000581.2; . RefSeq NP_958799.1; NM_201397.1; . UniGene Hs.76686; -; . PDB 2F8A; X-ray; 1.50 A; A/B=14-196 PDBsum 2F8A; -; . ProteinModelPortal P07203; -; . SMR P07203; 14-197; . STRING P07203; -; . PeroxiBase 3600; HsGPx01-a; . PhosphoSite P07203; -; . SWISS-2DPAGE P07203; -; . OGP P07203; -; . PRIDE P07203; -; . Ensembl ENST00000419783; ENSP00000407375; ENSG00000233276; . GeneID 2876; -; . KEGG hsa:2876; -; . CTD 2876; -; . GeneCards GC03M049369; -; . H-InvDB HIX0003298; -; . HGNC HGNC:4553; GPX1; . HPA CAB011582; -; . MIM 138320; gene+phenotype; . neXtProt NX_P07203; -; . PharmGKB PA28949; -; . eggNOG prNOG12554; -; . HOGENOM HBG648990; -; . HOVERGEN HBG004333; -; . InParanoid P07203; -; . OMA CRNDISW; -; . OrthoDB EOG4SBF08; -; . BioCyc MetaCyc:MONOMER-9882; -; . Reactome REACT_1698; Metabolism of nucleotides; . DrugBank DB00143; Glutathione; . NextBio 11353; -; . Bgee P07203; -; . CleanEx HS_GPX1; -; . Genevestigator P07203; -; . GermOnline ENSG00000211447; Homo sapiens; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0005739; C:mitochondrion; IDA:BHF-UCL; . GO GO:0004866; F:endopeptidase inhibitor activity; IDA:BHF-UCL; . GO GO:0004602; F:glutathione peroxidase activity; IDA:BHF-UCL; . GO GO:0017124; F:SH3 domain binding; IPI:BHF-UCL; . GO GO:0006916; P:anti-apoptosis; IMP:BHF-UCL; . GO GO:0045454; P:cell redox homeostasis; IDA:BHF-UCL; . GO GO:0006749; P:glutathione metabolic process; IDA:BHF-UCL; . GO GO:0060047; P:heart contraction; IMP:BHF-UCL; . GO GO:0042744; P:hydrogen peroxide catabolic process; IDA:BHF-UCL; . GO GO:0043154; P:negative regulation of caspase activity; IMP:BHF-UCL; . GO GO:0006144; P:purine base metabolic process; TAS:Reactome; . GO GO:0006195; P:purine nucleotide catabolic process; TAS:Reactome; . GO GO:0040029; P:regulation of gene expression; epigenetic; IDA:BHF-UCL GO GO:0033599; P:regulation of mammary gland epithelial cell proliferation; IMP:BHF-UCL; . GO GO:0061136; P:regulation of proteasomal protein catabolic process; IDA:BHF-UCL; . GO GO:0001836; P:release of cytochrome c from mitochondria; IMP:BHF-UCL; . GO GO:0010269; P:response to selenium ion; IMP:BHF-UCL; . GO GO:0009650; P:UV protection; IMP:BHF-UCL; . InterPro IPR000889; Glutathione_peroxidase; . InterPro IPR012336; Thioredoxin-like_fold; . Gene3D G3DSA:3.40.30.10; Thioredoxin_fold; 1; . PANTHER PTHR11592; Glut_peroxidase; 1; . Pfam PF00255; GSHPx; 1; . PIRSF PIRSF000303; Glutathion_perox; 1; . PRINTS PR01011; GLUTPROXDASE; . SUPFAM SSF52833; Thiordxn-like_fd; 1; . PROSITE PS00460; GLUTATHIONE_PEROXID_1; 1; . PROSITE PS00763; GLUTATHIONE_PEROXID_2; 1; . PROSITE PS51355; GLUTATHIONE_PEROXID_3; 1; . SWISS-2DPAGE (search AC)