| General information about the entry |
| View entry in simple text format |
| Entry name | HPT_HUMAN |
| Primary accession number | P00738 |
| Secondary accession number(s) | P00737 |
| integrated into SWISS-2DPAGE on | August 1, 1993 (release 0) |
| 2D Annotations were last modified on | March 31, 2004 (version 4) |
| General Annotations were last modified on | May 19, 2011 (version 15) |
| Name and origin of the protein |
| Description | RecName: Full=Haptoglobin; Contains: RecName: Full=Haptoglobin alpha chain; Contains: RecName: Full=Haptoglobin beta chain; Flags: Precursor;. |
| Gene name | Name=HP
|
| Annotated species | Homo sapiens (Human) [TaxID: 9606] |
| Taxonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
| References |
| [1] |
MAPPING ON GEL
MEDLINE=93162045; PubMed=1286669; [NCBI, Expasy, EBI, Israel, Japan]
Hochstrasser D.F., Frutiger S., Paquet N., Bairoch A., Ravier F., Pasquali C., Sanchez J.-C., Tissot J.-D., Bjellqvist B., Vargas R., Appel R.D., Hughes G.J.
''''''Human liver protein map: a reference database established by microsequencing and gel comparison'';'';''
Electrophoresis 13(1):992-1001(1992)
|
| [2] |
GENETIC VARIANTS
MEDLINE=83019292; PubMed=6751044; [NCBI, Expasy, EBI, Israel, Japan]
Bowman B.H., Kurosky A.
''''''Haptoglobin: the evolutionary product of duplication, unequal crossing over, and point mutation'';'';''
Adv. Hum. Genet. 12(1):189-261(1982)
|
| [3] |
MAPPING ON GEL
MEDLINE=78094420; PubMed=271964; [NCBI, Expasy, EBI, Israel, Japan]
Anderson N.L., Anderson N.G.
''''''High resolution two-dimensional electrophoresis of human plasma proteins'';'';''
Proc. Natl. Acad. Sci. U.S.A. 74(1):5421-5425(1977)
|
| [4] |
MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, Expasy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
|
| [5] |
MAPPING ON GEL
MEDLINE=93092937; PubMed=1459097; [NCBI, Expasy, EBI, Israel, Japan]
Hughes G.J., Frutiger S., Paquet N., Ravier F., Pasquali C., Sanchez J.-C., James R.W., Tissot J.-D., Bjellqvist B., Hochstrasser D.F.
''''''Plasma protein map: an update by microsequencing'';'';''
Electrophoresis 13(1):707-714(1992)
|
| [6] |
MAPPING ON GEL
MEDLINE=97397181; PubMed=9253242; [NCBI, Expasy, EBI, Israel, Japan]
Eckerskorn C., Strupat K., Schleuder D., Hochstrasser D.F., Sanchez J.-C., Lottspeich F., Hillenkamp F.
''''''Analysis of proteins by direct-scanning infrared-MALDI mass spectrometry after 2D-PAGE separation and electroblotting'';'';''
Anal. Chem. 69(1):2888-2892(1997)
|
|
| Comments |
- SUBUNIT: TETRAMER OF TWO ALPHA-1 AND TWO BETA CHAINS
|
| 2D PAGE maps for identified proteins
|
|
How to interpret a protein
|
CSF_HUMAN {Cerebrospinal Fluid}
Homo sapiens (Human)
Tissue: Cerebrospinal fluid
map experimental info
protein estimated location
|
|
CSF_HUMAN
MAP LOCATIONS:
MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [4].
|
HEPG2SP_HUMAN {HepG2 Secreted Proteins}
Homo sapiens (Human)
Tissue: Hepatoblastoma
map experimental info
protein estimated location
|
|
HEPG2SP_HUMAN
MAP LOCATIONS:
MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [4].
|
LIVER_HUMAN {Liver}
Homo sapiens (Human)
Tissue: Liver
map experimental info
protein estimated location
|
|
LIVER_HUMAN
MAP LOCATIONS:
NORMAL POSITIONAL VARIANTS:
HP1-1; HP2-1; HP2-2; SOME RARE VARIANTS [2].
PATHOLOGICAL LEVEL:
DECREASED DURING LIVER DISEASE AND HAEMOLYTIC ANAEMIAS; INCREASED DURING ACUTE-PHASE.
MAPPING (identification):
MATCHING WITH A PLASMA GEL [1].
|
LYMPHOMA_HUMAN {Lymphoma}
Homo sapiens (Human)
Tissue: Lymphoma
map experimental info
protein estimated location
|
|
LYMPHOMA_HUMAN
MAP LOCATIONS:
MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [4].
|
PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
map experimental info
protein estimated location
|
|
PLASMA_HUMAN
MAP LOCATIONS:
NORMAL LEVEL:
1000-3000 MG/L.
PATHOLOGICAL LEVEL:
DECREASED DURING LIVER DISEASE AND HAEMOLYTIC ANAEMIAS; INCREASED DURING ACUTE-PHASE.
POSITIONAL VARIANTS:
HP1-1; HP2-1; HP2-2; SOME RARE VARIANTS [2].
MAPPING (identification):
| SPOTS 2D-00*: IMMUNOBLOTTING [3]; SPOTS 2D-0005G*: MICROSEQUENCING [5] AND MASS spectrometry [6]. |
|
| Copyright |
| This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). |
| Cross-references |
| DOSAC-COBS 2D-PAGE | P00738; P00738. |
| DOSAC-COBS-2DPAGE | P00738; HPT_HUMAN. |
| HSC-2DPAGE | P00737; HUMAN. |
| Siena-2DPAGE | P00738; HPT_HUMAN. |
| UCD-2DPAGE | P00737; HPT_HUMAN. |
| UniProtKB/Swiss-Prot | P00738; HPT_HUMAN. |
| 2D PAGE maps for identified proteins
|
- How to interpret a protein map
- You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
- Warning 1: the displayed region reflects
an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information.
It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
- Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
|
