resource logo

SWISS-2DPAGE

Attention: World-2DPAGE is no longer maintained.


SWISS-2DPAGE 
Search by  [accession number] *
[description, ID or gene] 
[author names] 
[spot ID / serial number] 
[identification methods] 
[pI / Mw range] 
[combined fields] 

Maps  [experimental info] 
[protein list] 
[graphical interface]

     Select Remote Interfaces
[All Interfaces]
World-2DPAGE Portal
World-2DPAGE Repository

Exclude local DBs
has only effect if a remote
interface is selected
     

Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P01008




SWISS-2DPAGE:  P01008


P01008


General information about the entry
View entry in simple text format
Entry nameANT3_HUMAN
Primary accession numberP01008
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMay 15, 2003 (version 1)
General Annotations were last modified on May 19, 2011 (version 14)
Name and origin of the protein
DescriptionRecName: Full=Antithrombin-III; Short=ATIII; AltName: Full=Serpin C1; Flags: Precursor;.
Gene nameName=SERPINC1
Synonyms=AT3
ORFNames=PRO0309
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93092937; PubMed=1459097; [NCBI, Expasy, EBI, Israel, Japan]
Hughes G.J., Frutiger S., Paquet N., Ravier F., Pasquali C., Sanchez J.-C., James R.W., Tissot J.-D., Bjellqvist B., Hochstrasser D.F.
''''''Plasma protein map: an update by microsequencing'';'';''
Electrophoresis 13(1):707-714(1992)
Comments
  • SUBUNIT: SINGLE CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=5.20; Mw=58973
pI=5.27; Mw=58653

NORMAL LEVEL:
220-390 MG/L [1].

PATHOLOGICAL LEVEL:
DECREASED DURING NEPHROTIC SYNDROME, HYPERCOAGULABILITY, DEEP VEIN THROMBOSIS, ORAL CONTRACEPTIVES, PULMONARY EMBOLISM, DISSAMINATED INTRAVASCULAR COAGULATION, DIRECT HEPATOTOXICITY AND EXTRACORPORAL CIRCULATION [1].

POSITIONAL VARIANTS:
MORE THAN 20 VARIANTS [1].

MAPPING (identification):
MICROSEQUENCING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
DOSAC-COBS 2D-PAGEP01008; P01008.
DOSAC-COBS-2DPAGEP01008; ANT3_HUMAN.
REPRODUCTION-2DPAGEP01008; P01008.
Siena-2DPAGEP01008; ANT3_HUMAN.
UniProtKB/Swiss-ProtP01008; ANT3_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameANT3_HUMAN
Primary accession numberP01008
Secondary accession number(s) B2R6P0 P78439 P78447 Q13815 Q5TC78 Q7KZ43 Q7KZ97 Q9UC78
Sequence was last modified on July 21, 1986 (version 1)
Annotations were last modified on October 19, 2011 (version 161)
Name and origin of the protein
DescriptionRecName: Full=Antithrombin-III; Short=ATIII; AltName: Full=Serpin C1; Flags: Precursor;
Gene nameName=SERPINC1
Synonyms=AT3
ORFNames=PRO0309
Encoded onName=SERPINC1; Synonyms=AT3; ORFNames=PRO0309
Keywords3D-structure; Blood coagulation; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Heparin-binding; Phosphoprotein; Polymorphism; Protease inhibitor; Reference proteome; Secreted; Serine protease inhibitor; Signal; Thrombophilia.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLL00185; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLL00186; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLL00190; AAB40025.1; -; Genomic_DNA
EMBLD29832; BAA06212.1; -; mRNA
EMBLX68793; CAA48690.1; -; Genomic_DNA
EMBLAF130100; AAG35525.1; -; mRNA
EMBLAK312654; BAG35537.1; -; mRNA
EMBLAF386078; AAK60337.1; -; Genomic_DNA
EMBLAL136170; CAI19423.1; -; Genomic_DNA
EMBLCH471067; EAW90969.1; -; Genomic_DNA
EMBLM21643; AAA51793.1; -; Genomic_DNA
EMBLM21644; AAA51794.1; -; Genomic_DNA
EMBLM21643; AAA51794.1; JOINED; Genomic_DNA
EMBLM21642; AAA51796.1; -; Genomic_DNA
EMBLM21636; AAA51796.1; JOINED; Genomic_DNA
EMBLM21637; AAA51796.1; JOINED; Genomic_DNA
EMBLM21638; AAA51796.1; JOINED; Genomic_DNA
EMBLM21640; AAA51796.1; JOINED; Genomic_DNA
EMBLM21641; AAA51796.1; JOINED; Genomic_DNA
IPIIPI00032179; -; .
PIRA49494; XHHU3; .
RefSeqNP_000479.1; NM_000488.3; .
UniGeneHs.75599; -; .
PDB1ANT; X-ray; 3.00 A; I/L=33-464
PDB1ATH; X-ray; 3.20 A; A/B=33-464
PDB1AZX; X-ray; 2.90 A; I/L=33-464
PDB1BR8; X-ray; 2.90 A; I/L=33-464
PDB1DZG; X-ray; 2.80 A; I/L=33-464
PDB1DZH; X-ray; 2.85 A; I/L=33-464
PDB1E03; X-ray; 2.90 A; I/L=33-464
PDB1E04; X-ray; 2.60 A; I/L=33-464
PDB1E05; X-ray; 2.62 A; I/L=33-464
PDB1JVQ; X-ray; 2.60 A; I/L=33-464
PDB1LK6; X-ray; 2.80 A; I/L=33-464
PDB1NQ9; X-ray; 2.60 A; I/L=33-464
PDB1OYH; X-ray; 2.62 A; I/L=33-464
PDB1R1L; X-ray; 2.70 A; I/L=33-464
PDB1SR5; X-ray; 3.10 A; A=33-464
PDB1T1F; X-ray; 2.75 A; A/B/C=33-464
PDB1TB6; X-ray; 2.50 A; I=33-464
PDB2ANT; X-ray; 2.60 A; I/L=33-464
PDB2B4X; X-ray; 2.80 A; I/L=37-463
PDB2B5T; X-ray; 2.10 A; I=33-464
PDB2BEH; X-ray; 2.70 A; I/L=33-464
PDB2GD4; X-ray; 3.30 A; C/I=22-464
PDB2HIJ; X-ray; 2.90 A; I/L=33-464
PDB2ZNH; X-ray; 2.80 A; A/B=33-464
PDB3EVJ; X-ray; 3.00 A; I/L=33-464
PDB3KCG; X-ray; 1.70 A; I=33-464
PDBsum1ANT; -; .
PDBsum1ATH; -; .
PDBsum1AZX; -; .
PDBsum1BR8; -; .
PDBsum1DZG; -; .
PDBsum1DZH; -; .
PDBsum1E03; -; .
PDBsum1E04; -; .
PDBsum1E05; -; .
PDBsum1JVQ; -; .
PDBsum1LK6; -; .
PDBsum1NQ9; -; .
PDBsum1OYH; -; .
PDBsum1R1L; -; .
PDBsum1SR5; -; .
PDBsum1T1F; -; .
PDBsum1TB6; -; .
PDBsum2ANT; -; .
PDBsum2B4X; -; .
PDBsum2B5T; -; .
PDBsum2BEH; -; .
PDBsum2GD4; -; .
PDBsum2HIJ; -; .
PDBsum2ZNH; -; .
PDBsum3EVJ; -; .
PDBsum3KCG; -; .
ProteinModelPortalP01008; -; .
SMRP01008; 37-463; .
DIPDIP-38009N; -; .
IntActP01008; 2; .
STRINGP01008; -; .
MEROPSI04.018; -; .
PhosphoSiteP01008; -; .
SWISS-2DPAGEP01008; -; .
Cornea-2DPAGEP01008; -; .
DOSAC-COBS-2DPAGEP01008; -; .
REPRODUCTION-2DPAGEP01008; -; .
PRIDEP01008; -; .
EnsemblENST00000367698; ENSP00000356671; ENSG00000117601; .
GeneID462; -; .
KEGGhsa:462; -; .
UCSCuc001gjt.1; human; .
CTD462; -; .
GeneCardsGC01M145098; -; .
H-InvDBHIX0199984; -; .
HGNCHGNC:775; SERPINC1; .
HPACAB016790; -; .
HPAHPA001816; -; .
HPAHPA024007; -; .
MIM107300; gene; .
MIM188050; phenotype; .
MIM613118; phenotype; .
neXtProtNX_P01008; -; .
Orphanet82; Hereditary thrombophilia due to congenital antithrombin deficiency; .
PharmGKBPA35026; -; .
eggNOGprNOG17846; -; .
HOVERGENHBG005957; -; .
InParanoidP01008; -; .
OMAKFRYRRV; -; .
OrthoDBEOG4SF968; -; .
PhylomeDBP01008; -; .
Pathway_Interaction_DBglypican_1pathway; Glypican 1 network; .
ReactomeREACT_604; Hemostasis; .
DrugBankDB01225; Enoxaparin; .
DrugBankDB00569; Fondaparinux sodium; .
DrugBankDB01109; Heparin; .
NextBio1911; -; .
PMAP-CutDBP01008; -; .
ArrayExpressP01008; -; .
BgeeP01008; -; .
CleanExHS_SERPINC1; -; .
GenevestigatorP01008; -; .
GermOnlineENSG00000117601; Homo sapiens; .
GOGO:0005615; C:extracellular space; IDA:BHF-UCL; .
GOGO:0005886; C:plasma membrane; TAS:Reactome; .
GOGO:0008201; F:heparin binding; IEA:UniProtKB-KW; .
GOGO:0002020; F:protease binding; IPI:UniProtKB; .
GOGO:0004867; F:serine-type endopeptidase inhibitor activity; NAS:UniProtKB; .
GOGO:0007596; P:blood coagulation; TAS:Reactome; .
GOGO:0030162; P:regulation of proteolysis; IBA:RefGenome; .
InterProIPR000215; Protease_inhib_I4_serpin; .
InterProIPR023795; Protease_inhib_I4_serpin_CS; .
InterProIPR015555; Protease_inhib_serpin_AT-III; .
InterProIPR023796; Sepin_dom; .
PANTHERPTHR11461; Prot_inh_serpin; 1; .
PANTHERPTHR11461:SF53; Serpin_ATIII; 1; .
PfamPF00079; Serpin; 1; .
SMARTSM00093; SERPIN; 1; .
SUPFAMSSF56574; Prot_inh_serpin; 1; .
PROSITEPS00284; SERPIN; 1; .



SWISS-2DPAGE image

SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server