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SWISS-2DPAGE

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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P02675




SWISS-2DPAGE:  P02675


P02675


General information about the entry
View entry in simple text format
Entry nameFIBB_HUMAN
Primary accession numberP02675
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMarch 31, 2004 (version 1)
General Annotations were last modified on November 9, 2011 (version 15)
Name and origin of the protein
DescriptionRecName: Full=Fibrinogen beta chain; Contains: RecName: Full=Fibrinopeptide B; Contains: RecName: Full=Fibrinogen beta chain; Flags: Precursor;.
Gene nameName=FGB
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=78094420; PubMed=271964; [NCBI, Expasy, EBI, Israel, Japan]
Anderson N.L., Anderson N.G.
''''''High resolution two-dimensional electrophoresis of human plasma proteins'';'';''
Proc. Natl. Acad. Sci. U.S.A. 74(1):5421-5425(1977)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, Expasy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
Comments
  • SUBUNIT: HEXAMER OF TWO SET OF ALPHA, BETA, AND GAMMA CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

HEPG2SP_HUMAN {HepG2 Secreted Proteins}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2SP_HUMAN
  map experimental info
  protein estimated location
 
HEPG2SP_HUMAN

MAP LOCATIONS:
pI=6.25; Mw=51560
pI=6.53; Mw=51056
pI=6.79; Mw=50723
pI=6.96; Mw=50723

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [2].



PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=6.10; Mw=56160
pI=6.27; Mw=55704
pI=6.41; Mw=55252
pI=6.55; Mw=54804

NORMAL LEVEL:
2000-4500 MG/L.

PATHOLOGICAL LEVEL:
DECREASED DURING DISSAMINATED INTRAVASCULAR COAGULATION AND HYPERFIBRINOLYSIS; INCREASED DURING ACUTE INFLAMMATION.

MAPPING (identification):
IMMUNOBLOTTING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
DOSAC-COBS 2D-PAGEP02675; P02675.
DOSAC-COBS-2DPAGEP02675; FIBB_HUMAN.
OGP-WWWP02675.
REPRODUCTION-2DPAGEP02675; P02675.
REPRODUCTION-2DPAGEIPI00298497; IPI00298497.
Siena-2DPAGEP02675; FIBB_HUMAN.
UCD-2DPAGEP02675; FIBB_HUMAN.
UniProtKB/Swiss-ProtP02675; FIBB_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameFIBB_HUMAN
Primary accession numberP02675
Secondary accession number(s) B2R7G3 Q3KPF2
Sequence was last modified on July 1, 1993 (version 2)
Annotations were last modified on September 21, 2011 (version 150)
Name and origin of the protein
DescriptionRecName: Full=Fibrinogen beta chain; Contains: RecName: Full=Fibrinopeptide B; Contains: RecName: Full=Fibrinogen beta chain; Flags: Precursor;
Gene nameName=FGB
Encoded onName=FGB
Keywords3D-structure; Blood coagulation; Coiled coil; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Polymorphism; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLJ00129; AAA52429.1; -; mRNA
EMBLJ00131; AAA98115.1; -; Genomic_DNA
EMBLJ00130; AAA98115.1; JOINED; Genomic_DNA
EMBLJ00132; AAA98116.1; -; Genomic_DNA
EMBLJ00133; -; NOT_ANNOTATED_CDS; mRNA
EMBLM64983; AAA18024.2; -; Genomic_DNA
EMBLAF388026; AAK62470.1; -; Genomic_DNA
EMBLAK312972; BAG35810.1; -; mRNA
EMBLCH471056; EAX04932.1; -; Genomic_DNA
EMBLBC106760; AAI06761.1; -; mRNA
EMBLM26877; AAA52445.1; -; Genomic_DNA
EMBLM26876; AAA52445.1; JOINED; Genomic_DNA
EMBLX05018; CAA28674.1; -; Genomic_DNA
IPIIPI00298497; -; .
PIRB43568; FGHUB; .
RefSeqNP_001171670.1; NM_001184741.1; .
RefSeqNP_005132.2; NM_005141.4; .
UniGeneHs.300774; -; .
PDB1FZA; X-ray; 2.90 A; B/E=164-491
PDB1FZB; X-ray; 2.90 A; B/E=164-491
PDB1FZC; X-ray; 2.30 A; B/E=164-491
PDB1FZE; X-ray; 3.00 A; B/E=164-491
PDB1FZF; X-ray; 2.70 A; B/E=164-491
M/N/S/T=45-48PDB; 1FZG; X-ray; 2.50 A
B/E=164-491M/N/S/T=45-48; PDB; 1LT9; X-ray
2.80 AB/E=179-491; PDB; 1LTJ; X-ray
2.80 AB/E=179-491; PDB; 1N86; X-ray
3.20 AB/E=164-491; I/J=45-51; PDB; 1N8E
X-ray4.50 A; B/E=164-491; PDB; 1RE3
X-ray2.45 A; B/E=179-491; PDB; 1RE4
X-ray2.70 A; B/E=179-491; PDB; 1RF0
X-ray2.81 A; B/E=179-491; PDB; 1RF1
X-ray2.53 A; B/E=179-491; PDB; 2A45
X-ray3.65 A; H/K=45-135; PDB; 2FFD
X-ray2.89 A; B/E=179-491; PDB; 2H43
X-ray2.70 A; B/E=164-491; PDB; 2HLO
X-ray2.60 A; B/E=164-491; PDB; 2HOD
X-ray2.90 A; B/E/H/K=164-491; PDB; 2HPC
X-ray2.90 A; B/E/H/K=164-491; PDB; 2OYH
X-ray2.40 A; B/E=179-491; PDB; 2OYI
X-ray2.70 A; B/E=179-491; PDB; 2Q9I
X-ray2.80 A; B/E=164-491; PDB; 2XNX
X-ray3.30 A; B/E/H/K=164-491; PDB; 2XNY
X-ray7.50 A; B/E=164-491; PDB; 2Z4E
X-ray2.70 A; B/E=164-489; PDB; 3BVH
X-ray2.60 A; B/E=191-488; PDB; 3E1I
X-ray2.30 A; B/E=164-491; PDB; 3GHG
X-ray2.90 A; B/E/H/K=31-491; PDB; 3H32
X-ray3.60 A; B/E=31-488; PDB; 3HUS
X-ray3.04 A; B/E=179-491; PDBsum; 1FZA
PDBsum1FZB; -; .
PDBsum1FZC; -; .
PDBsum1FZE; -; .
PDBsum1FZF; -; .
PDBsum1FZG; -; .
PDBsum1LT9; -; .
PDBsum1LTJ; -; .
PDBsum1N86; -; .
PDBsum1N8E; -; .
PDBsum1RE3; -; .
PDBsum1RE4; -; .
PDBsum1RF0; -; .
PDBsum1RF1; -; .
PDBsum2A45; -; .
PDBsum2FFD; -; .
PDBsum2H43; -; .
PDBsum2HLO; -; .
PDBsum2HOD; -; .
PDBsum2HPC; -; .
PDBsum2OYH; -; .
PDBsum2OYI; -; .
PDBsum2Q9I; -; .
PDBsum2XNX; -; .
PDBsum2XNY; -; .
PDBsum2Z4E; -; .
PDBsum3BVH; -; .
PDBsum3E1I; -; .
PDBsum3GHG; -; .
PDBsum3H32; -; .
PDBsum3HUS; -; .
ProteinModelPortalP02675; -; .
SMRP02675; 88-488; .
DIPDIP-385N; -; .
IntActP02675; 3; .
STRINGP02675; -; .
PhosphoSiteP02675; -; .
SWISS-2DPAGEP02675; -; .
DOSAC-COBS-2DPAGEP02675; -; .
OGPP02675; -; .
REPRODUCTION-2DPAGEIPI00298497; -; .
REPRODUCTION-2DPAGEP02675; -; .
Siena-2DPAGEP02675; -; .
UCD-2DPAGEP02675; -; .
PeptideAtlasP02675; -; .
PRIDEP02675; -; .
EnsemblENST00000302068; ENSP00000306099; ENSG00000171564; .
GeneID2244; -; .
KEGGhsa:2244; -; .
UCSCuc003ioa.2; human; .
CTD2244; -; .
GeneCardsGC04P151224; -; .
H-InvDBHIX0031426; -; .
HGNCHGNC:3662; FGB; .
HPACAB008624; -; .
HPAHPA001900; -; .
HPAHPA001901; -; .
MIM134830; gene; .
MIM202400; phenotype; .
neXtProtNX_P02675; -; .
Orphanet98880; Familial afibrinogenemia; .
Orphanet98881; Familial dysfibrinogenemia; .
Orphanet248408; Familial hypodysfibrinogenemia; .
Orphanet101041; Familial hypofibrinogenemia; .
PharmGKBPA163; -; .
HOGENOMHBG717207; -; .
HOVERGENHBG005707; -; .
InParanoidP02675; -; .
OMATIHNGMF; -; .
OrthoDBEOG4WQ12K; -; .
PhylomeDBP02675; -; .
ReactomeREACT_13552; Integrin cell surface interactions; .
ReactomeREACT_604; Hemostasis; .
DrugBankDB00364; Sucralfate; .
NextBio9079; -; .
PMAP-CutDBP02675; -; .
ArrayExpressP02675; -; .
BgeeP02675; -; .
CleanExHS_FGB; -; .
GenevestigatorP02675; -; .
GermOnlineENSG00000171564; Homo sapiens; .
GOGO:0009897; C:external side of plasma membrane; IDA:BHF-UCL; .
GOGO:0005577; C:fibrinogen complex; TAS:ProtInc; .
GOGO:0031093; C:platelet alpha granule lumen; TAS:Reactome; .
GOGO:0005625; C:soluble fraction; TAS:ProtInc; .
GOGO:0051087; F:chaperone binding; IPI:BHF-UCL; .
GOGO:0043499; F:eukaryotic cell surface binding; IDA:BHF-UCL; .
GOGO:0030674; F:protein binding; bridging; IEA:InterPro
GOGO:0005102; F:receptor binding; IEA:InterPro; .
GOGO:0030168; P:platelet activation; TAS:Reactome; .
GOGO:0002576; P:platelet degranulation; TAS:Reactome; .
GOGO:0051258; P:protein polymerization; IEA:InterPro; .
GOGO:0051592; P:response to calcium ion; IDA:BHF-UCL; .
GOGO:0007165; P:signal transduction; IEA:InterPro; .
InterProIPR002181; Fibrinogen_a/b/g_C; .
InterProIPR014716; Fibrinogen_a/b/g_C_1; .
InterProIPR014715; Fibrinogen_a/b/g_C_2; .
InterProIPR012290; Fibrinogen_a/b/g_coil_dom; .
InterProIPR020837; Fibrinogen_CS; .
Gene3DG3DSA:3.90.215.10; Fibrinogen_a/b/g_C_1; 1; .
Gene3DG3DSA:4.10.530.10; Fibrinogen_a/b/g_C_2; 1; .
Gene3DG3DSA:1.20.5.50; Fibrinogen_a/b/g_coil; 1; .
PfamPF08702; Fib_alpha; 1; .
PfamPF00147; Fibrinogen_C; 1; .
SMARTSM00186; FBG; 1; .
SUPFAMSSF56496; Fibrinogen_a/b/g_C; 1; .
PROSITEPS00514; FIBRINOGEN_C_1; 1; .
PROSITEPS51406; FIBRINOGEN_C_2; 1; .



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SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server