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SWISS-2DPAGE

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It will be discontinued on 31-May-2024.

Swiss-2DPAGE data (text records and image files) will continue to be available from https://ftp.expasy.org/databases/swiss-2dpage/.


SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P04075




SWISS-2DPAGE:  P04075


P04075


General information about the entry
View entry in simple text format
Entry nameALDOA_HUMAN
Primary accession numberP04075
integrated into SWISS-2DPAGE on March 31, 2004 (release 17)
2D Annotations were last modified onMarch 31, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 5)
Name and origin of the protein
DescriptionRecName: Full=Fructose-bisphosphate aldolase A; EC=4.1.2.13; AltName: Full=Lung cancer antigen NY-LU-1; AltName: Full=Muscle-type aldolase;.
Gene nameName=ALDOA
Synonyms=ALDA
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D.
''''''New insights into HIV lymphocyte infection'';'';''
(IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004)
Comments
  • SUBUNIT: Homotetramer
2D PAGE maps for identified proteins
How to interpret a protein

LYMPHOCYTE_HUMAN {Lymphocytes}
Homo sapiens (Human)
Tissue: Lymphocyte
LYMPHOCYTE_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOCYTE_HUMAN

MAP LOCATIONS:
pI=7.89; Mw=37732  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
DOSAC-COBS 2D-PAGEP04075; P04075.
DOSAC-COBS-2DPAGEP04075; ALDOA_HUMAN.
OGP-WWWP04075.
REPRODUCTION-2DPAGEP04075; P04075.
REPRODUCTION-2DPAGEIPI00465439; IPI00465439.
Siena-2DPAGEP04075; ALDOA_HUMAN.
UCD-2DPAGEP04075; ALDOA_HUMAN.
UniProtKB/Swiss-ProtP04075; ALDOA_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameALDOA_HUMAN
Primary accession numberP04075
Secondary accession number(s) B4DXI7 Q6FH76 Q6FI10 Q96B15 Q9BWD9 Q9UCN2
Sequence was last modified on January 23, 2007 (version 2)
Annotations were last modified on October 19, 2011 (version 146)
Name and origin of the protein
DescriptionRecName: Full=Fructose-bisphosphate aldolase A; EC=4.1.2.13; AltName: Full=Lung cancer antigen NY-LU-1; AltName: Full=Muscle-type aldolase;
Gene nameName=ALDOA
Synonyms=ALDA
Encoded onName=ALDOA; Synonyms=ALDA
Keywords3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Disease mutation; Glycogen storage disease; Glycolysis; Hereditary hemolytic anemia; Lyase; Phosphoprotein; Polymorphism; Reference proteome; Schiff base.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM11560; AAA51690.1; -; mRNA
EMBLX05236; CAA28861.1; -; mRNA
EMBLX12447; CAA30979.1; ALT_SEQ; Genomic_DNA
EMBLAK301993; BAG63399.1; ALT_INIT; mRNA
EMBLCR536528; CAG38765.1; -; mRNA
EMBLCR541880; CAG46678.1; -; mRNA
EMBLCH471238; EAW79933.1; -; Genomic_DNA
EMBLBC000367; AAH00367.2; -; mRNA
EMBLBC004333; AAH04333.1; -; mRNA
EMBLBC010660; AAH10660.1; -; mRNA
EMBLBC012880; AAH12880.1; -; mRNA
EMBLBC013614; AAH13614.1; -; mRNA
EMBLBC015888; AAH15888.1; -; mRNA
EMBLBC016170; AAH16170.1; -; mRNA
EMBLBC016800; AAH16800.1; -; mRNA
EMBLM21190; AAA51697.1; -; mRNA
IPIIPI00465439; -; .
PIRS14084; ADHUA; .
RefSeqNP_000025.1; NM_000034.3; .
RefSeqNP_001121089.1; NM_001127617.2; .
RefSeqNP_001230106.1; NM_001243177.1; .
RefSeqNP_908930.1; NM_184041.2; .
RefSeqNP_908932.1; NM_184043.2; .
UniGeneHs.513490; -; .
PDB1ALD; X-ray; 2.00 A; A=2-364
PDB2ALD; X-ray; 2.10 A; A=2-364
PDB4ALD; X-ray; 2.80 A; A=2-364
PDBsum1ALD; -; .
PDBsum2ALD; -; .
PDBsum4ALD; -; .
ProteinModelPortalP04075; -; .
SMRP04075; 2-364; .
IntActP04075; 11; .
MINTMINT-4998828; -; .
STRINGP04075; -; .
PhosphoSiteP04075; -; .
SWISS-2DPAGEP04075; -; .
Aarhus/Ghent-2DPAGE1302; NEPHGE; .
DOSAC-COBS-2DPAGEP04075; -; .
OGPP04075; -; .
REPRODUCTION-2DPAGEIPI00465439; -; .
REPRODUCTION-2DPAGEP04075; -; .
Siena-2DPAGEP04075; -; .
UCD-2DPAGEP04075; -; .
PRIDEP04075; -; .
EnsemblENST00000338110; ENSP00000336927; ENSG00000149925; .
EnsemblENST00000395240; ENSP00000378661; ENSG00000149925; .
EnsemblENST00000395248; ENSP00000378669; ENSG00000149925; .
EnsemblENST00000412304; ENSP00000400452; ENSG00000149925; .
EnsemblENST00000436540; ENSP00000387793; ENSG00000149925; .
GeneID226; -; .
KEGGhsa:226; -; .
UCSCuc002dvw.1; human; .
CTD226; -; .
GeneCardsGC16P027726; -; .
H-InvDBHIX0012935; -; .
HGNCHGNC:414; ALDOA; .
HPACAB006252; -; .
HPAHPA004177; -; .
MIM103850; gene; .
MIM611881; phenotype; .
neXtProtNX_P04075; -; .
Orphanet57; Aldolase A deficiency; .
PharmGKBPA24707; -; .
eggNOGprNOG06512; -; .
GeneTreeENSGT00390000010235; -; .
HOVERGENHBG002386; -; .
InParanoidP04075; -; .
OrthoDBEOG4X3H1J; -; .
PhylomeDBP04075; -; .
BioCycMetaCyc:HS07647-MONOMER; -; .
Pathway_Interaction_DBhif1_tfpathway; HIF-1-alpha transcription factor network; .
ReactomeREACT_474; Metabolism of carbohydrates; .
ReactomeREACT_604; Hemostasis; .
NextBio920; -; .
ArrayExpressP04075; -; .
BgeeP04075; -; .
CleanExHS_ALDOA; -; .
GenevestigatorP04075; -; .
GermOnlineENSG00000149925; Homo sapiens; .
GOGO:0015629; C:actin cytoskeleton; IDA:BHF-UCL; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0070062; C:extracellular vesicular exosome; IDA:BHF-UCL; .
GOGO:0031674; C:I band; TAS:BHF-UCL; .
GOGO:0031093; C:platelet alpha granule lumen; TAS:Reactome; .
GOGO:0003779; F:actin binding; TAS:BHF-UCL; .
GOGO:0070061; F:fructose binding; IDA:BHF-UCL; .
GOGO:0004332; F:fructose-bisphosphate aldolase activity; IDA:BHF-UCL; .
GOGO:0042802; F:identical protein binding; TAS:BHF-UCL; .
GOGO:0015631; F:tubulin binding; TAS:BHF-UCL; .
GOGO:0007015; P:actin filament organization; TAS:BHF-UCL; .
GOGO:0006754; P:ATP biosynthetic process; IMP:BHF-UCL; .
GOGO:0030388; P:fructose 1; 6-bisphosphate metabolic process; IDA:BHF-UCL
GOGO:0006094; P:gluconeogenesis; TAS:Reactome; .
GOGO:0006096; P:glycolysis; IMP:BHF-UCL; .
GOGO:0046716; P:muscle cell homeostasis; IMP:BHF-UCL; .
GOGO:0030168; P:platelet activation; TAS:Reactome; .
GOGO:0002576; P:platelet degranulation; TAS:Reactome; .
GOGO:0051289; P:protein homotetramerization; ISS:UniProtKB; .
GOGO:0008360; P:regulation of cell shape; IDA:BHF-UCL; .
GOGO:0006941; P:striated muscle contraction; IMP:BHF-UCL; .
InterProIPR000741; Aldolase_I; .
InterProIPR013785; Aldolase_TIM; .
Gene3DG3DSA:3.20.20.70; Aldolase_TIM; 1; .
PANTHERPTHR11627; Aldolase_I; 1; .
PfamPF00274; Glycolytic; 1; .
PROSITEPS00158; ALDOLASE_CLASS_I; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server