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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P04264




SWISS-2DPAGE:  P04264


P04264


General information about the entry
View entry in simple text format
Entry nameK2C1_HUMAN
Primary accession numberP04264
Secondary accession number(s) Q14720
integrated into SWISS-2DPAGE on November 9, 2001 (release 15)
2D Annotations were last modified onMay 15, 2003 (version 1)
General Annotations were last modified on May 19, 2011 (version 7)
Name and origin of the protein
DescriptionRecName: Full=Keratin, type II cytoskeletal 1; AltName: Full=67 kDa cytokeratin; AltName: Full=Cytokeratin-1; Short=CK-1; AltName: Full=Hair alpha protein; AltName: Full=Keratin-1; Short=K1; AltName: Full=Type-II keratin Kb1;.
Gene nameName=KRT1
Synonyms=KRTA
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
PubMed=12429849; [NCBI, ExPASy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEOLI_HELA_2D_HUMAN {2D-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
NUCLEOLI_HELA_2D_HUMAN
  map experimental info
  protein estimated location
 
NUCLEOLI_HELA_2D_HUMAN

MAP LOCATIONS:
pI=4.92; Mw=56151  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
REPRODUCTION-2DPAGEP04264; P04264.
UniProtKB/Swiss-ProtP04264; K2C1_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameK2C1_HUMAN
Primary accession numberP04264
Secondary accession number(s) B2RA01 Q14720 Q6GSJ0 Q9H298
Sequence was last modified on May 26, 2009 (version 6)
Annotations were last modified on September 21, 2011 (version 148)
Name and origin of the protein
DescriptionRecName: Full=Keratin, type II cytoskeletal 1; AltName: Full=67 kDa cytokeratin; AltName: Full=Cytokeratin-1; Short=CK-1; AltName: Full=Hair alpha protein; AltName: Full=Keratin-1; Short=K1; AltName: Full=Type-II keratin Kb1;
Gene nameName=KRT1
Synonyms=KRTA
Encoded onName=KRT1; Synonyms=KRTA
KeywordsCell membrane; Citrullination; Coiled coil; Complete proteome; Direct protein sequencing; Disease mutation; Ichthyosis; Intermediate filament; Keratin; Membrane; Methylation; Palmoplantar keratoderma; Phosphoprotein; Polymorphism; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM98776; AAB47721.1; -; Genomic_DNA
EMBLAF237621; AAF60327.1; -; Genomic_DNA
EMBLAF304164; AAG41947.1; -; Genomic_DNA
EMBLAK313986; BAG36698.1; -; mRNA
EMBLAC055716; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLBC063697; AAH63697.1; -; mRNA
EMBLM10938; AAA36153.1; -; mRNA
IPIIPI00220327; -; .
PIRA22940; KRHU2; .
RefSeqNP_006112.3; NM_006121.3; .
UniGeneHs.80828; -; .
ProteinModelPortalP04264; -; .
SMRP04264; 178-215; 223-329; 346-491
IntActP04264; 16; .
MINTMINT-4990403; -; .
STRINGP04264; -; .
PhosphoSiteP04264; -; .
SWISS-2DPAGEP04264; -; .
Aarhus/Ghent-2DPAGE4606; NEPHGE; .
REPRODUCTION-2DPAGEP04264; -; .
PRIDEP04264; -; .
EnsemblENST00000252244; ENSP00000252244; ENSG00000167768; .
GeneID3848; -; .
KEGGhsa:3848; -; .
CTD3848; -; .
GeneCardsGC12M050112; -; .
H-InvDBHIX0036813; -; .
HGNCHGNC:6412; KRT1; .
HPACAB002153; -; .
HPAHPA017917; -; .
MIM113800; phenotype; .
MIM139350; gene; .
MIM146590; phenotype; .
MIM600962; phenotype; .
MIM607602; phenotype; .
MIM607654; phenotype; .
neXtProtNX_P04264; -; .
Orphanet312; Congenital bullous ichthyosiform erythroderma; .
Orphanet79503; Ichthyosis hystrix; Curth-Macklin type; .
Orphanet50942; Keratosis palmoplantaris striata; .
Orphanet313; Lamellar ichthyosis; .
Orphanet2199; Localized epidermolytic palmoplantar hyperkeratosis; .
Orphanet496; Thost-Unna palmoplantar keratoderma; .
PharmGKBPA30199; -; .
eggNOGprNOG11445; -; .
GeneTreeENSGT00550000074491; -; .
HOGENOMHBG715391; -; .
HOVERGENHBG013015; -; .
InParanoidP04264; -; .
OMAINYQRRT; -; .
OrthoDBEOG48GW3H; -; .
PhylomeDBP04264; -; .
NextBio15141; -; .
ArrayExpressP04264; -; .
BgeeP04264; -; .
CleanExHS_KRT1; -; .
GenevestigatorP04264; -; .
GermOnlineENSG00000167768; Homo sapiens; .
GOGO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell; .
GOGO:0005515; F:protein binding; IPI:UniProtKB; .
GOGO:0004872; F:receptor activity; NAS:UniProtKB; .
GOGO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc; .
GOGO:0005529; F:sugar binding; IPI:UniProtKB; .
GOGO:0001867; P:complement activation; lectin pathway; IPI:UniProtKB
GOGO:0008544; P:epidermis development; TAS:ProtInc; .
GOGO:0042730; P:fibrinolysis; NAS:UniProtKB; .
GOGO:0045765; P:regulation of angiogenesis; NAS:UniProtKB; .
GOGO:0006979; P:response to oxidative stress; NAS:UniProtKB; .
InterProIPR016044; F; .
InterProIPR001664; IF; .
InterProIPR018039; Intermediate_filament_CS; .
InterProIPR003054; Keratin_II; .
InterProIPR009053; Prefoldin; .
PANTHERPTHR23239; IF; 1; .
PANTHERPTHR23239:SF18; Keratin_II; 1; .
PfamPF00038; Filament; 1; .
PRINTSPR01276; TYPE2KERATIN; .
SUPFAMSSF46579; Prefoldin; 1; .
PROSITEPS00226; IF; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server