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Sample Preparation and Post-separation Analysis Searching in 'SWISS-2DPAGE' for entry matching: P04264 SWISS-2DPAGE:  P04264 P04264 General information about the entry View entry in simple text format Entry name K2C1_HUMAN Primary accession number P04264 Secondary accession number(s) Q14720 integrated into SWISS-2DPAGE on  November 9, 2001 (release 15) 2D Annotations were last modified on May 15, 2003 (version 1) General Annotations were last modified on  May 19, 2011 (version 7) Name and origin of the protein Description RecName: Full=Keratin, type II cytoskeletal 1; AltName: Full=67 kDa cytokeratin; AltName: Full=Cytokeratin-1; Short=CK-1; AltName: Full=Hair alpha protein; AltName: Full=Keratin-1; Short=K1; AltName: Full=Type-II keratin Kb1;. Gene name Name=KRT1 Synonyms=KRTA Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   MAPPING ON GEL PubMed=12429849; [NCBI, Expasy, EBI, Israel, Japan] Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J. ''''''Functional proteomic analysis of human nucleolus'';'';'' Mol. Biol. Cell. 13(1):4100-4109(2002) 2D PAGE maps for identified proteins How to interpret a protein NUCLEOLI_HELA_2D_HUMAN {2D-PAGE of nucleolar proteins from Human HeLa cells} Homo sapiens (Human) Tissue: Cervix carcinoma   map experimental info   protein estimated location   NUCLEOLI_HELA_2D_HUMAN MAP LOCATIONS: SPOT 2D-001VK9: pI=4.92; Mw=56151   [identification data] MAPPING (identification): Peptide mass fingerprinting [1]. Copyright This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). Cross-references REPRODUCTION-2DPAGE P04264; P04264. UniProtKB/Swiss-Prot P04264; K2C1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_10 Entry name K2C1_HUMAN Primary accession number P04264 Secondary accession number(s) B2RA01 Q14720 Q6GSJ0 Q9H298 Sequence was last modified on  May 26, 2009 (version 6) Annotations were last modified on  September 21, 2011 (version 148) Name and origin of the protein Description RecName: Full=Keratin, type II cytoskeletal 1; AltName: Full=67 kDa cytokeratin; AltName: Full=Cytokeratin-1; Short=CK-1; AltName: Full=Hair alpha protein; AltName: Full=Keratin-1; Short=K1; AltName: Full=Type-II keratin Kb1; Gene name Name=KRT1 Synonyms=KRTA Encoded on Name=KRT1; Synonyms=KRTA Keywords Cell membrane; Citrullination; Coiled coil; Complete proteome; Direct protein sequencing; Disease mutation; Ichthyosis; Intermediate filament; Keratin; Membrane; Methylation; Palmoplantar keratoderma; Phosphoprotein; Polymorphism; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M98776; AAB47721.1; -; Genomic_DNA EMBL AF237621; AAF60327.1; -; Genomic_DNA EMBL AF304164; AAG41947.1; -; Genomic_DNA EMBL AK313986; BAG36698.1; -; mRNA EMBL AC055716; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC063697; AAH63697.1; -; mRNA EMBL M10938; AAA36153.1; -; mRNA IPI IPI00220327; -; . PIR A22940; KRHU2; . RefSeq NP_006112.3; NM_006121.3; . UniGene Hs.80828; -; . ProteinModelPortal P04264; -; . SMR P04264; 178-215; 223-329; 346-491 IntAct P04264; 16; . MINT MINT-4990403; -; . STRING P04264; -; . PhosphoSite P04264; -; . SWISS-2DPAGE P04264; -; . Aarhus/Ghent-2DPAGE 4606; NEPHGE; . REPRODUCTION-2DPAGE P04264; -; . PRIDE P04264; -; . Ensembl ENST00000252244; ENSP00000252244; ENSG00000167768; . GeneID 3848; -; . KEGG hsa:3848; -; . CTD 3848; -; . GeneCards GC12M050112; -; . H-InvDB HIX0036813; -; . HGNC HGNC:6412; KRT1; . HPA CAB002153; -; . HPA HPA017917; -; . MIM 113800; phenotype; . MIM 139350; gene; . MIM 146590; phenotype; . MIM 600962; phenotype; . MIM 607602; phenotype; . MIM 607654; phenotype; . neXtProt NX_P04264; -; . Orphanet 312; Congenital bullous ichthyosiform erythroderma; . Orphanet 79503; Ichthyosis hystrix; Curth-Macklin type; . Orphanet 50942; Keratosis palmoplantaris striata; . Orphanet 313; Lamellar ichthyosis; . Orphanet 2199; Localized epidermolytic palmoplantar hyperkeratosis; . Orphanet 496; Thost-Unna palmoplantar keratoderma; . PharmGKB PA30199; -; . eggNOG prNOG11445; -; . GeneTree ENSGT00550000074491; -; . HOGENOM HBG715391; -; . HOVERGEN HBG013015; -; . InParanoid P04264; -; . OMA INYQRRT; -; . OrthoDB EOG48GW3H; -; . PhylomeDB P04264; -; . NextBio 15141; -; . ArrayExpress P04264; -; . Bgee P04264; -; . CleanEx HS_KRT1; -; . Genevestigator P04264; -; . GermOnline ENSG00000167768; Homo sapiens; . GO GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0004872; F:receptor activity; NAS:UniProtKB; . GO GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc; . GO GO:0005529; F:sugar binding; IPI:UniProtKB; . GO GO:0001867; P:complement activation; lectin pathway; IPI:UniProtKB GO GO:0008544; P:epidermis development; TAS:ProtInc; . GO GO:0042730; P:fibrinolysis; NAS:UniProtKB; . GO GO:0045765; P:regulation of angiogenesis; NAS:UniProtKB; . GO GO:0006979; P:response to oxidative stress; NAS:UniProtKB; . InterPro IPR016044; F; . InterPro IPR001664; IF; . InterPro IPR018039; Intermediate_filament_CS; . InterPro IPR003054; Keratin_II; . InterPro IPR009053; Prefoldin; . PANTHER PTHR23239; IF; 1; . PANTHER PTHR23239:SF18; Keratin_II; 1; . Pfam PF00038; Filament; 1; . PRINTS PR01276; TYPE2KERATIN; . SUPFAM SSF46579; Prefoldin; 1; . PROSITE PS00226; IF; 1; . SWISS-2DPAGE (search AC)