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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P05783




SWISS-2DPAGE:  P05783


P05783


General information about the entry
View entry in simple text format
Entry nameK1C18_HUMAN
Primary accession numberP05783
integrated into SWISS-2DPAGE on January 15, 1999 (release 9)
2D Annotations were last modified onMay 15, 2003 (version 3)
General Annotations were last modified on May 19, 2011 (version 9)
Name and origin of the protein
DescriptionRecName: Full=Keratin, type I cytoskeletal 18; AltName: Full=Cell proliferation-inducing gene 46 protein; AltName: Full=Cytokeratin-18; Short=CK-18; AltName: Full=Keratin-18; Short=K18;.
Gene nameName=KRT18
Synonyms=CYK18
ORFNames=PIG46
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
[2]   MAPPING ON GEL
MEDLINE=20529951; PubMed=11079567; [NCBI, ExPASy, EBI, Israel, Japan]
Jung E., Hoogland C., Chiappe D., Sanchez J.-C., Hochstrasser D.F.
''''''The establishment of a human liver nuclei 2-DE reference map'';'';''
Electrophoresis 21(1):3483-3487(2000)
[3]   MAPPING ON GEL
PubMed=12429849; [NCBI, ExPASy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
2D PAGE maps for identified proteins
How to interpret a protein

DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
DLD1_HUMAN
  map experimental info
  protein estimated location
 
DLD1_HUMAN

MAP LOCATIONS:
pI=5.25; Mw=43007  [identification data]
pI=5.15; Mw=43228  [identification data]
pI=5.19; Mw=43007  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].



NUCLEI_LIVER_HUMAN {Soluble nuclear proteins and matrix from liver tissue}
Homo sapiens (Human)
Tissue: Liver
NUCLEI_LIVER_HUMAN
  map experimental info
  protein estimated location
 
NUCLEI_LIVER_HUMAN

MAP LOCATIONS:
pI=5.44; Mw=42868  [identification data]
pI=5.34; Mw=42868  [identification data]
pI=4.96; Mw=39878  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [2].



NUCLEOLI_HELA_2D_HUMAN {2D-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
NUCLEOLI_HELA_2D_HUMAN
  map experimental info
  protein estimated location
 
NUCLEOLI_HELA_2D_HUMAN

MAP LOCATIONS:
pI=5.59; Mw=45837  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [3].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
PMMA-2DPAGEP05783; K1CR_HUMAN.
Siena-2DPAGEP05783; K1C18_HUMAN.
UniProtKB/Swiss-ProtP05783; K1C18_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameK1C18_HUMAN
Primary accession numberP05783
Secondary accession number(s) Q53G38 Q5U0N8 Q9BW26
Sequence was last modified on January 23, 2007 (version 2)
Annotations were last modified on October 19, 2011 (version 138)
Name and origin of the protein
DescriptionRecName: Full=Keratin, type I cytoskeletal 18; AltName: Full=Cell proliferation-inducing gene 46 protein; AltName: Full=Cytokeratin-18; Short=CK-18; AltName: Full=Keratin-18; Short=K18;
Gene nameName=KRT18
Synonyms=CYK18
ORFNames=PIG46
Encoded onName=KRT18; Synonyms=CYK18; ORFNames=PIG46
KeywordsAcetylation; Cell cycle; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Glycoprotein; Host-virus interaction; Intermediate filament; Keratin; Phosphoprotein; Polymorphism; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX12881; CAA31375.1; -; mRNA
EMBLAY762101; AAX07828.1; -; mRNA
EMBLBT019412; AAV38219.1; -; mRNA
EMBLAK223093; BAD96813.1; -; mRNA
EMBLBC000180; AAH00180.1; -; mRNA
EMBLBC000698; AAH00698.1; -; mRNA
EMBLBC004253; AAH04253.1; -; mRNA
EMBLBC008636; AAH08636.1; -; mRNA
EMBLBC020982; AAH20982.1; -; mRNA
EMBLBC072017; AAH72017.1; -; mRNA
EMBLAF179904; AAA59461.1; -; Genomic_DNA
EMBLX12883; CAA31377.1; -; mRNA
EMBLX12876; CAA31369.1; -; mRNA
IPIIPI00554788; -; .
PIRS05481; S05481; .
RefSeqNP_000215.1; NM_000224.2; .
RefSeqNP_954657.1; NM_199187.1; .
UniGeneHs.406013; -; .
ProteinModelPortalP05783; -; .
SMRP05783; 78-115; 122-227; 244-389
DIPDIP-633N; -; .
IntActP05783; 21; .
MINTMINT-215967; -; .
STRINGP05783; -; .
GlycoSuiteDBP05783; -; .
PhosphoSiteP05783; -; .
SWISS-2DPAGEP05783; -; .
PMMA-2DPAGEP05783; -; .
Siena-2DPAGEP05783; -; .
PRIDEP05783; -; .
EnsemblENST00000388835; ENSP00000373487; ENSG00000111057; .
EnsemblENST00000388837; ENSP00000373489; ENSG00000111057; .
GeneID3875; -; .
KEGGhsa:3875; -; .
UCSCuc001sbe.1; human; .
CTD3875; -; .
GeneCardsGC12P050386; -; .
H-InvDBHIX0010657; -; .
H-InvDBHIX0040371; -; .
H-InvDBHIX0201451; -; .
HGNCHGNC:6430; KRT18; .
HPACAB000008; -; .
HPACAB000030; -; .
HPACAB000092; -; .
HPAHPA001605; -; .
MIM148070; gene; .
MIM215600; phenotype; .
neXtProtNX_P05783; -; .
PharmGKBPA30217; -; .
eggNOGprNOG04351; -; .
GeneTreeENSGT00560000076905; -; .
HOGENOMHBG715391; -; .
HOVERGENHBG013015; -; .
InParanoidP05783; -; .
OMAKGLQNQI; -; .
OrthoDBEOG4RV2S1; -; .
Pathway_Interaction_DBcaspase_pathway; Caspase cascade in apoptosis; .
NextBio15217; -; .
PMAP-CutDBP05783; -; .
ArrayExpressP05783; -; .
BgeeP05783; -; .
CleanExHS_KRT18; -; .
GenevestigatorP05783; -; .
GermOnlineENSG00000111057; Homo sapiens; .
GOGO:0034451; C:centriolar satellite; IDA:BHF-UCL; .
GOGO:0045095; C:keratin filament; IDA:UniProtKB; .
GOGO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell; .
GOGO:0005515; F:protein binding; IPI:UniProtKB; .
GOGO:0005198; F:structural molecule activity; IEA:InterPro; .
GOGO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc; .
GOGO:0007049; P:cell cycle; IEA:UniProtKB-KW; .
GOGO:0043000; P:Golgi to plasma membrane CFTR protein transport; IDA:UniProtKB; .
GOGO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW; .
GOGO:0043066; P:negative regulation of apoptosis; IDA:UniProtKB; .
InterProIPR016044; F; .
InterProIPR001664; IF; .
InterProIPR018039; Intermediate_filament_CS; .
InterProIPR002957; Keratin_I; .
PANTHERPTHR23239; IF; 1; .
PfamPF00038; Filament; 1; .
PRINTSPR01248; TYPE1KERATIN; .
PROSITEPS00226; IF; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server