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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: P05787



General information about the entry
View entry in simple text format
Entry nameK2C8_HUMAN
Primary accession numberP05787
integrated into SWISS-2DPAGE on January 15, 1999 (release 9)
2D Annotations were last modified onMay 15, 2003 (version 4)
General Annotations were last modified on May 19, 2011 (version 9)
Name and origin of the protein
DescriptionRecName: Full=Keratin, type II cytoskeletal 8; AltName: Full=Cytokeratin-8; Short=CK-8; AltName: Full=Keratin-8; Short=K8; AltName: Full=Type-II keratin Kb8;.
Gene nameName=KRT8
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
MEDLINE=20529951; PubMed=11079567; [NCBI, ExPASy, EBI, Israel, Japan]
Jung E., Hoogland C., Chiappe D., Sanchez J.-C., Hochstrasser D.F.
''''''The establishment of a human liver nuclei 2-DE reference map'';'';''
Electrophoresis 21(1):3483-3487(2000)
PubMed=12429849; [NCBI, ExPASy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEOLI_HELA_1D_HUMAN {SDS-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
  map experimental info
  protein estimated location

Mw=53744  [identification data]

MAPPING (identification):
Tandem mass spectrometry [3].

DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
  map experimental info
  protein estimated location

pI=5.11; Mw=43451  [identification data]
pI=5.04; Mw=41700  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].

NUCLEI_LIVER_HUMAN {Soluble nuclear proteins and matrix from liver tissue}
Homo sapiens (Human)
Tissue: Liver
  map experimental info
  protein estimated location

pI=5.62; Mw=50410  [identification data]
pI=5.74; Mw=49414  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [2].

NUCLEOLI_HELA_2D_HUMAN {2D-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
  map experimental info
  protein estimated location

pI=5.86; Mw=53474  [identification data]

MAPPING (identification):
Peptide mass fingerprinting and tandem mass spectrometry [3].

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
Siena-2DPAGEP05787; K2C8_HUMAN.
UniProtKB/Swiss-ProtP05787; K2C8_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameK2C8_HUMAN
Primary accession numberP05787
Secondary accession number(s) A8K4H3 B0AZN5 Q14099 Q14716 Q14717 Q53GJ0 Q6DHW5 Q6GMY0 Q6P4C7 Q96J60
Sequence was last modified on January 23, 2007 (version 7)
Annotations were last modified on October 19, 2011 (version 148)
Name and origin of the protein
DescriptionRecName: Full=Keratin, type II cytoskeletal 8; AltName: Full=Cytokeratin-8; Short=CK-8; AltName: Full=Keratin-8; Short=K8; AltName: Full=Type-II keratin Kb8;
Gene nameName=KRT8
Encoded onName=KRT8; Synonyms=CYK8
KeywordsAcetylation; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Glycoprotein; Host-virus interaction; Intermediate filament; Keratin; Nucleus; Phosphoprotein; Polymorphism; Reference proteome.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLM34482; AAA35763.1; -; Genomic_DNA
EMBLM34225; AAA35748.1; -; mRNA
EMBLX74929; CAA52882.1; -; mRNA
EMBLX74981; CAA52916.1; -; Genomic_DNA
EMBLU76549; AAB18966.1; -; mRNA
EMBLAK222941; BAD96661.1; -; mRNA
EMBLAK290938; BAF83627.1; -; mRNA
EMBLAK315826; BAF98717.1; -; mRNA
EMBLCH471054; EAW96653.1; -; Genomic_DNA
EMBLBC000654; AAH00654.3; -; mRNA
EMBLBC063513; AAH63513.2; -; mRNA
EMBLBC073760; AAH73760.1; -; mRNA
EMBLBC075839; AAH75839.1; -; mRNA
EMBLM26512; AAA51542.1; -; mRNA
EMBLX12882; CAA31376.1; -; mRNA
EMBLX98614; CAA67203.1; -; mRNA
IPIIPI00554648; -; .
PIRA34720; A34720; .
RefSeqNP_002264.1; NM_002273.3; .
UniGeneHs.533782; -; .
UniGeneHs.708445; -; .
ProteinModelPortalP05787; -; .
SMRP05787; 89-126; 131-238; 255-400
DIPDIP-424N; -; .
IntActP05787; 9; .
MINTMINT-256526; -; .
STRINGP05787; -; .
GlycoSuiteDBP05787; -; .
PhosphoSiteP05787; -; .
SWISS-2DPAGEP05787; -; .
Siena-2DPAGEP05787; -; .
PeptideAtlasP05787; -; .
PRIDEP05787; -; .
EnsemblENST00000293308; ENSP00000293308; ENSG00000170421; .
GeneID3856; -; .
KEGGhsa:3856; -; .
UCSCuc001sbd.1; human; .
CTD3856; -; .
GeneCardsGC12M050334; -; .
H-InvDBHIX0010658; -; .
H-InvDBHIX0026255; -; .
H-InvDBHIX0034365; -; .
HGNCHGNC:6446; KRT8; .
HPACAB000131; -; .
HPACAB001696; -; .
MIM148060; gene; .
MIM215600; phenotype; .
neXtProtNX_P05787; -; .
PharmGKBPA30234; -; .
eggNOGprNOG14428; -; .
HOVERGENHBG013015; -; .
InParanoidP05787; -; .
OrthoDBEOG4XKV78; -; .
PhylomeDBP05787; -; .
Pathway_Interaction_DBp38alphabetadownstreampathway; Signaling mediated by p38-alpha and p38-beta; .
DrugBankDB00009; Alteplase; .
DrugBankDB00029; Anistreplase; .
DrugBankDB00015; Reteplase; .
DrugBankDB00031; Tenecteplase; .
NextBio15173; -; .
PMAP-CutDBP05787; -; .
ArrayExpressP05787; -; .
BgeeP05787; -; .
GenevestigatorP05787; -; .
GermOnlineENSG00000170421; Homo sapiens; .
GOGO:0005737; C:cytoplasm; IDA:UniProtKB; .
GOGO:0045095; C:keratin filament; IEA:InterPro; .
GOGO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell; .
GOGO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell; .
GOGO:0005515; F:protein binding; IPI:UniProtKB; .
GOGO:0005198; F:structural molecule activity; NAS:UniProtKB; .
GOGO:0007010; P:cytoskeleton organization; NAS:UniProtKB; .
GOGO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW; .
InterProIPR016044; F; .
InterProIPR001664; IF; .
InterProIPR018039; Intermediate_filament_CS; .
InterProIPR003054; Keratin_II; .
PANTHERPTHR23239; IF; 1; .
PANTHERPTHR23239:SF18; Keratin_II; 1; .
PfamPF00038; Filament; 1; .
PROSITEPS00226; IF; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server