General information about the entry |
View entry in simple text format |
Entry name | CDK1_HUMAN |
Primary accession number | P06493 |
integrated into SWISS-2DPAGE on | September 1, 1997 (release 6) |
2D Annotations were last modified on | December 30, 2004 (version 1) |
General Annotations were last modified on | November 9, 2011 (version 14) |
Name and origin of the protein |
Description | RecName: Full=Cyclin-dependent kinase 1; Short=CDK1; EC=2.7.11.22; EC=2.7.11.23; AltName: Full=Cell division control protein 2 homolog; AltName: Full=Cell division protein kinase 1; AltName: Full=p34 protein kinase;. |
Gene name | Name=CDK1 Synonyms=CDC2, CDC28A, CDKN1, P34CDC2
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Annotated species | Homo sapiens (Human) [TaxID: 9606] |
Taxonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
References |
[1] |
MAPPING ON GEL MEDLINE=97295311; PubMed=9150953; [NCBI, Expasy, EBI, Israel, Japan]
Sanchez J.-C., Wirth P., Jaccoud S., Appel R.D., Sarto C., Wilkins M.R., Hochstrasser D.F. ''''''Simultaneous analysis of cyclin and oncogene expression using multiple monoclonal antibody immunoblots'';'';'' Electrophoresis 18(1):638-641(1997)
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2D PAGE maps for identified proteins
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How to interpret a protein
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HEPG2_HUMAN {HepG2} Homo sapiens (Human)
Tissue: Hepatoblastoma
map experimental info protein estimated location
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HEPG2_HUMAN
MAP LOCATIONS:
MAPPING (identification): IMMUNOBLOTTING [1].
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Copyright |
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). |
Cross-references |
UniProtKB/Swiss-Prot | P06493; CDK1_HUMAN. |
2D PAGE maps for identified proteins
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- How to interpret a protein map
- You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
- Warning 1: the displayed region reflects
an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information.
It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
- Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
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External data extracted from UniProtKB/Swiss-Prot |
Extracted from UniProtKB/Swiss-Prot, release: 2011_10 |
Entry name | CDK1_HUMAN |
Primary accession number | P06493 |
Secondary accession number(s) | A8K7C4 C9J497 O60764 |
Sequence was last modified on | May 31, 2011 (version 3) |
Annotations were last modified on | October 19, 2011 (version 159) |
Name and origin of the protein |
Description | RecName: Full=Cyclin-dependent kinase 1; Short=CDK1; EC=2.7.11.22; EC=2.7.11.23; AltName: Full=Cell division control protein 2 homolog; AltName: Full=Cell division protein kinase 1; AltName: Full=p34 protein kinase; |
Gene name | Name=CDK1 Synonyms=CDC2, CDC28A, CDKN1, P34CDC2 |
Encoded on | Name=CDK1; Synonyms=CDC2, CDC28A, CDKN1, P34CDC2 |
Keywords | 3D-structure; Acetylation; Alternative splicing; Apoptosis; ATP-binding; Cell cycle; Cell division; Complete proteome; Cytoplasm; Isopeptide bond; Kinase; Mitochondrion; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Ubl conjugation. |
Copyright |
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License |
Cross-references |
EMBL | X05360; CAA28963.1; -; mRNA |
EMBL | Y00272; CAA68376.1; -; mRNA |
EMBL | D88357; BAA26001.1; -; mRNA |
EMBL | AK291939; BAF84628.1; -; mRNA |
EMBL | BT007004; AAP35650.1; -; mRNA |
EMBL | AF512554; AAM34793.1; -; Genomic_DNA |
EMBL | AC022390; -; NOT_ANNOTATED_CDS; Genomic_DNA |
EMBL | CH471083; EAW54204.1; ALT_SEQ; Genomic_DNA |
EMBL | BC014563; AAH14563.1; -; mRNA |
IPI | IPI00026689; -; . |
IPI | IPI00073536; -; . |
PIR | A29539; A29539; . |
RefSeq | NP_001777.1; NM_001786.4; . |
RefSeq | NP_203698.1; NM_033379.4; . |
UniGene | Hs.334562; -; . |
PDB | 1LC9; Model; -; A=1-297 |
PDBsum | 1LC9; -; . |
ProteinModelPortal | P06493; -; . |
SMR | P06493; 1-289; . |
DIP | DIP-35N; -; . |
IntAct | P06493; 31; . |
MINT | MINT-5000894; -; . |
STRING | P06493; -; . |
PhosphoSite | P06493; -; . |
SWISS-2DPAGE | P06493; -; . |
PRIDE | P06493; -; . |
Ensembl | ENST00000395284; ENSP00000378699; ENSG00000170312; . |
GeneID | 983; -; . |
KEGG | hsa:983; -; . |
UCSC | uc001jld.1; human; . |
UCSC | uc001jlg.1; human; . |
CTD | 983; -; . |
GeneCards | GC10P056527; -; . |
H-InvDB | HIX0008851; -; . |
HGNC | HGNC:1722; CDK1; . |
HPA | CAB003799; -; . |
HPA | HPA003387; -; . |
MIM | 116940; gene; . |
neXtProt | NX_P06493; -; . |
PharmGKB | PA99; -; . |
eggNOG | prNOG11741; -; . |
HOVERGEN | HBG014652; -; . |
OMA | PNNDVWP; -; . |
OrthoDB | EOG41NTMH; -; . |
PhylomeDB | P06493; -; . |
BRENDA | 2.7.11.22; 2681; . |
Pathway_Interaction_DB | foxm1pathway; FOXM1 transcription factor network; . |
Pathway_Interaction_DB | retinoic_acid_pathway; Retinoic acid receptors-mediated signaling; . |
Reactome | REACT_11061; Signalling by NGF; . |
Reactome | REACT_152; Cell Cycle; Mitotic; . |
Reactome | REACT_1538; Cell Cycle Checkpoints; . |
Reactome | REACT_16888; Signaling by PDGF; . |
Reactome | REACT_18266; Axon guidance; . |
Reactome | REACT_498; Signaling by Insulin receptor; . |
Reactome | REACT_6850; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; . |
Reactome | REACT_6900; Immune System; . |
Reactome | REACT_9417; Signaling by EGFR; . |
BindingDB | P06493; -; . |
NextBio | 4122; -; . |
ArrayExpress | P06493; -; . |
Bgee | P06493; -; . |
CleanEx | HS_CDC2; -; . |
Genevestigator | P06493; -; . |
GermOnline | ENSG00000170312; Homo sapiens; . |
GO | GO:0005829; C:cytosol; TAS:Reactome; . |
GO | GO:0030496; C:midbody; IDA:UniProtKB; . |
GO | GO:0005654; C:nucleoplasm; TAS:Reactome; . |
GO | GO:0005876; C:spindle microtubule; IDA:UniProtKB; . |
GO | GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . |
GO | GO:0004693; F:cyclin-dependent protein kinase activity; IDA:UniProtKB; . |
GO | GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IDA:UniProtKB; . |
GO | GO:0000187; P:activation of MAPK activity; TAS:Reactome; . |
GO | GO:0000186; P:activation of MAPKK activity; TAS:Reactome; . |
GO | GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; . |
GO | GO:0006916; P:anti-apoptosis; IDA:UniProtKB; . |
GO | GO:0007411; P:axon guidance; TAS:Reactome; . |
GO | GO:0051301; P:cell division; IEA:UniProtKB-KW; . |
GO | GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome; . |
GO | GO:0045087; P:innate immune response; TAS:Reactome; . |
GO | GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome; . |
GO | GO:0007067; P:mitosis; IEA:UniProtKB-KW; . |
GO | GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome; . |
GO | GO:0002756; P:MyD88-independent toll-like receptor signaling pathway; TAS:Reactome; . |
GO | GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome; . |
GO | GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; . |
GO | GO:0034501; P:protein localization to kinetochore; IDA:BHF-UCL; . |
GO | GO:0007265; P:Ras protein signal transduction; TAS:Reactome; . |
GO | GO:0000083; P:regulation of transcription involved in G1/S phase of mitotic cell cycle; TAS:Reactome; . |
GO | GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome; . |
GO | GO:0008063; P:Toll signaling pathway; TAS:Reactome; . |
GO | GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome; . |
GO | GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome; . |
GO | GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome; . |
GO | GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome; . |
InterPro | IPR011009; Kinase-like_dom; . |
InterPro | IPR000719; Prot_kinase_cat_dom; . |
InterPro | IPR017441; Protein_kinase_ATP_BS; . |
InterPro | IPR017442; Se/Thr_kinase-like_dom; . |
InterPro | IPR008271; Ser/Thr_kinase_AS; . |
InterPro | IPR002290; Ser/Thr_kinase_dom; . |
Pfam | PF00069; Pkinase; 1; . |
SMART | SM00220; S_TKc; 1; . |
SUPFAM | SSF56112; Kinase_like; 1; . |
PROSITE | PS00107; PROTEIN_KINASE_ATP; 1; . |
PROSITE | PS50011; PROTEIN_KINASE_DOM; 1; . |
PROSITE | PS00108; PROTEIN_KINASE_ST; 1; . |