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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: P16070



General information about the entry
View entry in simple text format
Entry nameCD44_HUMAN
Primary accession numberP16070
integrated into SWISS-2DPAGE on September 1, 1997 (release 6)
2D Annotations were last modified onDecember 1, 2000 (version 2)
General Annotations were last modified on May 19, 2011 (version 10)
Name and origin of the protein
DescriptionRecName: Full=CD44 antigen; AltName: Full=CDw44; AltName: Full=Epican; AltName: Full=Extracellular matrix receptor III; Short=ECMR-III; AltName: Full=GP90 lymphocyte homing/adhesion receptor; AltName: Full=HUTCH-I; AltName: Full=Heparan sulfate proteoglycan; AltName: Full=Hermes antigen; AltName: Full=Hyaluronate receptor; AltName: Full=Phagocytic glycoprotein 1; Short=PGP-1; AltName: Full=Phagocytic glycoprotein I; Short=PGP-I; AltName: CD_antigen=CD44; Flags: Precursor;.
Gene nameName=CD44
Synonyms=LHR, MDU2, MDU3, MIC4
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
MEDLINE=98163346; PubMed=9504818; [NCBI, Expasy, EBI, Israel, Japan]
Reymond M.A., Sanchez J.-C., Hughes G.J., Riese J., Tortola S., Peinado M.A., Kirchner T., Hohenberger W., Hochstrasser D.F., Kockerling F.
''''''Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis'';'';''
Electrophoresis 18(1):2842-2848(1997)
MEDLINE=96024065; PubMed=7553660; [NCBI, Expasy, EBI, Israel, Japan]
Gunthert U., Stauder R., Mayer B., Terpe H.J., Finke L., Friedrichs K.
''''''Are CD44 variant isoforms involved in human tumour progression?'';'';''
Cancer Surv. 24(1):19-42(1995)
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
2D PAGE maps for identified proteins
How to interpret a protein

CEC_HUMAN {Colorectal epithelia cells}
Homo sapiens (Human)
Tissue: Colon epithelium
  map experimental info
  protein estimated location

pI=5.06; Mw=43699
pI=5.23; Mw=43168
pI=5.11; Mw=42731


MAPPING (identification):

DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
  map experimental info
  protein estimated location

pI=5.16; Mw=75169
pI=5.25; Mw=75561
pI=5.21; Mw=74392

MAPPING (identification):

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
UniProtKB/Swiss-ProtP16070; CD44_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameCD44_HUMAN
Primary accession numberP16070
Secondary accession number(s) A5YRN9 D3DR12 D3DR13 P22511 Q04858 Q13419 Q13957 Q13958 Q13959 Q13960 Q13961 Q13967 Q13968 Q13980 Q15861 Q16064 Q16065 Q16066 Q16208 Q16522 Q86T72 Q86Z27 Q8N694 Q92493 Q96J24 Q9H5A5 Q9UC28 Q9UC29 Q9UC30 Q9UCB0 Q9UJ36
Sequence was last modified on October 5, 2010 (version 3)
Annotations were last modified on September 21, 2011 (version 152)
Name and origin of the protein
DescriptionRecName: Full=CD44 antigen; AltName: Full=CDw44; AltName: Full=Epican; AltName: Full=Extracellular matrix receptor III; Short=ECMR-III; AltName: Full=GP90 lymphocyte homing/adhesion receptor; AltName: Full=HUTCH-I; AltName: Full=Heparan sulfate proteoglycan; AltName: Full=Hermes antigen; AltName: Full=Hyaluronate receptor; AltName: Full=Phagocytic glycoprotein 1; Short=PGP-1; AltName: Full=Phagocytic glycoprotein I; Short=PGP-I; AltName: CD_antigen=CD44; Flags: Precursor;
Gene nameName=CD44
Synonyms=LHR, MDU2, MDU3, MIC4
Encoded onName=CD44; Synonyms=LHR, MDU2, MDU3, MIC4
Keywords3D-structure; Alternative splicing; Blood group antigen; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Proteoglycan; Pyrrolidone carboxylic acid; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLM24915; AAA35674.1; -; mRNA
EMBLM59040; AAA51950.1; -; mRNA
EMBLX55150; CAA38951.1; -; mRNA
EMBLX56794; CAA40133.1; -; mRNA
EMBLX66733; CAA47271.1; -; mRNA
EMBLL05423; AAB13622.1; -; Genomic_DNA
EMBLL05407; AAB13622.1; JOINED; Genomic_DNA
EMBLL05408; AAB13622.1; JOINED; Genomic_DNA
EMBLL05409; AAB13622.1; JOINED; Genomic_DNA
EMBLL05410; AAB13622.1; JOINED; Genomic_DNA
EMBLL05420; AAB13622.1; JOINED; Genomic_DNA
EMBLL05421; AAB13622.1; JOINED; Genomic_DNA
EMBLL05422; AAB13622.1; JOINED; Genomic_DNA
EMBLM69215; AAB13622.1; JOINED; Genomic_DNA
EMBLL05423; AAB13623.1; -; Genomic_DNA
EMBLL05407; AAB13623.1; JOINED; Genomic_DNA
EMBLL05408; AAB13623.1; JOINED; Genomic_DNA
EMBLL05410; AAB13623.1; JOINED; Genomic_DNA
EMBLL05411; AAB13623.1; JOINED; Genomic_DNA
EMBLL05412; AAB13623.1; JOINED; Genomic_DNA
EMBLL05414; AAB13623.1; JOINED; Genomic_DNA
EMBLL05415; AAB13623.1; JOINED; Genomic_DNA
EMBLL05416; AAB13623.1; JOINED; Genomic_DNA
EMBLL05417; AAB13623.1; JOINED; Genomic_DNA
EMBLL05418; AAB13623.1; JOINED; Genomic_DNA
EMBLL05419; AAB13623.1; JOINED; Genomic_DNA
EMBLL05420; AAB13623.1; JOINED; Genomic_DNA
EMBLL05421; AAB13623.1; JOINED; Genomic_DNA
EMBLL05422; AAB13623.1; JOINED; Genomic_DNA
EMBLM69215; AAB13623.1; JOINED; Genomic_DNA
EMBLL05424; AAB13624.1; -; Genomic_DNA
EMBLL05407; AAB13624.1; JOINED; Genomic_DNA
EMBLL05408; AAB13624.1; JOINED; Genomic_DNA
EMBLL05410; AAB13624.1; JOINED; Genomic_DNA
EMBLL05420; AAB13624.1; JOINED; Genomic_DNA
EMBLL05421; AAB13624.1; JOINED; Genomic_DNA
EMBLL05422; AAB13624.1; JOINED; Genomic_DNA
EMBLM69215; AAB13624.1; JOINED; Genomic_DNA
EMBLL05424; AAB13625.1; -; Genomic_DNA
EMBLL05407; AAB13625.1; JOINED; Genomic_DNA
EMBLL05408; AAB13625.1; JOINED; Genomic_DNA
EMBLL05410; AAB13625.1; JOINED; Genomic_DNA
EMBLL05411; AAB13625.1; JOINED; Genomic_DNA
EMBLL05412; AAB13625.1; JOINED; Genomic_DNA
EMBLL05414; AAB13625.1; JOINED; Genomic_DNA
EMBLL05416; AAB13625.1; JOINED; Genomic_DNA
EMBLL05417; AAB13625.1; JOINED; Genomic_DNA
EMBLL05418; AAB13625.1; JOINED; Genomic_DNA
EMBLL05419; AAB13625.1; JOINED; Genomic_DNA
EMBLL05420; AAB13625.1; JOINED; Genomic_DNA
EMBLL05421; AAB13625.1; JOINED; Genomic_DNA
EMBLL05422; AAB13625.1; JOINED; Genomic_DNA
EMBLM69215; AAB13625.1; JOINED; Genomic_DNA
EMBLL05424; AAB13626.1; -; Genomic_DNA
EMBLL05407; AAB13626.1; JOINED; Genomic_DNA
EMBLL05408; AAB13626.1; JOINED; Genomic_DNA
EMBLL05410; AAB13626.1; JOINED; Genomic_DNA
EMBLL05411; AAB13626.1; JOINED; Genomic_DNA
EMBLL05412; AAB13626.1; JOINED; Genomic_DNA
EMBLL05414; AAB13626.1; JOINED; Genomic_DNA
EMBLL05416; AAB13626.1; JOINED; Genomic_DNA
EMBLL05417; AAB13626.1; JOINED; Genomic_DNA
EMBLL05418; AAB13626.1; JOINED; Genomic_DNA
EMBLL05419; AAB13626.1; JOINED; Genomic_DNA
EMBLL05420; AAB13626.1; JOINED; Genomic_DNA
EMBLL05421; AAB13626.1; JOINED; Genomic_DNA
EMBLL05422; AAB13626.1; JOINED; Genomic_DNA
EMBLM69215; AAB13626.1; JOINED; Genomic_DNA
EMBLL05424; AAB13627.1; -; Genomic_DNA
EMBLL05407; AAB13627.1; JOINED; Genomic_DNA
EMBLL05408; AAB13627.1; JOINED; Genomic_DNA
EMBLL05410; AAB13627.1; JOINED; Genomic_DNA
EMBLL05417; AAB13627.1; JOINED; Genomic_DNA
EMBLL05418; AAB13627.1; JOINED; Genomic_DNA
EMBLL05420; AAB13627.1; JOINED; Genomic_DNA
EMBLL05421; AAB13627.1; JOINED; Genomic_DNA
EMBLL05422; AAB13627.1; JOINED; Genomic_DNA
EMBLM69215; AAB13627.1; JOINED; Genomic_DNA
EMBLL05424; AAB13628.1; -; Genomic_DNA
EMBLL05407; AAB13628.1; JOINED; Genomic_DNA
EMBLL05408; AAB13628.1; JOINED; Genomic_DNA
EMBLL05410; AAB13628.1; JOINED; Genomic_DNA
EMBLL05411; AAB13628.1; JOINED; Genomic_DNA
EMBLL05412; AAB13628.1; JOINED; Genomic_DNA
EMBLL05414; AAB13628.1; JOINED; Genomic_DNA
EMBLL05415; AAB13628.1; JOINED; Genomic_DNA
EMBLL05416; AAB13628.1; JOINED; Genomic_DNA
EMBLL05417; AAB13628.1; JOINED; Genomic_DNA
EMBLL05418; AAB13628.1; JOINED; Genomic_DNA
EMBLL05419; AAB13628.1; JOINED; Genomic_DNA
EMBLL05420; AAB13628.1; JOINED; Genomic_DNA
EMBLL05421; AAB13628.1; JOINED; Genomic_DNA
EMBLL05422; AAB13628.1; JOINED; Genomic_DNA
EMBLM69215; AAB13628.1; JOINED; Genomic_DNA
EMBLAJ251595; CAB61878.1; -; mRNA
EMBLS66400; AAB27917.1; -; mRNA
EMBLS66400; AAB27918.2; -; mRNA
EMBLS66400; AAB27919.1; -; mRNA
EMBLU40373; AAA82949.1; -; mRNA
EMBLAY101192; AAM50040.1; -; mRNA
EMBLAY101193; AAM50041.1; -; mRNA
EMBLEF581837; ABQ59315.1; -; mRNA
EMBLAL832642; CAD89965.1; -; mRNA
EMBLAL133330; CAC10347.1; -; Genomic_DNA
EMBLCH471064; EAW68147.1; -; Genomic_DNA
EMBLCH471064; EAW68148.1; -; Genomic_DNA
EMBLCH471064; EAW68149.1; -; Genomic_DNA
EMBLCH471064; EAW68151.1; -; Genomic_DNA
EMBLBC004372; AAH04372.1; -; mRNA
EMBLBC067348; AAH67348.1; -; mRNA
EMBLM25078; AAA36138.1; -; mRNA
EMBLX55938; CAA39404.1; -; mRNA
EMBLS72928; AAB30429.1; -; Genomic_DNA
EMBLX62739; CAA44602.1; -; mRNA
IPIIPI00220678; -; .
IPIIPI00297160; -; .
IPIIPI00305064; -; .
IPIIPI00418465; -; .
IPIIPI00419219; -; .
IPIIPI00827555; -; .
IPIIPI00827650; -; .
IPIIPI00827795; -; .
IPIIPI00827893; -; .
IPIIPI00827937; -; .
IPIIPI00827982; -; .
IPIIPI00828056; -; .
IPIIPI00828064; -; .
IPIIPI00828108; -; .
IPIIPI00828192; -; .
IPIIPI00956122; -; .
IPIIPI00984539; -; .
PIRA47195; A47195; .
PIRI37369; I37369; .
PIRI77371; I77371; .
PIRI77372; I77372; .
PIRJH0417; JH0417; .
PIRJH0518; JH0518; .
PIRS13530; S13530; .
PIRS24222; S24222; .
RefSeqNP_000601.3; NM_000610.3; .
RefSeqNP_001001389.1; NM_001001389.1; .
RefSeqNP_001001390.1; NM_001001390.1; .
RefSeqNP_001001391.1; NM_001001391.1; .
RefSeqNP_001001392.1; NM_001001392.1; .
RefSeqNP_001189484.1; NM_001202555.1; .
RefSeqNP_001189485.1; NM_001202556.1; .
RefSeqNP_001189486.1; NM_001202557.1; .
UniGeneHs.502328; -; .
PDB1POZ; NMR; -; A=20-178
PDB1UUH; X-ray; 2.20 A; A/B=20-178
PDB2I83; NMR; -; A=20-178
PDBsum1POZ; -; .
PDBsum1UUH; -; .
PDBsum2I83; -; .
ProteinModelPortalP16070; -; .
SMRP16070; 20-178; .
DIPDIP-1121N; -; .
IntActP16070; 10; .
STRINGP16070; -; .
PhosphoSiteP16070; -; .
SWISS-2DPAGEP16070; -; .
PRIDEP16070; -; .
EnsemblENST00000278385; ENSP00000278385; ENSG00000026508; .
GeneID960; -; .
KEGGhsa:960; -; .
UCSCuc001mwc.2; human; .
CTD960; -; .
GeneCardsGC11P034858; -; .
HGNCHGNC:1681; CD44; .
HPACAB000112; -; .
HPACAB000316; -; .
HPAHPA005785; -; .
MIM107269; gene; .
MIM172290; gene; .
MIM609027; phenotype; .
neXtProtNX_P16070; -; .
eggNOGprNOG17304; -; .
HOVERGENHBG003850; -; .
InParanoidP16070; -; .
Pathway_Interaction_DBavb3_opn_pathway; Osteopontin-mediated events; .
Pathway_Interaction_DBa4b1_paxindep_pathway; Paxillin-independent events mediated by a4b1 and a4b7; .
ReactomeREACT_6900; Immune System; .
DrugBankDB00070; Hyaluronidase; .
NextBio4000; -; .
ArrayExpressP16070; -; .
BgeeP16070; -; .
GenevestigatorP16070; -; .
GermOnlineENSG00000026508; Homo sapiens; .
GOGO:0009986; C:cell surface; IDA:BHF-UCL; .
GOGO:0005794; C:Golgi apparatus; IDA:HPA; .
GOGO:0005887; C:integral to plasma membrane; NAS:UniProtKB; .
GOGO:0005518; F:collagen binding; NAS:UniProtKB; .
GOGO:0005540; F:hyaluronic acid binding; NAS:UniProtKB; .
GOGO:0004872; F:receptor activity; IEA:UniProtKB-KW; .
GOGO:0016337; P:cell-cell adhesion; NAS:UniProtKB; .
GOGO:0007160; P:cell-matrix adhesion; NAS:UniProtKB; .
GOGO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome; .
GOGO:0043066; P:negative regulation of apoptosis; IDA:BHF-UCL; .
GOGO:0043518; P:negative regulation of DNA damage response; signal transduction by p53 class mediator; IDA:BHF-UCL
GOGO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:BHF-UCL; .
GOGO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:BHF-UCL; .
GOGO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:BHF-UCL; .
InterProIPR016186; C-type_lectin-like; .
InterProIPR016187; C-type_lectin_fold; .
InterProIPR001231; CD44_antigen; .
InterProIPR000538; Link; .
Gene3DG3DSA:; C-type_lectin-like; 1; .
PfamPF00193; Xlink; 1; .
PRINTSPR00658; CD44; .
SMARTSM00445; LINK; 1; .
SUPFAMSSF56436; C-type_lectin_fold; 1; .
PROSITEPS01241; LINK_1; 1; .
PROSITEPS50963; LINK_2; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server