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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: P22087



General information about the entry
View entry in simple text format
Entry nameFBRL_HUMAN
Primary accession numberP22087
integrated into SWISS-2DPAGE on November 9, 2001 (release 15)
2D Annotations were last modified onMay 15, 2003 (version 2)
General Annotations were last modified on May 19, 2011 (version 6)
Name and origin of the protein
DescriptionRecName: Full=rRNA 2'-O-methyltransferase fibrillarin; EC=2.1.1.-; AltName: Full=34 kDa nucleolar scleroderma antigen;.
Gene nameName=FBL
Synonyms=FIB1, FLRN
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
PubMed=12429849; [NCBI, ExPASy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEOLI_HELA_1D_HUMAN {SDS-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
  map experimental info
  protein estimated location

Mw=37156  [identification data]
Mw=36076  [identification data]

MAPPING (identification):
Tandem mass spectrometry [1];

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
UniProtKB/Swiss-ProtP22087; FBRL_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameFBRL_HUMAN
Primary accession numberP22087
Secondary accession number(s) B5BUE8 O75259 Q6IAT5 Q9UPI6
Sequence was last modified on June 20, 2001 (version 2)
Annotations were last modified on October 19, 2011 (version 121)
Name and origin of the protein
DescriptionRecName: Full=rRNA 2'-O-methyltransferase fibrillarin; EC=2.1.1.-; AltName: Full=34 kDa nucleolar scleroderma antigen;
Gene nameName=FBL
Synonyms=FIB1, FLRN
Encoded onName=FBL; Synonyms=FIB1, FLRN
Keywords3D-structure; Acetylation; Complete proteome; Methylation; Methyltransferase; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; RNA-binding; rRNA processing; Transferase.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLM59849; AAA52453.1; -; mRNA
EMBLX56597; CAA39935.1; -; mRNA
EMBLBT006830; AAP35476.1; -; mRNA
EMBLBT020144; AAV38946.1; -; mRNA
EMBLCR457069; CAG33350.1; -; mRNA
EMBLAB451384; BAG70198.1; -; mRNA
EMBLAC006950; AAD15623.1; -; Genomic_DNA
EMBLAC005393; AAC28913.1; -; Genomic_DNA
EMBLCH471126; EAW56925.1; -; Genomic_DNA
EMBLBC019260; AAH19260.1; -; mRNA
IPIIPI00025039; -; .
PIRA38712; A38712; .
RefSeqNP_001427.2; NM_001436.3; .
UniGeneHs.299002; -; .
PDB2IPX; X-ray; 1.82 A; A=83-315
PDBsum2IPX; -; .
ProteinModelPortalP22087; -; .
SMRP22087; 87-315; .
DIPDIP-27569N; -; .
IntActP22087; 12; .
MINTMINT-207612; -; .
STRINGP22087; -; .
PhosphoSiteP22087; -; .
SWISS-2DPAGEP22087; -; .
PeptideAtlasP22087; -; .
PRIDEP22087; -; .
EnsemblENST00000221801; ENSP00000221801; ENSG00000105202; .
GeneID2091; -; .
KEGGhsa:2091; -; .
UCSCuc002omn.1; human; .
CTD2091; -; .
GeneCardsGC19M036772; -; .
H-InvDBHIX0015126; -; .
HPACAB001514; -; .
MIM134795; gene; .
neXtProtNX_P22087; -; .
PharmGKBPA28012; -; .
eggNOGprNOG08878; -; .
HOGENOMHBG297404; -; .
HOVERGENHBG002472; -; .
InParanoidP22087; -; .
OrthoDBEOG4K3KX0; -; .
PhylomeDBP22087; -; .
NextBio8479; -; .
ArrayExpressP22087; -; .
BgeeP22087; -; .
CleanExHS_FBL; -; .
GenevestigatorP22087; -; .
GermOnlineENSG00000105202; Homo sapiens; .
GOGO:0031428; C:box C/D snoRNP complex; NAS:BHF-UCL; .
GOGO:0015030; C:Cajal body; IDA:BHF-UCL; .
GOGO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW; .
GOGO:0005515; F:protein binding; IPI:UniProtKB; .
GOGO:0003723; F:RNA binding; TAS:ProtInc; .
GOGO:0006364; P:rRNA processing; TAS:ProtInc; .
GOGO:0008033; P:tRNA processing; IEA:InterPro; .
InterProIPR000692; Fibrillarin; .
InterProIPR020813; Fibrillarin_CS; .
PANTHERPTHR10335; Fibrillarin; 1; .
PfamPF01269; Fibrillarin; 1; .
PIRSFPIRSF006540; Nop17p; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server