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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: P22303



General information about the entry
View entry in simple text format
Entry nameACES_HUMAN
Primary accession numberP22303
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onOctober 1, 2001 (version 1)
General Annotations were last modified on May 19, 2011 (version 11)
Name and origin of the protein
DescriptionRecName: Full=Acetylcholinesterase; Short=AChE; EC=; Flags: Precursor;.
Gene nameName=ACHE
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
MEDLINE=94147970; PubMed=8313871; [NCBI, Expasy, EBI, Israel, Japan]
Golaz O., Hughes G.J., Frutiger S., Paquet N., Bairoch A., Pasquali C., Sanchez J.-C., Tissot J.-D., Appel R.D., Walzer C., Balant L.P., Hochstrasser D.F.
''''''Plasma and red blood cell protein maps: update 1993'';'';''
Electrophoresis 14(1):1223-1231(1993)
2D PAGE maps for identified proteins
How to interpret a protein

RBC_HUMAN {Red blood cells}
Homo sapiens (Human)
Tissue: Erythrocyte
  map experimental info
  protein estimated location

pI=5.17; Mw=58933
pI=5.21; Mw=58933
pI=5.26; Mw=58465

MAPPING (identification):

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
UniProtKB/Swiss-ProtP22303; ACES_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameACES_HUMAN
Primary accession numberP22303
Secondary accession number(s) A4D2E2 B7ZKZ0 D6W5X7 Q16169 Q29S23 Q2M324 Q504V3 Q53F46 Q86TM9 Q86YX9 Q9BXP7
Sequence was last modified on August 1, 1991 (version 1)
Annotations were last modified on October 19, 2011 (version 133)
Name and origin of the protein
DescriptionRecName: Full=Acetylcholinesterase; Short=AChE; EC=; Flags: Precursor;
Gene nameName=ACHE
Encoded onName=ACHE
Keywords3D-structure; Alternative splicing; Blood group antigen; Cell junction; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; GPI-anchor; Hydrolase; Lipoprotein; Membrane; Neurotransmitter degradation; Nucleus; Polymorphism; Reference proteome; Secreted; Serine esterase; Signal; Synapse.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLM55040; AAA68151.1; -; mRNA
EMBLS71129; AAC60618.1; ALT_SEQ; Genomic_DNA
EMBLAF334270; AAO32948.1; -; mRNA
EMBLAK291321; BAF84010.1; -; mRNA
EMBLAK223443; BAD97163.1; -; mRNA
EMBLAY750146; AAU43801.1; -; Genomic_DNA
EMBLAC011895; AAP22364.1; -; Genomic_DNA
EMBLAC011895; AAP22365.1; -; Genomic_DNA
EMBLCH236956; EAL23812.1; -; Genomic_DNA
EMBLCH236956; EAL23813.1; -; Genomic_DNA
EMBLCH471091; EAW76461.1; -; Genomic_DNA
EMBLCH471091; EAW76463.1; -; Genomic_DNA
EMBLCH471091; EAW76462.1; -; Genomic_DNA
EMBLBC036813; AAH36813.1; -; mRNA
EMBLBC105060; AAI05061.1; -; mRNA
EMBLBC105062; AAI05063.1; -; mRNA
EMBLBC143469; AAI43470.1; -; mRNA
EMBLAF312032; AAK21003.1; -; Genomic_DNA
IPIIPI00220026; -; .
IPIIPI00552259; -; .
IPIIPI00844209; -; .
IPIIPI00913969; -; .
PIRA39256; A39256; .
RefSeqNP_000656.1; NM_000665.3; .
RefSeqNP_056646.1; NM_015831.2; .
UniGeneHs.154495; -; .
PDB1B41; X-ray; 2.76 A; A=36-574
PDB1F8U; X-ray; 2.90 A; A=32-614
PDB1PUV; Model; -; A=37-574
PDB1PUW; Model; -; A=37-574
PDB1VZJ; X-ray; 2.35 A; A/B/C/D/E/F/G/H=575-614
PDB2CLJ; Model; -; A=32-574
PDB2X8B; X-ray; 2.95 A; A=32-614
PDB3LII; X-ray; 3.20 A; A/B=35-574
PDBsum1B41; -; .
PDBsum1F8U; -; .
PDBsum1PUV; -; .
PDBsum1PUW; -; .
PDBsum1VZJ; -; .
PDBsum2CLJ; -; .
PDBsum2X8B; -; .
PDBsum3LII; -; .
ProteinModelPortalP22303; -; .
SMRP22303; 36-608; .
DIPDIP-1119N; -; .
IntActP22303; 6; .
MINTMINT-149019; -; .
STRINGP22303; -; .
MEROPSS09.979; -; .
PhosphoSiteP22303; -; .
SWISS-2DPAGEP22303; -; .
PRIDEP22303; -; .
EnsemblENST00000241069; ENSP00000241069; ENSG00000087085; .
EnsemblENST00000302913; ENSP00000303211; ENSG00000087085; .
EnsemblENST00000411582; ENSP00000404865; ENSG00000087085; .
EnsemblENST00000412389; ENSP00000394976; ENSG00000087085; .
EnsemblENST00000428317; ENSP00000414858; ENSG00000087085; .
GeneID43; -; .
KEGGhsa:43; -; .
UCSCuc003uxd.1; human; .
CTD43; -; .
GeneCardsGC07M095117; -; .
HPAHPA019704; -; .
MIM100740; gene+phenotype; .
MIM112100; phenotype; .
neXtProtNX_P22303; -; .
PharmGKBPA20; -; .
eggNOGprNOG15352; -; .
GeneTreeENSGT00600000084311; -; .
HOVERGENHBG008839; -; .
OrthoDBEOG46WZ86; -; .
ReactomeREACT_13685; Synaptic Transmission; .
DrugBankDB01122; Ambenonium; .
DrugBankDB00572; Atropine; .
DrugBankDB00122; Choline; .
DrugBankDB01245; Decamethonium; .
DrugBankDB00944; Demecarium bromide; .
DrugBankDB00843; Donepezil; .
DrugBankDB01010; Edrophonium; .
DrugBankDB01364; Ephedrine; .
DrugBankDB00674; Galantamine; .
DrugBankDB00483; Gallamine Triethiodide; .
DrugBankDB00677; Isoflurophate; .
DrugBankDB01400; Neostigmine; .
DrugBankDB00981; Physostigmine; .
DrugBankDB00545; Pyridostigmine; .
DrugBankDB00989; Rivastigmine; .
DrugBankDB00382; Tacrine; .
DrugBankDB01199; Tubocurarine; .
NextBio173; -; .
ArrayExpressP22303; -; .
BgeeP22303; -; .
GenevestigatorP22303; -; .
GermOnlineENSG00000087085; Homo sapiens; .
GOGO:0031225; C:anchored to membrane; IEA:UniProtKB-KW; .
GOGO:0030424; C:axon; IBA:RefGenome; .
GOGO:0005605; C:basal lamina; NAS:HGNC; .
GOGO:0030054; C:cell junction; IEA:UniProtKB-KW; .
GOGO:0009986; C:cell surface; IBA:RefGenome; .
GOGO:0030425; C:dendrite; IBA:RefGenome; .
GOGO:0005788; C:endoplasmic reticulum lumen; IBA:RefGenome; .
GOGO:0005615; C:extracellular space; IBA:RefGenome; .
GOGO:0005794; C:Golgi apparatus; IDA:HGNC; .
GOGO:0031594; C:neuromuscular junction; IBA:RefGenome; .
GOGO:0005634; C:nucleus; IEA:UniProtKB-SubCell; .
GOGO:0048471; C:perinuclear region of cytoplasm; IDA:HGNC; .
GOGO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell; .
GOGO:0045211; C:postsynaptic membrane; IBA:RefGenome; .
GOGO:0042734; C:presynaptic membrane; IBA:RefGenome; .
GOGO:0043083; C:synaptic cleft; NAS:GOC; .
GOGO:0042166; F:acetylcholine binding; NAS:UniProtKB; .
GOGO:0003990; F:acetylcholinesterase activity; IMP:UniProtKB; .
GOGO:0001540; F:beta-amyloid binding; TAS:UniProtKB; .
GOGO:0004091; F:carboxylesterase activity; IBA:RefGenome; .
GOGO:0005518; F:collagen binding; IDA:HGNC; .
GOGO:0043237; F:laminin-1 binding; IDA:HGNC; .
GOGO:0042803; F:protein homodimerization activity; NAS:UniProtKB; .
GOGO:0017171; F:serine hydrolase activity; IDA:HGNC; .
GOGO:0001507; P:acetylcholine catabolic process in synaptic cleft; NAS:UniProtKB; .
GOGO:0042982; P:amyloid precursor protein metabolic process; TAS:UniProtKB; .
GOGO:0007155; P:cell adhesion; TAS:UniProtKB; .
GOGO:0008283; P:cell proliferation; TAS:UniProtKB; .
GOGO:0019695; P:choline metabolic process; IBA:RefGenome; .
GOGO:0006260; P:DNA replication; TAS:UniProtKB; .
GOGO:0007517; P:muscle organ development; TAS:UniProtKB; .
GOGO:0032223; P:negative regulation of synaptic transmission; cholinergic; IC:HGNC
GOGO:0042136; P:neurotransmitter biosynthetic process; TAS:Reactome; .
GOGO:0002076; P:osteoblast development; IEP:HGNC; .
GOGO:0050714; P:positive regulation of protein secretion; TAS:UniProtKB; .
GOGO:0050770; P:regulation of axonogenesis; IBA:RefGenome; .
GOGO:0048814; P:regulation of dendrite morphogenesis; IBA:RefGenome; .
GOGO:0009611; P:response to wounding; TAS:UniProtKB; .
GOGO:0007416; P:synapse assembly; TAS:UniProtKB; .
InterProIPR014788; AChE_tetra; .
InterProIPR002018; CarbesteraseB; .
InterProIPR019826; Carboxylesterase_B_AS; .
InterProIPR019819; Carboxylesterase_B_CS; .
InterProIPR000997; Cholinesterase; .
PfamPF08674; AChE_tetra; 1; .
PfamPF00135; COesterase; 1; .
ProDomPD415333; AChE_tetra; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server