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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: P23528



General information about the entry
View entry in simple text format
Entry nameCOF1_HUMAN
Primary accession numberP23528
integrated into SWISS-2DPAGE on March 31, 2004 (release 17)
2D Annotations were last modified onMarch 31, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 6)
Name and origin of the protein
DescriptionRecName: Full=Cofilin-1; AltName: Full=18 kDa phosphoprotein; Short=p18; AltName: Full=Cofilin, non-muscle isoform;.
Gene nameName=CFL1
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D.
''''''New insights into HIV lymphocyte infection'';'';''
(IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004)
2D PAGE maps for identified proteins
How to interpret a protein

Homo sapiens (Human)
Tissue: Lymphocyte
  map experimental info
  protein estimated location

pI=7.95; Mw=18389  [identification data]
pI=6.63; Mw=18327  [identification data]

MAPPING (identification):
SPOT 2D-001YF4: Peptide mass fingerprinting [1];
SPOT 2D-001YF6: MALDI tandem mass spectrometry [1].

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
DOSAC-COBS 2D-PAGEP23528; P23528.
Siena-2DPAGEP23528; COF1_HUMAN.
UniProtKB/Swiss-ProtP23528; COF1_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameCOF1_HUMAN
Primary accession numberP23528
Secondary accession number(s) B3KUQ1 Q53Y87 Q9UCA2
Sequence was last modified on January 23, 2007 (version 3)
Annotations were last modified on October 19, 2011 (version 135)
Name and origin of the protein
DescriptionRecName: Full=Cofilin-1; AltName: Full=18 kDa phosphoprotein; Short=p18; AltName: Full=Cofilin, non-muscle isoform;
Gene nameName=CFL1
Encoded onName=CFL1; Synonyms=CFL
Keywords3D-structure; Acetylation; Actin-binding; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Nucleus; Phosphoprotein; Reference proteome.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLD00682; BAA00589.1; -; mRNA
EMBLU21909; AAA64501.1; -; mRNA
EMBLX95404; CAA64685.1; -; mRNA
EMBLBT006846; AAP35492.1; -; mRNA
EMBLAK097690; BAG53513.1; -; mRNA
EMBLCH471076; EAW74449.1; -; Genomic_DNA
EMBLBC011005; AAH11005.1; -; mRNA
EMBLBC012265; AAH12265.1; -; mRNA
EMBLBC012318; AAH12318.1; -; mRNA
EMBLBC018256; AAH18256.1; -; mRNA
IPIIPI00012011; -; .
PIRS12632; S12632; .
RefSeqNP_005498.1; NM_005507.2; .
UniGeneHs.170622; -; .
PDB1Q8G; NMR; -; A=1-166
PDB1Q8X; NMR; -; A=1-166
PDBsum1Q8G; -; .
PDBsum1Q8X; -; .
ProteinModelPortalP23528; -; .
SMRP23528; 1-166; .
DIPDIP-33000N; -; .
IntActP23528; 27; .
MINTMINT-4999473; -; .
STRINGP23528; -; .
PhosphoSiteP23528; -; .
SWISS-2DPAGEP23528; -; .
Aarhus/Ghent-2DPAGE4; IEF; .
OGPP23528; -; .
UCD-2DPAGEP23528; -; .
PRIDEP23528; -; .
EnsemblENST00000308162; ENSP00000309629; ENSG00000172757; .
GeneID1072; -; .
KEGGhsa:1072; -; .
UCSCuc001ofs.1; human; .
CTD1072; -; .
GeneCardsGC11M061948; -; .
H-InvDBHIX0009808; -; .
HGNCHGNC:1874; CFL1; .
HPACAB037077; -; .
MIM601442; gene; .
neXtProtNX_P23528; -; .
PharmGKBPA26423; -; .
eggNOGprNOG12143; -; .
GeneTreeENSGT00440000033289; -; .
HOGENOMHBG628477; -; .
HOVERGENHBG000381; -; .
InParanoidP23528; -; .
OrthoDBEOG4WSWBP; -; .
PhylomeDBP23528; -; .
ReactomeREACT_18266; Axon guidance; .
ReactomeREACT_604; Hemostasis; .
NextBio4476; -; .
PMAP-CutDBP23528; -; .
ArrayExpressP23528; -; .
BgeeP23528; -; .
GenevestigatorP23528; -; .
GermOnlineENSG00000172757; Homo sapiens; .
GOGO:0005737; C:cytoplasm; TAS:UniProtKB; .
GOGO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell; .
GOGO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell; .
GOGO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell; .
GOGO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell; .
GOGO:0003779; F:actin binding; IEA:UniProtKB-KW; .
GOGO:0030036; P:actin cytoskeleton organization; TAS:ProtInc; .
GOGO:0006916; P:anti-apoptosis; TAS:UniProtKB; .
GOGO:0007411; P:axon guidance; TAS:Reactome; .
GOGO:0030168; P:platelet activation; TAS:Reactome; .
GOGO:0002576; P:platelet degranulation; TAS:Reactome; .
GOGO:0009615; P:response to virus; IEP:UniProtKB; .
GOGO:0007266; P:Rho protein signal transduction; TAS:ProtInc; .
InterProIPR002108; Actin-bd_cofilin/tropomyosin; .
InterProIPR017904; ADF/Cofilin/Destrin; .
PfamPF00241; Cofilin_ADF; 1; .
SMARTSM00102; ADF; 1; .
PROSITEPS51263; ADF_H; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server